Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

Hülya ÖZDEMİR; Biljana YAREN; Gökhan OTO

Makale detayları

Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

Yazarlar:

Hülya ÖZDEMİR | Biljana YAREN | Gökhan OTO

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2015 Vol.20 Issue 3, pp.131-135

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000772461

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883

Özet:

 


Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

 

Abstract

 

Purpose: In the present study the aqueous extract of Lepidium Sativum L. (family: Brassicaceae) was investigated for possible antinociceptive effect in Swiss - albino male mice.

Material and Methods: In this experiment three groups of male mice were used (n=6). Two models were used to study the effects of the extracts on nociception, acetic acid-induced writhing test and hot plate test in mice. Lepidium Sativum extract was administered in the dose of 20 mg/kg orally 30 minutes prior to pain induction.

Results: The aqueous extract showed significant (p < 0.05) analgesic activity evidenced by increase in the reaction time by hot plate method and significant (p < 0.05) reduction in acetic acid - induced writhings in mice with a maximum effect of 27.00 % reduction. These effects were compared with the control and standard drug, diclofenac sodium (50 mg/kg, p.o).

Conclusion: The results indicate that aqueous extract of Lepidium Sativum possesses a significant antinociceptive activity in central and peripheral pain models in mice and therefore, it can be used as supplemental therapy in acute or chronic pain conditions.

 

Keywords: Antinociception, aqueous extract, Lepidium Sativum L., Hot plate, Writhing test.

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Makale detayları

Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice

Yazarlar: Hülya ÖZDEMİR | Biljana YAREN | Gökhan OTO

Yayıncı: Van Yuzuncu Yıl University

Dergi: EASTERN JOURNAL OF MEDICINE 2015 Vol.20 Issue 3, pp.131-135

Belge Tipi: Makale

Yayın Tarihi: 12/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000772461

Sıklık: Aylık

eISSN: 1301-0883

pISSN: 1301-0883

Sayı

Yazarlar:

Hülya ÖZDEMİR | Biljana YAREN | Gökhan OTO

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2015 Vol.20 Issue 3, pp.131-135

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000772461

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883