The management of drug resistant seizures in tuberous sclerosis

Paolo CURATOLO; Roberta BOMBARDIERI; Mariangela PINCI; Romina MOAVERO

Makale detayları

The management of drug resistant seizures in tuberous sclerosis

Yazarlar:

Paolo CURATOLO | Roberta BOMBARDIERI | Mariangela PINCI | Romina MOAVERO

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2009 Vol.1 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

12/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000743745

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 

Tuberous Sclerosis Complex (TSC) is a multisystem autosomal dominant genetic disorder resulting from mutations in one of two genes, TSC1 and TSC2. Pathologically TSC is characterized by abnormal cellular differentiation and proliferation, as well as abnormal neuronal migration. The majority of patients with TSC have epilepsy, although the mechanisms underlying epileptogenesis remain unknown. Seizures onset is frequently during the first year of life, and in a sizable proportion of individuals tend to be refractory to antiepileptic drug treatment. This article reviews the progress in understanding drug resistant seizures in TSC, from molecular pathogenesis to the pathophysiological mechanisms of epileptogenesis, and the rationale for appropriate medical and surgical treatment.

Makale detayları

The management of drug resistant seizures in tuberous sclerosis

Yazarlar: Paolo CURATOLO | Roberta BOMBARDIERI | Mariangela PINCI | Romina MOAVERO

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2009 Vol.1 Issue 0

Belge Tipi: Makale

Yayın Tarihi: 12/2009

Belge Dili: İngilizce

Document ID (Org No.): 2000743745

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

Paolo CURATOLO | Roberta BOMBARDIERI | Mariangela PINCI | Romina MOAVERO

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2009 Vol.1 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

12/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000743745

Sıklık:

İki Yıllık

eISSN:

1309-1247