Hyponatremia: More than just an electrolyte for COVID-19 patients

Serpil Müge Değer; Emre Yasar; Hasan Selçuk Özger; Pınar Aysert Yıldız; Ulver Derici

Makale detayları

Hyponatremia: More than just an electrolyte for COVID-19 patients

Yazarlar:

Serpil Müge Değer | Emre Yasar | Hasan Selçuk Özger | Pınar Aysert Yıldız | Ulver Derici

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Üroloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.97-109

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298041

pISSN:

2602-3148

Anahtar kelimeler:

Özet:

 AIM: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to mortality. MATERIALS and METHODS: Patients were divided into two groups COVID-19 negative and positive and also another group with pneumonia and without pneumonia for covid-19 PCR positive patients. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. RESULTS: A total of 636 patients, a mean age of 50 18 years, 48  of the female with a median duration of hospitalization of 5.5 IQR, 2,11 days were included. Of those 553 87 were detected COVID-19 PCR positive and 298 47 of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients 134 IQR, 130,137 mEqL compared to negatives 139 IQR, 136, 140 mEqL p0.001. The median serum sodium levels were significantly lower in patients with pneumonia 136 IQR, 133.138 mEqL than without pneumonia 139 IQR, 137, 145 mEqL p0.001. All deaths occurred in patients with pneumonia n40 13.4 . Patients with hyponatremia had increased mortality on unadjusted OR, 3.85, 95CI: 1.73, 8.53, P0.001 and adjusted OR, 3.58, 95CI: 1.58, 8.1, P0.002 in Cox proportional hazard models CONCLUSION: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for both the diagnosis and survive of these patients.

 AIM: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to mortality. MATERIALS and METHODS: Patients were divided into two groups COVID-19 negative and positive and also another group with pneumonia and without pneumonia for covid-19 PCR positive patients. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. RESULTS: A total of 636 patients, a mean age of 50 18 years, 48  of the female with a median duration of hospitalization of 5.5 IQR, 2,11 days were included. Of those 553 87 were detected COVID-19 PCR positive and 298 47 of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients 134 IQR, 130,137 mEqL compared to negatives 139 IQR, 136, 140 mEqL p0.001. The median serum sodium levels were significantly lower in patients with pneumonia 136 IQR, 133.138 mEqL than without pneumonia 139 IQR, 137, 145 mEqL p0.001. All deaths occurred in patients with pneumonia n40 13.4 . Patients with hyponatremia had increased mortality on unadjusted OR, 3.85, 95CI: 1.73, 8.53, P0.001 and adjusted OR, 3.58, 95CI: 1.58, 8.1, P0.002 in Cox proportional hazard models CONCLUSION: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for both the diagnosis and survive of these patients.

 AIM: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to mortality. MATERIALS and METHODS: Patients were divided into two groups COVID-19 negative and positive and also another group with pneumonia and without pneumonia for covid-19 PCR positive patients. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. RESULTS: A total of 636 patients, a mean age of 50 18 years, 48  of the female with a median duration of hospitalization of 5.5 IQR, 2,11 days were included. Of those 553 87 were detected COVID-19 PCR positive and 298 47 of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients 134 IQR, 130,137 mEqL compared to negatives 139 IQR, 136, 140 mEqL p0.001. The median serum sodium levels were significantly lower in patients with pneumonia 136 IQR, 133.138 mEqL than without pneumonia 139 IQR, 137, 145 mEqL p0.001. All deaths occurred in patients with pneumonia n40 13.4 . Patients with hyponatremia had increased mortality on unadjusted OR, 3.85, 95CI: 1.73, 8.53, P0.001 and adjusted OR, 3.58, 95CI: 1.58, 8.1, P0.002 in Cox proportional hazard models CONCLUSION: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for both the diagnosis and survive of these patients.

 AMAÇ: Hiponatremi özellikle pnömonisi olan hasta grubunda sık rastlanan bir elektrolit anomalisidir. Biz bu çalışmada, COVID-19 pozitif hasta grubunda hiponatremi sıklığı ile mortalite arasındaki ilişkiyi değerlendirmeyi hedefledik. METOD: Hastalar COVID-19 PCR pozitif, negatif ve COVID-19 PCR pozitif hastalar ise kendi içinde pnömoni olan ve olmayanlar olarak gruplara ayrıldı. Hiponatremi ve mortalite arasındaki ilişki tek değişkenli ve çok değişkenli COX regresyon analizi ile incelendi. SONUÇLAR: Ortalama yaşı 50 18 yıl olan 636 hasta çalışmaya dahil edildi. Hastaların , 48i kadın ve ortanca hastanede yatış süreleri ise 5.5 IQR, 2,11 gündü. Hastaların 553 87 ünde COVID-19 PCR pozitif, ve pozitif hastaların 298inde 47 pnömoni saptandı. Ortanca serum sodyum konsantrasyonu COVID-19 PCR pozitif 134 IQR, 130,137 mEqL hastalarda, negatif 139 IQR, 136, 140 mEqL p0.001 olan hastalara göre düşük saptandı. COVID-19 PCR pozitif hasta grubu içinde pnömoni hasta grubunda 136 IQR, 133.138 mEqLserum sodyum konsantrasyonu pnömoni olmayan139 IQR, 137, 145 mEqL p0.001 gruba göre istatistiksel olarak anlamlı düzeyde düşük saptandı Tüm ölümler pnömoni ile başvuran hasta grubunda izlendi n40 13.4 . Hiponatremi hem tek değişkenli OR, 3.85, 95CI: 1.73, 8.53, P0.001 hem de çok değişkenli OR, 3.58, 95CI: 1.58, 8.1, P0.002 Cox regresyon modelinde mortalite için bağımsız bir risk faktörü olduğu görüldü. TARTIŞMA: Hastaneye başvuran COVID-19 PCR pozitif hastalarda özellikle pnömoni saptanan grupta hiponatremi sık görülmekte ve mortalite için bağımsız bir risk faktörü olarak izlenmektedir. Bu hasta grubunda prognozun belirlenmesi açısından hiponatremi önemli bir laboratuvar parametresi olarak görev yapabilir.

Makale detayları

Hyponatremia: More than just an electrolyte for COVID-19 patients

Yazarlar:

Serpil Müge Değer | Emre Yasar | Hasan Selçuk Özger | Pınar Aysert Yıldız | Ulver Derici

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Üroloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.97-109

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298041

pISSN:

2602-3148

COVID-19

hyponatremia

pneumonia

mortalityCOVID-19

Hiponatremi

pnömoni

mortalite

Sayı

Makale detayları

Yazarlar: Serpil Müge Değer | Emre Yasar | Hasan Selçuk Özger | Pınar Aysert Yıldız | Ulver Derici

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Üroloji

Dergi: Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.97-109

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001298041

pISSN: 2602-3148

Sayı

Yazarlar:

Serpil Müge Değer | Emre Yasar | Hasan Selçuk Özger | Pınar Aysert Yıldız | Ulver Derici

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Üroloji

Dergi:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.37 Issue 2, pp.97-109

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298041

pISSN:

2602-3148