Can ABO Blood Type Determine Small Cell Lung Cancer Risk?

Bilgin Demir; Şengül Göven Barutca; Ali Aytaç; Gökhan Çolak; İbrahim Meteoğlu; Nezih Meydan; Sabri Barutca

Makale detayları

Can ABO Blood Type Determine Small Cell Lung Cancer Risk?

Yazarlar:

Bilgin Demir | Şengül Göven Barutca | Ali Aytaç | Gökhan Çolak | İbrahim Meteoğlu | Nezih Meydan | Sabri Barutca

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 3, pp.289-294

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358692

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Introduction: Many cases of small cell lung cancer SCLC are diagnosed at an advanced stage, which remains the biggest barrier to improving survival. Identifying high-risk patients for early diagnosis and treatment is crucial. ABO blood groups and Rh factor may influence the risk of SCLC. Materials and Methods: The medical records of 118 SCLC patients with confirmed ABORh blood types were retrospectively reviewed. A control group was selected from healthy blood donors of the Turkish Red Crescent. The distribution of ABORh blood groups between the patients and controls was compared. Results: The median age was 66 years range: 39-87. A clear male predominance was observed 87.3 vs. 12.7. Significant differences were found between patients and controls in terms of non-A vs. A P0.04391 and non-O vs. O P0.006289. Additionally, there was no significant difference between the patients and controls in the general distribution of ABO blood groups P0.1747. There were no statistically significant differences in terms of gender, age, or smoking status between the blood groups. Conclusion: In the study population, ABO blood groups were associated with SCLC. Having blood group A was found to reduce the risk of SCLC, whereas having blood group O increased the risk. This study is the largest to compare ABO blood groups with SCLC patient data in the literature. However, further prospective studies are required to define how ABO blood groups may influence the risk of SCLC.

 Introduction: Many cases of small cell lung cancer SCLC are diagnosed at an advanced stage, which remains the biggest barrier to improving survival. Identifying high-risk patients for early diagnosis and treatment is crucial. ABO blood groups and Rh factor may influence the risk of SCLC. Materials and Methods: The medical records of 118 SCLC patients with confirmed ABORh blood types were retrospectively reviewed. A control group was selected from healthy blood donors of the Turkish Red Crescent. The distribution of ABORh blood groups between the patients and controls was compared. Results: The median age was 66 years range: 39-87. A clear male predominance was observed 87.3 vs. 12.7. Significant differences were found between patients and controls in terms of non-A vs. A P0.04391 and non-O vs. O P0.006289. Additionally, there was no significant difference between the patients and controls in the general distribution of ABO blood groups P0.1747. There were no statistically significant differences in terms of gender, age, or smoking status between the blood groups. Conclusion: In the study population, ABO blood groups were associated with SCLC. Having blood group A was found to reduce the risk of SCLC, whereas having blood group O increased the risk. This study is the largest to compare ABO blood groups with SCLC patient data in the literature. However, further prospective studies are required to define how ABO blood groups may influence the risk of SCLC.

 Introduction: Many cases of small cell lung cancer SCLC are diagnosed at an advanced stage, which remains the biggest barrier to improving survival. Identifying high-risk patients for early diagnosis and treatment is crucial. ABO blood groups and Rh factor may influence the risk of SCLC. Materials and Methods: The medical records of 118 SCLC patients with confirmed ABORh blood types were retrospectively reviewed. A control group was selected from healthy blood donors of the Turkish Red Crescent. The distribution of ABORh blood groups between the patients and controls was compared. Results: The median age was 66 years range: 39-87. A clear male predominance was observed 87.3 vs. 12.7. Significant differences were found between patients and controls in terms of non-A vs. A P0.04391 and non-O vs. O P0.006289. Additionally, there was no significant difference between the patients and controls in the general distribution of ABO blood groups P0.1747. There were no statistically significant differences in terms of gender, age, or smoking status between the blood groups. Conclusion: In the study population, ABO blood groups were associated with SCLC. Having blood group A was found to reduce the risk of SCLC, whereas having blood group O increased the risk. This study is the largest to compare ABO blood groups with SCLC patient data in the literature. However, further prospective studies are required to define how ABO blood groups may influence the risk of SCLC.

 Giriş: Birçok küçük hücreli akciğer kanseri KHAK vakası tanı anında ileri bir aşamadadır ve bu da sağkalımın iyileştirilmesinin önündeki en büyük engeldir. Erken tanı ve tedavi şansı için yüksek risk grubundaki hastaların tanımlanması önemlidir. ABO kan grupları ve Rh faktörü KHAK riskini etkileyebilir. Gereç ve Yöntem: Serolojik olarak ABORh kan grubu doğrulanmış 118 KHAK hastasının dosyaları retrospektif olarak incelendi. Türk Kızılayının sağlıklı kan bağışçısından oluşan bir grup kontrol grubu olarak belirlendi. Bunlar arasındaki ABORh kan grubu dağılımları karşılaştırıldı. Bulgular: Ortanca yaş 66 idi aralığı: 39-87. Açık bir erkek üstünlüğü vardı 87.3e karşı 12.7. Hastalar ve kontroller arasında A olmayan ile A P0.04391 ve 0 ile 0 olmayan p0,006289 açısından anlamlı farklar vardı. Ayrıca ABO kan gruplarının genel dağılımlarında hastalar ve kontroller arasında fark yoktu p0,1747. Kan grupları arasında cinsiyet, yaş veya sigara açısından istatistiksel olarak anlamlı bir fark yoktu. Sonuçlar: Çalışma popülasyonunda, ABO kan grupları KHAK ile ilişkiliydi. A kan grubuna sahip olmak KHAK riskini azaltırken, 0 kan grubuna sahip olmak riski artırmıştır. Bildiğimiz kadarıyla literatürdeki en büyük KHAK hasta sayısının ABO kan grupları ile karşılaştıran bir çalışmadır.Ancak, ABO kan grubunun KHAK riskini nasıl etkileyebileceğini tanımlamak için daha fazla prospektif çalışmaya ihtiyaç vardır.

Makale detayları

Can ABO Blood Type Determine Small Cell Lung Cancer Risk?

Yazarlar:

Bilgin Demir | Şengül Göven Barutca | Ali Aytaç | Gökhan Çolak | İbrahim Meteoğlu | Nezih Meydan | Sabri Barutca

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 3, pp.289-294

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358692

pISSN:

2149-9063

ABO Blood-Group System

Small Cell Lung Cancer

Risk Factors

Cancer EpidemiologyABO Kan Grubu Sistemi

Küçük Hücreli Akciğer Kanseri

Risk Faktörleri

Kanser Epidemiyolojisi

Sayı

Makale detayları

Yazarlar: Bilgin Demir | Şengül Göven Barutca | Ali Aytaç | Gökhan Çolak | İbrahim Meteoğlu | Nezih Meydan | Sabri Barutca

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Clinical Oncology

Dergi: Meandros Medical And Dental Journal Vol.26 Issue 3, pp.289-294

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358692

pISSN: 2149-9063

Sayı

Yazarlar:

Bilgin Demir | Şengül Göven Barutca | Ali Aytaç | Gökhan Çolak | İbrahim Meteoğlu | Nezih Meydan | Sabri Barutca

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Oncology

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 3, pp.289-294

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358692

pISSN:

2149-9063