Association between aspirin resistance and indices of inflammation and platelet activity in patients with acute coronary syndrome

Fatih Aksoy; Ali Bağcı; Mehtap Savran; Halil Aşçı; Ahmet Altınbaş

Makale detayları

Association between aspirin resistance and indices of inflammation and platelet activity in patients with acute coronary syndrome

Yazarlar:

Fatih Aksoy | Ali Bağcı | Mehtap Savran | Halil Aşçı | Ahmet Altınbaş

Yayıncı:

Cukurova University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.881-890

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329049

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Aspirin resistance AR has been linked to increased cardiovascular morbidity and mortality in patients with acute coronary syndrome ACS. Both ACS and AR have also been associated with enhanced platelet activity and inflammatory responses. This study aimed to evaluate the power of the levels of uric acid UA, non-high-density lipoprotein non-HDL cholesterol, high-sensitivity C-reactive protein Hs-CRP, and gamma-glutamyltransferase GGT and the mean platelet volume MPV, to predict AR in patients with ACS. Materials and Methods: This study included543 patients with ACS. AR was identified by whole blood aggregometry. Predictors of AR were determined through multivariate regression analyses and the receiver operating characteristic ROC curve analysis. Results: The levels of UA, GGT, non-HDL cholesterol, MPV, and Hs-CRP were significantly higher in patients with AR compared to those without AR 5.61.5 vs.6.83.1, 20 vs 34 median, 162.343.2 vs. 143.237.1, 8.2 0.9 vs. 8.9 1.1, 5.0 vs 14.7 median. A multivariate regression analysis identified MPV, UA, Hs-CRP and presence of clopidogrel resistance as independent predictors of AR. Conclusion: In patients with ACS, AR was found to be associated with elevated platelet activity and inflammation, suggesting that these factors might contribute to the development of AR or might be underlying mechanisms of AR. These findings highlight potential benefit of a routine workup to assess the oxidative status, inflammation, and thrombogenicity that may help risk stratification and treatment decision-making in clinical Practice, in patients with AR.

 Purpose: Aspirin resistance AR has been linked to increased cardiovascular morbidity and mortality in patients with acute coronary syndrome ACS. Both ACS and AR have also been associated with enhanced platelet activity and inflammatory responses. This study aimed to evaluate the power of the levels of uric acid UA, non-high-density lipoprotein non-HDL cholesterol, high-sensitivity C-reactive protein Hs-CRP, and gamma-glutamyltransferase GGT and the mean platelet volume MPV, to predict AR in patients with ACS. Materials and Methods: This study included543 patients with ACS. AR was identified by whole blood aggregometry. Predictors of AR were determined through multivariate regression analyses and the receiver operating characteristic ROC curve analysis. Results: The levels of UA, GGT, non-HDL cholesterol, MPV, and Hs-CRP were significantly higher in patients with AR compared to those without AR 5.61.5 vs.6.83.1, 20 vs 34 median, 162.343.2 vs. 143.237.1, 8.2 0.9 vs. 8.9 1.1, 5.0 vs 14.7 median. A multivariate regression analysis identified MPV, UA, Hs-CRP and presence of clopidogrel resistance as independent predictors of AR. Conclusion: In patients with ACS, AR was found to be associated with elevated platelet activity and inflammation, suggesting that these factors might contribute to the development of AR or might be underlying mechanisms of AR. These findings highlight potential benefit of a routine workup to assess the oxidative status, inflammation, and thrombogenicity that may help risk stratification and treatment decision-making in clinical Practice, in patients with AR.

 Purpose: Aspirin resistance AR has been linked to increased cardiovascular morbidity and mortality in patients with acute coronary syndrome ACS. Both ACS and AR have also been associated with enhanced platelet activity and inflammatory responses. This study aimed to evaluate the power of the levels of uric acid UA, non-high-density lipoprotein non-HDL cholesterol, high-sensitivity C-reactive protein Hs-CRP, and gamma-glutamyltransferase GGT and the mean platelet volume MPV, to predict AR in patients with ACS. Materials and Methods: This study included543 patients with ACS. AR was identified by whole blood aggregometry. Predictors of AR were determined through multivariate regression analyses and the receiver operating characteristic ROC curve analysis. Results: The levels of UA, GGT, non-HDL cholesterol, MPV, and Hs-CRP were significantly higher in patients with AR compared to those without AR 5.61.5 vs.6.83.1, 20 vs 34 median, 162.343.2 vs. 143.237.1, 8.2 0.9 vs. 8.9 1.1, 5.0 vs 14.7 median. A multivariate regression analysis identified MPV, UA, Hs-CRP and presence of clopidogrel resistance as independent predictors of AR. Conclusion: In patients with ACS, AR was found to be associated with elevated platelet activity and inflammation, suggesting that these factors might contribute to the development of AR or might be underlying mechanisms of AR. These findings highlight potential benefit of a routine workup to assess the oxidative status, inflammation, and thrombogenicity that may help risk stratification and treatment decision-making in clinical Practice, in patients with AR.

 Amaç: Akut koroner sendrom AKS hastalarında aspirin direnci AD, artmış kardiyovasküler morbidite ve mortalite ile ilişkilidir. Hem AKS hem de AD, artmış trombosit aktivitesi ve inflamatuar yanıtlarla da ilişkilidir. Çalışma, AKS hastalarında ADyi tespit etmede ürik asit UA, ortalama trombosit hacmi MPV, yüksek yoğunluklu lipoprotein olmayan non-HDL kolesterol, yüksek duyarlılıklı C-reaktif protein Hs-CRP ve gama-glutamiltransferazın GGT öngörü gücünü değerlendirmeyi amaçladı. Gereç ve Yöntem: Çalışmaya 543 AKS hastası dahil edildi. AD, tam kan agregometri yöntemi ile tespit edildi. AD varlığının prediktörleri, çok değişkenli regresyon analizleri ve alıcı işletim karakteristiği ROC eğrisi analizi ile belirlendi. Bulgular: ADli hastalarda UA, GGT, non-HDL kolesterol, MPV ve Hs-CRP seviyeleri anlamlı derecede daha yüksekti 5,61,5 - 6,83,1, 20 - 34 medyan, 162,343,2 - 143,237,1, 8,2 0,9 - 8,9 1,1, 5,0 - 14,7 medyan, sırasıyla; tüm parametreler için p0,001. Çok değişkenli regresyon analizi, MPV, UA, Hs-CRP ve klopidogrel direncinin varlığının ADnin bağımsız öngörücüleri olduğunu tespit etti. Sonuç: AKS hastalarında AD, artmış trombosit aktivitesi ve inflamasyon ile ilişkilidir ve bu faktörler, ADye katkıda bulunan altta yatan mekanizmalar olabilir. Bu bulgular, AD olan hastalarda klinik uygulamada okdidatif durumun, inflamasyonun ve trombojenitenin değerlendirmesi için rutin tetkiklerin potansiyel faydasını vurgulayarak, risk sınıflandırmasına ve tedavi karar alma sürecine yardımcı olmaktadır.

Makale detayları

Association between aspirin resistance and indices of inflammation and platelet activity in patients with acute coronary syndrome

Yazarlar:

Fatih Aksoy | Ali Bağcı | Mehtap Savran | Halil Aşçı | Ahmet Altınbaş

Yayıncı:

Cukurova University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.881-890

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329049

pISSN:

2602-3032

Aspirin resistance

uric acid

gamma-glutamyltransferase

non-high density lipoprotein and High-Sensitivity C-Reactive ProteinAspirin direnci

gama-glutamiltransferaz

hCRP

Sayı

Makale detayları

Association between aspirin resistance and indices of inflammation and platelet activity in patients with acute coronary syndrome

Yazarlar: Fatih Aksoy | Ali Bağcı | Mehtap Savran | Halil Aşçı | Ahmet Altınbaş

Yayıncı: Cukurova University

Ana Başlıklar: İç Hastalıkları

Dergi: Cukurova Medical Journal Vol.49 Issue 4, pp.881-890

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001329049

pISSN: 2602-3032

Aspirin resistance

uric acid

gamma-glutamyltransferase

non-high density lipoprotein and High-Sensitivity C-Reactive ProteinAspirin direnci

gama-glutamiltransferaz

hCRP

Sayı

Yazarlar:

Fatih Aksoy | Ali Bağcı | Mehtap Savran | Halil Aşçı | Ahmet Altınbaş

Yayıncı:

Cukurova University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.881-890

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329049

pISSN:

2602-3032