Evaluation of the Effect of Levothyroxine Treatment on Ocular Vascular System in Patients with Hypothyroidism.

Çağatay Emir Önder; Ali Mert Koçer; Mesut Özdemir; Şerife Mehlika Kuşkonmaz; Merve Temmuz Ayduğan; Sevde Nur Fırat; Pınar Kösekahya

Makale detayları

Evaluation of the Effect of Levothyroxine Treatment on Ocular Vascular System in Patients with Hypothyroidism.

Yazarlar:

Çağatay Emir Önder | Ali Mert Koçer | Mesut Özdemir | Şerife Mehlika Kuşkonmaz | Merve Temmuz Ayduğan | Sevde Nur Fırat | Pınar Kösekahya

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.111-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298042

pISSN:

2602-3148

Anahtar kelimeler:

Özet:

 Objective: Hypothyroidism, in which systemic vascular changes can be seen, is an endocrine system disease characterized by insufficient secretion of thyroid hormones. In this study, it was aimed to quantitatively investigate retinal and choroidal vascular changes in patients with primary hypothyroidism during the hypothyroid and euthyroid periods by optical coherence tomography angiography OCTA. Materials and Methods: Forty eyes of 20 patients with overt or subclinical hypothyroidism requiring treatment were included in the study. The patients were evaluated with OCTA in the euthyroid period after hypothyroid and levothyroxine treatment. Foveal avascular zone FAZ and choriocapillaris flow CF values, superficial capillary plexus SCP, deep capillary plexus DCP and radial peripapillary capillary plexus RPCP vascular density data were obtained with the OCTA device. Results: There was no statistically significant difference between hypothyroid and euthyroid periods in the vascular density values of SCP, DCP and RPCP p0,05 for all. On the other hand, statistically significant increases were observed in the euthyroid period compared to the hypothyroid period in CF measurements made using 1,2 and 3 mm scanning patterns p0,037; p0,035; p0,021 respectively. While 1 and 2 mm CF values were positively correlated with fT4 levels in the euthyroid period r0,596; p0,001 and r0,402; p0,012; a negative correlation was found between 1 mm CF measurements and patient age and TSH levels in the euthyroid period r-0,380; p0,016 and r-0,351; p0,031. Conclusion: In this study, increased CF rate was found in the euthyroid period compared to the hypothyroid period. It is thought that these changes may be related to the systemic vascular changes that can be seen in hypothyroidism, and the evaluation of ocular flow with OCTA is important in detecting possible vascular effects in patients with hypothyroidism.

 Objective: Hypothyroidism, in which systemic vascular changes can be seen, is an endocrine system disease characterized by insufficient secretion of thyroid hormones. In this study, it was aimed to quantitatively investigate retinal and choroidal vascular changes in patients with primary hypothyroidism during the hypothyroid and euthyroid periods by optical coherence tomography angiography OCTA. Materials and Methods: Forty eyes of 20 patients with overt or subclinical hypothyroidism requiring treatment were included in the study. The patients were evaluated with OCTA in the euthyroid period after hypothyroid and levothyroxine treatment. Foveal avascular zone FAZ and choriocapillaris flow CF values, superficial capillary plexus SCP, deep capillary plexus DCP and radial peripapillary capillary plexus RPCP vascular density data were obtained with the OCTA device. Results: There was no statistically significant difference between hypothyroid and euthyroid periods in the vascular density values of SCP, DCP and RPCP p0,05 for all. On the other hand, statistically significant increases were observed in the euthyroid period compared to the hypothyroid period in CF measurements made using 1,2 and 3 mm scanning patterns p0,037; p0,035; p0,021 respectively. While 1 and 2 mm CF values were positively correlated with fT4 levels in the euthyroid period r0,596; p0,001 and r0,402; p0,012; a negative correlation was found between 1 mm CF measurements and patient age and TSH levels in the euthyroid period r-0,380; p0,016 and r-0,351; p0,031. Conclusion: In this study, increased CF rate was found in the euthyroid period compared to the hypothyroid period. It is thought that these changes may be related to the systemic vascular changes that can be seen in hypothyroidism, and the evaluation of ocular flow with OCTA is important in detecting possible vascular effects in patients with hypothyroidism.

 Objective: Hypothyroidism, in which systemic vascular changes can be seen, is an endocrine system disease characterized by insufficient secretion of thyroid hormones. In this study, it was aimed to quantitatively investigate retinal and choroidal vascular changes in patients with primary hypothyroidism during the hypothyroid and euthyroid periods by optical coherence tomography angiography OCTA. Materials and Methods: Forty eyes of 20 patients with overt or subclinical hypothyroidism requiring treatment were included in the study. The patients were evaluated with OCTA in the euthyroid period after hypothyroid and levothyroxine treatment. Foveal avascular zone FAZ and choriocapillaris flow CF values, superficial capillary plexus SCP, deep capillary plexus DCP and radial peripapillary capillary plexus RPCP vascular density data were obtained with the OCTA device. Results: There was no statistically significant difference between hypothyroid and euthyroid periods in the vascular density values of SCP, DCP and RPCP p0,05 for all. On the other hand, statistically significant increases were observed in the euthyroid period compared to the hypothyroid period in CF measurements made using 1,2 and 3 mm scanning patterns p0,037; p0,035; p0,021 respectively. While 1 and 2 mm CF values were positively correlated with fT4 levels in the euthyroid period r0,596; p0,001 and r0,402; p0,012; a negative correlation was found between 1 mm CF measurements and patient age and TSH levels in the euthyroid period r-0,380; p0,016 and r-0,351; p0,031. Conclusion: In this study, increased CF rate was found in the euthyroid period compared to the hypothyroid period. It is thought that these changes may be related to the systemic vascular changes that can be seen in hypothyroidism, and the evaluation of ocular flow with OCTA is important in detecting possible vascular effects in patients with hypothyroidism.

 Amaç: Sistemik vasküler değişikliklerin görülebildiği hipotiroidizm, tiroid hormonlarının yetersiz salgılanması ile karakterize endokrin sistem hastalığıdır. Bu çalışmada primer hipotiroidisi olan hastaların hipotiroid ve ötiroid dönemlerinde retina ve koroid vasküler değişikliklerinin kantitatif olarak optik koherens tomografi anjiografi OKTA ile incelenmesi amaçlandı. Gereç ve Yöntemler: Aşikar veya tedavi gerektiren subklinik hipotiroidisi olan 20 hastanın 40 gözü çalışmaya dahil edildi. Hastalar hipotiroid ve levotiroksin tedavisi sonrası ötiroid dönemde OKTA ile değerlendirildi. OKTA cihazı ile foveal avasküler zon FAZ ve koryokapillaris akım KA değerleri ile yüzeyel kapiller pleksus YKP, derin kapiller pleksus DKPve radyal peripapiller kapiller pleksus RPKP vasküler dansite verileri elde edildi. Bulgular: YKP, DKP ve RPKP vasküler dansite değerlerinde hipotiroid ve ötiroid dönemler arasında istatistiksel olarak anlamlı fark saptanmadı tümü için p0,05. 1,2 ve 3 mm tarama paternleri kullanılarak yapılan KA ölçümlerinde ise ötiroid dönemde hipotiroid döneme göre istatistiksel anlamlı artış görüldü sırasıyla p0,037; p0,035; p0,021. 1 ve 2 mm KA değerleri ötiroid dönemdeki sT4 düzeyleri ile pozitif korelasyon gösterirken r0,596; p 0,001 ve r0,402; p0,012; 1 mm KA ölçümleri ile hasta yaşı ve ötiroid dönemdeki TSH düzeyleri arasında negatif korelasyon saptandı r-0,380; p 0,016 ve r-0,351; p0,031. Sonuç: Bu çalışmada ötiroid dönemde hipotiroid dönemle karşılaştırıldığında artmış KA hızı saptanmıştır. Bu değişikliklerin hipotroidide görülebilen sistemik vasküler değişiklikler ile ilişkili olabileceği ve hipotroidi tanılı hastalarda olası vasküler etkilerin saptanmasında OKTA ile oküler akımın değerlendirilmesinin önemli olduğu düşünülmektedir.

Makale detayları

Evaluation of the Effect of Levothyroxine Treatment on Ocular Vascular System in Patients with Hypothyroidism.

Yazarlar:

Çağatay Emir Önder | Ali Mert Koçer | Mesut Özdemir | Şerife Mehlika Kuşkonmaz | Merve Temmuz Ayduğan | Sevde Nur Fırat | Pınar Kösekahya

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.111-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298042

pISSN:

2602-3148

Hypothyroidism

Choroid plexus

Optical coherence tomography

Retinal vessels.Hipotiroidizm

Koroid pleksus

Optik koherens tomografi

Retina damarları.

Sayı

Makale detayları

Yazarlar: Çağatay Emir Önder | Ali Mert Koçer | Mesut Özdemir | Şerife Mehlika Kuşkonmaz | Merve Temmuz Ayduğan | Sevde Nur Fırat | Pınar Kösekahya

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Endokrinoloji

Dergi: Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.111-121

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001298042

pISSN: 2602-3148

Sayı

Yazarlar:

Çağatay Emir Önder | Ali Mert Koçer | Mesut Özdemir | Şerife Mehlika Kuşkonmaz | Merve Temmuz Ayduğan | Sevde Nur Fırat | Pınar Kösekahya

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.111-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001298042

pISSN:

2602-3148