Development of Analytical Method for Sensitive Determination of  Streptozotocin based on Solid Phase Extraction

Ebrar KARACA; Songül ULUSOY; Ümmügülsüm MORGÜL; Halil İbrahim ULUSOY

doi:https://doi.org/10.17776/csj.791813

Makale detayları

Development of Analytical Method for Sensitive Determination of Streptozotocin based on Solid Phase Extraction

Yazarlar:

Ebrar KARACA | Songül ULUSOY | Ümmügülsüm MORGÜL | Halil İbrahim ULUSOY

Ana Başlıklar:

Kimya ve ilgili bilimler | Farmakoloji ve terapötik

Dergi:

Cumhuriyet Science Journal 2020 Vol.41 Issue 4, pp.826-831

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000920348

DOI:

https://doi.org/10.17776/csj.791813

Özet:

 

This study is focused on developing a sensitive analytical method for Streptozotocin (STZ) molecules which is a naturally occurring alkylating antineoplastic agent. It is also known particularly toxic to the insulin-producing beta cells of the pancreas in mammals. With this study, a separation-enrichment method based on solid phase extraction was developed for low levels of STZ. The synthetized material consist of a multi-walled carbon nanotube/CuO/Cu2O was used as an adsorbent in column type SPE. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. Analytical merits were obtained under the optimized conditions: linear range (100.00-1500.00 ng mL-1), limit of detection (28.57 ng mL-1), relative standard deviation (RSD) % for 250 ng mL-1 of STZ (< 4.2 %, N:3), and pre-concentration factor (125). In order to test accuracy of the method, recovery tests were applied successively by using model solutions. .

Makale detayları

Development of Analytical Method for Sensitive Determination of Streptozotocin based on Solid Phase Extraction

Yazarlar: Ebrar KARACA | Songül ULUSOY | Ümmügülsüm MORGÜL | Halil İbrahim ULUSOY

Ana Başlıklar: Kimya ve ilgili bilimler | Farmakoloji ve terapötik

Dergi: Cumhuriyet Science Journal 2020 Vol.41 Issue 4, pp.826-831

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000920348

DOI: https://doi.org/10.17776/csj.791813

Sayı

Yazarlar:

Ebrar KARACA | Songül ULUSOY | Ümmügülsüm MORGÜL | Halil İbrahim ULUSOY

Ana Başlıklar:

Kimya ve ilgili bilimler | Farmakoloji ve terapötik

Dergi:

Cumhuriyet Science Journal 2020 Vol.41 Issue 4, pp.826-831

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000920348

DOI:

https://doi.org/10.17776/csj.791813