Comparison of definitive chemoradiotherapy and surgical results in local advanced (stage IIIa and IIIb) non-small cell lung cancer: single-center experience

Mukaddes Yılmaz; Birsen Yücel; Derya Kirman; Orhun Akdoğan; Ozan Yazıcı

doi:https://doi.org/10.7197/223.vi.540804

Makale detayları

Comparison of definitive chemoradiotherapy and surgical results in local advanced (stage IIIa and IIIb) non-small cell lung cancer: single-center experience

Yazarlar:

Mukaddes Yılmaz | Birsen Yücel | Derya Kirman | Orhun Akdoğan | Ozan Yazıcı

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.69-74

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922604

DOI:

https://doi.org/10.7197/223.vi.540804

Anahtar kelimeler:

Özet:

 


Objective: Discussions regarding the
treatment of stage III non-small cell lung cancer (NSCLC) are still ongoing in
the literature. It is important to evaluate the developments in radiotherapy
and surgery along with the data in real life regarding stage III NSCLC. The aim
of this study is to evaluate the treatment approaches and real-life data in
stage IIIA and IIIB local advanced NSCLC.


Method: The files of 47 patients with
local advanced stage IIIA and IIIB NSCLC, who were followed up in the Gazi
University Faculty of Medicine, Medical Oncology Clinic between February 2016
and May 2018, were retrospectively evaluated.        


Results: As the primary treatment,
definitive chemoradiotherapy (CRT) to 27 (57%) patients and surgical treatment
to 20 (43%) patients were applied. It was observed that the performance status
(p=0.010) of the patients who underwent CRT was statistically significantly
worse, active smoking (p=0.033) was higher, and had a more advanced lymph node
stage (p=0.052). In the univariate analysis, it was determined that lymph node
status (p=0.011), performance status of the patients (p=0.0247), and treatment
modality of patients (p=0.001) were the prognostic factors affecting survival.
The 1-year overall survival rates and median survival of the patients were 85%
and 23 months in the surgical group respectively, and 41% and 10 months in the
definitive CRT group. In the multivariate analysis, surgery was found to be a
better independent prognostic factor than CRT (HR: 2.72, 95% CI: 1.27-5.82,
p=0.010). 









Conclusions: It was
observed that the results of the patients, who were found to be respectable as
a result of the clinical experience in stage III NSCLC patient group, were
better. The mediastinal lymph node involvement site, especially N3 lymph node
site, and the patient performance are among the important factors that
determine the prognosis in stage III NSCLC.



.

Makale detayları

Comparison of definitive chemoradiotherapy and surgical results in local advanced (stage IIIa and IIIb) non-small cell lung cancer: single-center experience

Yazarlar:

Mukaddes Yılmaz | Birsen Yücel | Derya Kirman | Orhun Akdoğan | Ozan Yazıcı

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.69-74

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922604

DOI:

https://doi.org/10.7197/223.vi.540804

Küçük hücre dışı akciğer kanseri

cerrahi

kemoradyoterapi

Sayı

Makale detayları

Comparison of definitive chemoradiotherapy and surgical results in local advanced (stage IIIa and IIIb) non-small cell lung cancer: single-center experience

Yazarlar: Mukaddes Yılmaz | Birsen Yücel | Derya Kirman | Orhun Akdoğan | Ozan Yazıcı

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.69-74

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000922604

DOI: https://doi.org/10.7197/223.vi.540804

Küçük hücre dışı akciğer kanseri

cerrahi

kemoradyoterapi

Sayı

Yazarlar:

Mukaddes Yılmaz | Birsen Yücel | Derya Kirman | Orhun Akdoğan | Ozan Yazıcı

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.69-74

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922604

DOI:

https://doi.org/10.7197/223.vi.540804