Prevalance of impaired glucose tolerance and its association with adverse perinatal outcomes in non-gestational diabetes pregnancies

Akın Usta; Meryem Hocaoğlu; Cagla Bulbul; Ceyda Usta

Makale detayları

Prevalance of impaired glucose tolerance and its association with adverse perinatal outcomes in non-gestational diabetes pregnancies

Yazarlar:

Akın Usta | Meryem Hocaoğlu | Cagla Bulbul | Ceyda Usta

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 50, pp.169-176

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308475

pISSN:

2980-1915

Anahtar kelimeler:

Özet:

 Objective: Gestational diabetes mellitus GDM is characterized by glucose intolerance with onset during pregnancy and is one of the most common metabolic disorders complicating pregnancy. The aim of this study was to evaluate the risk of maternal and neonatal outcomes in non-gestational diabetes pregnancies with abnormal glucose challenge test GCT and abnormal glucose tolerance test GTT results. Methods: In this retrospective cohort study of 2982 singleton pregnancies, all patients underwent a non-fasting 50 g GCT at 24 to 28 weeks of gestation. A GCT cutoff of  140 mgdl was selected. Women with an elevated GCT underwent prompt diagnostic testing with a 3-hour GTT. Subjects were divided into four groups according to GCT and GTT results. Results: There was an impaired glucose tolerance in 19.2  of patients and 14.7  of them had mild glucose intolerance and 4.5  of them had moderate glucose intolerance. As expected, there was statistically significant difference in fetal macrosomia, neonatal hypoglicemia, PE, primary CS, and preterm birth between secreening negative and GDM patients p  0.0001. We also observed statistically significant difference in neonatal hypoglicemia p  0.0001 and PE p  0.0277 between screning negative and mild glucose intolerance group. Moreover, there was a significant difference in fetal macrosomia p0.0480 between mild glucose intolerance and moderate glucose intolerance groups. Conclusion: Compared with screening negative group, mild and moderate glucose intolerance are associated with increased adverse maternal and neonatal outcomes even in the absence of GDM.

 Objective: Gestational diabetes mellitus GDM is characterized by glucose intolerance with onset during pregnancy and is one of the most common metabolic disorders complicating pregnancy. The aim of this study was to evaluate the risk of maternal and neonatal outcomes in non-gestational diabetes pregnancies with abnormal glucose challenge test GCT and abnormal glucose tolerance test GTT results. Methods: In this retrospective cohort study of 2982 singleton pregnancies, all patients underwent a non-fasting 50 g GCT at 24 to 28 weeks of gestation. A GCT cutoff of  140 mgdl was selected. Women with an elevated GCT underwent prompt diagnostic testing with a 3-hour GTT. Subjects were divided into four groups according to GCT and GTT results. Results: There was an impaired glucose tolerance in 19.2  of patients and 14.7  of them had mild glucose intolerance and 4.5  of them had moderate glucose intolerance. As expected, there was statistically significant difference in fetal macrosomia, neonatal hypoglicemia, PE, primary CS, and preterm birth between secreening negative and GDM patients p  0.0001. We also observed statistically significant difference in neonatal hypoglicemia p  0.0001 and PE p  0.0277 between screning negative and mild glucose intolerance group. Moreover, there was a significant difference in fetal macrosomia p0.0480 between mild glucose intolerance and moderate glucose intolerance groups. Conclusion: Compared with screening negative group, mild and moderate glucose intolerance are associated with increased adverse maternal and neonatal outcomes even in the absence of GDM.

 Objective: Gestational diabetes mellitus GDM is characterized by glucose intolerance with onset during pregnancy and is one of the most common metabolic disorders complicating pregnancy. The aim of this study was to evaluate the risk of maternal and neonatal outcomes in non-gestational diabetes pregnancies with abnormal glucose challenge test GCT and abnormal glucose tolerance test GTT results. Methods: In this retrospective cohort study of 2982 singleton pregnancies, all patients underwent a non-fasting 50 g GCT at 24 to 28 weeks of gestation. A GCT cutoff of  140 mgdl was selected. Women with an elevated GCT underwent prompt diagnostic testing with a 3-hour GTT. Subjects were divided into four groups according to GCT and GTT results. Results: There was an impaired glucose tolerance in 19.2  of patients and 14.7  of them had mild glucose intolerance and 4.5  of them had moderate glucose intolerance. As expected, there was statistically significant difference in fetal macrosomia, neonatal hypoglicemia, PE, primary CS, and preterm birth between secreening negative and GDM patients p  0.0001. We also observed statistically significant difference in neonatal hypoglicemia p  0.0001 and PE p  0.0277 between screning negative and mild glucose intolerance group. Moreover, there was a significant difference in fetal macrosomia p0.0480 between mild glucose intolerance and moderate glucose intolerance groups. Conclusion: Compared with screening negative group, mild and moderate glucose intolerance are associated with increased adverse maternal and neonatal outcomes even in the absence of GDM.

 Objective: Gestational diabetes mellitus GDM is characterized by glucose intolerance with onset during pregnancy and is one of the most common metabolic disorders complicating pregnancy. The aim of this study was to evaluate the risk of maternal and neonatal outcomes in non-gestational diabetes pregnancies with abnormal glucose challenge test GCT and abnormal glucose tolerance test GTT results. Methods: In this retrospective cohort study of 2982 singleton pregnancies, all patients underwent a non-fasting 50 g GCT at 24 to 28 weeks of gestation. A GCT cutoff of  140 mgdl was selected. Women with an elevated GCT underwent prompt diagnostic testing with a 3-hour GTT. Subjects were divided into four groups according to GCT and GTT results. Results: There was an impaired glucose tolerance in 19.2  of patients and 14.7  of them had mild glucose intolerance and 4.5  of them had moderate glucose intolerance. As expected, there was statistically significant difference in fetal macrosomia, neonatal hypoglicemia, PE, primary CS, and preterm birth between secreening negative and GDM patients p  0.0001. We also observed statistically significant difference in neonatal hypoglicemia p  0.0001 and PE p  0.0277 between screning negative and mild glucose intolerance group. Moreover, there was a significant difference in fetal macrosomia p0.0480 between mild glucose intolerance and moderate glucose intolerance groups. Conclusion: Compared with screening negative group, mild and moderate glucose intolerance are associated with increased adverse maternal and neonatal outcomes even in the absence of GDM.

Makale detayları

Prevalance of impaired glucose tolerance and its association with adverse perinatal outcomes in non-gestational diabetes pregnancies

Yazarlar:

Akın Usta | Meryem Hocaoğlu | Cagla Bulbul | Ceyda Usta

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 50, pp.169-176

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308475

pISSN:

2980-1915

Gestational diabetes mellitus

Fetal macrosomia

Neonatal hypoglicemia

Cesarean section

Glucose intolerance

Sayı

Makale detayları

Prevalance of impaired glucose tolerance and its association with adverse perinatal outcomes in non-gestational diabetes pregnancies

Yazarlar: Akın Usta | Meryem Hocaoğlu | Cagla Bulbul | Ceyda Usta

Yayıncı: Hatay Mustafa Kemal University

Ana Başlıklar: Obstetrics and Gynaecology

Dergi: Interdisciplinary Medical Journal Vol.14 Issue 50, pp.169-176

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001308475

pISSN: 2980-1915

Gestational diabetes mellitus

Fetal macrosomia

Neonatal hypoglicemia

Cesarean section

Glucose intolerance

Sayı

Yazarlar:

Akın Usta | Meryem Hocaoğlu | Cagla Bulbul | Ceyda Usta

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 50, pp.169-176

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001308475

pISSN:

2980-1915