Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological and biochemical parameters, and viral shedding in canine distemper

Şükrü Değirmençay

Makale detayları

Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological and biochemical parameters, and viral shedding in canine distemper

Yazarlar:

Şükrü Değirmençay

Yayıncı:

Bingol University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Türk Doğa ve Fen Dergisi Vol.12 Issue 1, pp.125-135

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286046

pISSN:

2149-6366

Anahtar kelimeler:

Özet:

 This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus CDV. Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment CT fluid treatment and antibiotic, the AR group received CT  ribavirin, the AP group received CT  proanthocyanidin, ARP group received CT  ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the AP, AR, A, and ARP groups, respectively. The AR group had fewer leucocytes, neutrophils, and monocytes P0.05. CK and CK-MB activity were significantly higher only in the A group P0.01, and decreased only in the AR group as therapy progressed. CREA values were high in AP and AR groups P0.01. The lowest Ca value was in the AR group P0.01. The least CDV presence was detected in the AR group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.

 This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus CDV. Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment CT fluid treatment and antibiotic, the AR group received CT  ribavirin, the AP group received CT  proanthocyanidin, ARP group received CT  ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the AP, AR, A, and ARP groups, respectively. The AR group had fewer leucocytes, neutrophils, and monocytes P0.05. CK and CK-MB activity were significantly higher only in the A group P0.01, and decreased only in the AR group as therapy progressed. CREA values were high in AP and AR groups P0.01. The lowest Ca value was in the AR group P0.01. The least CDV presence was detected in the AR group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.

 This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus CDV. Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment CT fluid treatment and antibiotic, the AR group received CT  ribavirin, the AP group received CT  proanthocyanidin, ARP group received CT  ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the AP, AR, A, and ARP groups, respectively. The AR group had fewer leucocytes, neutrophils, and monocytes P0.05. CK and CK-MB activity were significantly higher only in the A group P0.01, and decreased only in the AR group as therapy progressed. CREA values were high in AP and AR groups P0.01. The lowest Ca value was in the AR group P0.01. The least CDV presence was detected in the AR group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.

 Bu çalışma, canine distemper virus CDV ile doğal olarak enfekte olan köpeklerde ribavirin, proantosiyanidin ve ribavirin-proantosiyanidin kombinasyonunun etkilerini araştırdı. Her biri 2-6 aylık yaşta altı köpekten oluşan bir sağlıklı kontrol ve dört hasta grubu olmak üzere beş grup oluşturuldu. On gün boyunca A grubuna klasik tedavi KT sıvı tedavisi ve antibiyotik, AR grubuna KT  ribavirin, AP grubuna KT  proantosiyanidin, ARP grubuna KT  ribavirin-proantosiyanidin uygulandı. T0, T3, T7 ve T10 günlerinde hematolojik ve biyokimyasal analizler ve klinik skorlama yapıldı. Bu günlerde ve tedaviden sonraki beşinci ve onuncu günlerde CDV varlığına bakıldı. Klinik skorlama AP, AR, A ve ARP gruplarının sırasıyla en iyi klinik iyileşmeyi gösterdiğini ortaya koydu. AR grubunda toplam lökosit, nötrofil ve monositlerde düşüş gözlendi P0.05. CK ve CK-MB aktivitesi sadece A grubunda anlamlı olarak yüksek bulunurken P0.01, bu değerler sadece AR grubunda tedavi ilerledikçe azaldı. CREA değerleri AP ve AR gruplarında yüksekti P0.01. En düşük Ca değeri AR grubundaydı P0.01. Viral saçılım açısından en az CDV varlığı AR grubunda tespit edildi. Sonuç olarak, CDVli köpeklerde ribavirin veya proantosiyanidin kullanımı, klinik bulguların ciddiyetini azaltmaya, hayatta kalma oranını artırmaya ve viral saçılımı azaltmaya yardımcı oldu.

Makale detayları

Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological and biochemical parameters, and viral shedding in canine distemper

Yazarlar:

Şükrü Değirmençay

Yayıncı:

Bingol University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Türk Doğa ve Fen Dergisi Vol.12 Issue 1, pp.125-135

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286046

pISSN:

2149-6366

antiviral ajanlar

canine distemper virus

proantosiyanidinler

ribavirin.

antiviral ajanlar

canine distemper virus

proantosiyanidinler

ribavirin.

Sayı

Makale detayları

Yazarlar: Şükrü Değirmençay

Yayıncı: Bingol University

Ana Başlıklar: Veteriner Cerrahi

Dergi: Türk Doğa ve Fen Dergisi Vol.12 Issue 1, pp.125-135

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286046

pISSN: 2149-6366

Sayı

Yazarlar:

Şükrü Değirmençay

Yayıncı:

Bingol University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Türk Doğa ve Fen Dergisi Vol.12 Issue 1, pp.125-135

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286046

pISSN:

2149-6366