Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Özden Öz; Abdullah İnal

Makale detayları

Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Yazarlar:

Özden Öz | Abdullah İnal

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Pathology

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 2, pp.177-183

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350733

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin  Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia PH, pyloric metaplasia PM, intestinal metaplasia IM, epithelial dysplasia ED, and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fishers exact test were used, and p 0.05 was considered significant. Results: The mean age of the patient was 53.17  13.48. PH, PM, IM, PMIM, ED, and invasive cancer were detected in 11.38, 8.92, 11.15, 07.04, 3.16, and 0.47 of all cases, respectively. The mucosal pathologies were mostly observed over 50 years p 0,05. The mass-forming lesion could not be detected among dysplasia cases p 0.0001. Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

 Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin  Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia PH, pyloric metaplasia PM, intestinal metaplasia IM, epithelial dysplasia ED, and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fishers exact test were used, and p 0.05 was considered significant. Results: The mean age of the patient was 53.17  13.48. PH, PM, IM, PMIM, ED, and invasive cancer were detected in 11.38, 8.92, 11.15, 07.04, 3.16, and 0.47 of all cases, respectively. The mucosal pathologies were mostly observed over 50 years p 0,05. The mass-forming lesion could not be detected among dysplasia cases p 0.0001. Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

 Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin  Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia PH, pyloric metaplasia PM, intestinal metaplasia IM, epithelial dysplasia ED, and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fishers exact test were used, and p 0.05 was considered significant. Results: The mean age of the patient was 53.17  13.48. PH, PM, IM, PMIM, ED, and invasive cancer were detected in 11.38, 8.92, 11.15, 07.04, 3.16, and 0.47 of all cases, respectively. The mucosal pathologies were mostly observed over 50 years p 0,05. The mass-forming lesion could not be detected among dysplasia cases p 0.0001. Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

 Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin  Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia PH, pyloric metaplasia PM, intestinal metaplasia IM, epithelial dysplasia ED, and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fishers exact test were used, and p 0.05 was considered significant. Results: The mean age of the patient was 53.17  13.48. PH, PM, IM, PMIM, ED, and invasive cancer were detected in 11.38, 8.92, 11.15, 07.04, 3.16, and 0.47 of all cases, respectively. The mucosal pathologies were mostly observed over 50 years p 0,05. The mass-forming lesion could not be detected among dysplasia cases p 0.0001. Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

Makale detayları

Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Yazarlar:

Özden Öz | Abdullah İnal

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Pathology

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 2, pp.177-183

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350733

pISSN:

1300-7416

Gallbladder

Mucosal pathologies

Cholecystectomy

Diagnosis

Demographic findings

Sayı

Makale detayları

Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Yazarlar: Özden Öz | Abdullah İnal

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Pathology

Dergi: Medical Journal of Süleyman Demirel University Vol.32 Issue 2, pp.177-183

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001350733

pISSN: 1300-7416

Gallbladder

Mucosal pathologies

Cholecystectomy

Diagnosis

Demographic findings

Sayı

Yazarlar:

Özden Öz | Abdullah İnal

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Pathology

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 2, pp.177-183

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350733

pISSN:

1300-7416