Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

N.A.

Makale detayları

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1998-2006

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346788

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The bitter taste of acetaminophen greatly reduced its formulation in oral dosage forms, so masking the taste was tested using the solid dispersion technique by Eudragit E100 and the solvent evaporation method. The obtained solid dispersions were characterized by FT-IR and DSC. Then, production yield, and drug loading have been determined, and the efficiency of this technique in taste masking by in vitro-in vivo evaluation were investigated by measuring the amount of drug released at pH6.8 similar to saliva and pH1.2 similar to stomach. FT-IR demonstrated that absence of interactions between drug and polymer and DSC results showed the complete formation of solid dispersion for F2 and partial formation with F1 and F3. Production yield was more than 96 for all formulations, and drug loading ranged between 99-103 and this increased with special dishes, while in vitro drug release results at pH1.2 after 15min reached 84.950.55,100.890.70, and 95.780.71 μgml for F1, F2, and F3 respectively. In another hand, taste-masking evaluation at pH6.8 showed drug release amount after 2min less than the determination bitterness threshold 900μgml there were 114.98,75.97, and 10.26 μgml for F1, F2, and F3 respectively. Therefore, this technique is considered efficient in masking the taste with obtaining a good production yield.

 The bitter taste of acetaminophen greatly reduced its formulation in oral dosage forms, so masking the taste was tested using the solid dispersion technique by Eudragit E100 and the solvent evaporation method. The obtained solid dispersions were characterized by FT-IR and DSC. Then, production yield, and drug loading have been determined, and the efficiency of this technique in taste masking by in vitro-in vivo evaluation were investigated by measuring the amount of drug released at pH6.8 similar to saliva and pH1.2 similar to stomach. FT-IR demonstrated that absence of interactions between drug and polymer and DSC results showed the complete formation of solid dispersion for F2 and partial formation with F1 and F3. Production yield was more than 96 for all formulations, and drug loading ranged between 99-103 and this increased with special dishes, while in vitro drug release results at pH1.2 after 15min reached 84.950.55,100.890.70, and 95.780.71 μgml for F1, F2, and F3 respectively. In another hand, taste-masking evaluation at pH6.8 showed drug release amount after 2min less than the determination bitterness threshold 900μgml there were 114.98,75.97, and 10.26 μgml for F1, F2, and F3 respectively. Therefore, this technique is considered efficient in masking the taste with obtaining a good production yield.

 The bitter taste of acetaminophen greatly reduced its formulation in oral dosage forms, so masking the taste was tested using the solid dispersion technique by Eudragit E100 and the solvent evaporation method. The obtained solid dispersions were characterized by FT-IR and DSC. Then, production yield, and drug loading have been determined, and the efficiency of this technique in taste masking by in vitro-in vivo evaluation were investigated by measuring the amount of drug released at pH6.8 similar to saliva and pH1.2 similar to stomach. FT-IR demonstrated that absence of interactions between drug and polymer and DSC results showed the complete formation of solid dispersion for F2 and partial formation with F1 and F3. Production yield was more than 96 for all formulations, and drug loading ranged between 99-103 and this increased with special dishes, while in vitro drug release results at pH1.2 after 15min reached 84.950.55,100.890.70, and 95.780.71 μgml for F1, F2, and F3 respectively. In another hand, taste-masking evaluation at pH6.8 showed drug release amount after 2min less than the determination bitterness threshold 900μgml there were 114.98,75.97, and 10.26 μgml for F1, F2, and F3 respectively. Therefore, this technique is considered efficient in masking the taste with obtaining a good production yield.

 The bitter taste of acetaminophen greatly reduced its formulation in oral dosage forms, so masking the taste was tested using the solid dispersion technique by Eudragit E100 and the solvent evaporation method. The obtained solid dispersions were characterized by FT-IR and DSC. Then, production yield, and drug loading have been determined, and the efficiency of this technique in taste masking by in vitro-in vivo evaluation were investigated by measuring the amount of drug released at pH6.8 similar to saliva and pH1.2 similar to stomach. FT-IR demonstrated that absence of interactions between drug and polymer and DSC results showed the complete formation of solid dispersion for F2 and partial formation with F1 and F3. Production yield was more than 96 for all formulations, and drug loading ranged between 99-103 and this increased with special dishes, while in vitro drug release results at pH1.2 after 15min reached 84.950.55,100.890.70, and 95.780.71 μgml for F1, F2, and F3 respectively. In another hand, taste-masking evaluation at pH6.8 showed drug release amount after 2min less than the determination bitterness threshold 900μgml there were 114.98,75.97, and 10.26 μgml for F1, F2, and F3 respectively. Therefore, this technique is considered efficient in masking the taste with obtaining a good production yield.

Makale detayları

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1998-2006

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346788

pISSN:

2630-6344

Acetaminophen

taste-masking

solid dispersion

Eudragit E100

solvent evaporation

threshold bitterness

Sayı

Makale detayları

Development a taste-masked acetaminophen solid dispersions using Eudragit® E100 polymer by solvent evaporation technique

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 5, pp.1998-2006

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346788

pISSN: 2630-6344

Acetaminophen

taste-masking

solid dispersion

Eudragit E100

solvent evaporation

threshold bitterness

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.1998-2006

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346788

pISSN:

2630-6344