Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Fatih YILMAZ; Özlem FAİZ

doi:https://doi.org/10.18596/jotcsa.390928

Makale detayları

Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Yazarlar:

Fatih YILMAZ | Özlem FAİZ

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 2, pp.551-568

Belge Tipi:

Makale

Yayın Tarihi:

12/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000503167

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.390928

Özet:

 


In this work, 15 different coumarin hydrazides were successfully synthesized
and screened for their antioxidant and antilipase activities. To do this,
firstly, salicylaldehyde derivatives and 2,2-dimethyl-1,3-dioxane-4,6-dione
(Meldrum's Acid) were reacted in ethanol in the presence  of catalytic amount of pyridine to obtain
coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds
were treated with benzotriazole in dichloromethane by using thionyl chloride to
synthesized benzotriazole derivatives (2a-e).
Then, compounds 2a-e were reacted
with three commercial hydrazides (nicotinic hydrazide, benzhydrazide and
phenylacetichydrazide) in ethanol by using microwave irradiation and
conventional heating procedures to obtain final products (3-5a-e). Finally, these compounds were tested for their anti-oxidant
and anti-pancreatic lipase activities. The structure of newly synthesized
compounds was identified by 1H NMR, 13C NMR and elemental
analysis data.


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Makale detayları

Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Yazarlar: Fatih YILMAZ | Özlem FAİZ

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya mühendisliği

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 2, pp.551-568

Belge Tipi: Makale

Yayın Tarihi: 12/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000503167

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.390928

Sayı

Yazarlar:

Fatih YILMAZ | Özlem FAİZ

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 2, pp.551-568

Belge Tipi:

Makale

Yayın Tarihi:

12/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000503167

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.390928