Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Hany Mohamed HASSANIN; Magdy Ahmed IBRAHIM

doi:https://doi.org/10.3906/tar-1301-112

Makale detayları

Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Yazarlar:

Hany Mohamed HASSANIN | Magdy Ahmed IBRAHIM

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.682-699

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000727547

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/tar-1301-112

Özet:

 

Chlorination, bromination, and condensation reactions of  3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic  acid (3) were studied.  Some novel 4-hydroxyquinolin-2(1H)-ones and  pyrano[3,2-c]quinolin-2(1H)-ones were also prepared.  The structures  of the novel compounds were established by elemental analyses and  spectral data.  All the products were also screened in vitro for their  antimicrobial activity.Pyranoquinolinones constitute the parent ring structure of pyranoquinoline alkaloids, which occur in the plant family Rutaceae. These pyranoquinoline alkaloids have gained considerable importance due to their pharmaceutical activities like anticoagulant, 1 coronary constricting, 2 and antifungal. 3 Pyrano[3,2-c]quinolinones were found to be active against certain immuno-reaction diseases, in particular against immediate hypersensitivity reactions (anaphylaxis). 4 .

 

Chlorination, bromination, and condensation reactions of  3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic  acid (3) were studied.  Some novel 4-hydroxyquinolin-2(1H)-ones and  pyrano[3,2-c]quinolin-2(1H)-ones were also prepared.  The structures  of the novel compounds were established by elemental analyses and  spectral data.  All the products were also screened in vitro for their  antimicrobial activity.

Makale detayları

Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Yazarlar: Hany Mohamed HASSANIN | Magdy Ahmed IBRAHIM

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.682-699

Belge Tipi: Makale

Yayın Tarihi: 4/2012

Belge Dili: İngilizce

Document ID (Org No.): 2000727547

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/tar-1301-112

Sayı

Yazarlar:

Hany Mohamed HASSANIN | Magdy Ahmed IBRAHIM

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 5, pp.682-699

Belge Tipi:

Makale

Yayın Tarihi:

4/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000727547

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/tar-1301-112