The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Abdussemet HAZAR; Fuat DİLMEÇ; Mustafa GÖZ; Aydemir KOÇARSLAN; Mehmet Salih AYDIN; Abbas Heval DEMİRKOL

Makale detayları

The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Yazarlar:

Abdussemet HAZAR | Fuat DİLMEÇ | Mustafa GÖZ | Aydemir KOÇARSLAN | Mehmet Salih AYDIN | Abbas Heval DEMİRKOL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 5, pp.895-902

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754592

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specific polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. Complex diseases such as CAD, hypertension, and diabetes are usually caused by an individual’s susceptibility to various genes, environmental factors, and the interactions between them. The PON1 enzyme has been implicated in the pathogenesis of atherosclerosis and CAD.   Materials and methods: Enrolled in this study were 61 patients with CAD and 103 healthy individuals; their DNA was isolated. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the frequencies of the PON1 gene (NM000446.5, GI: 5444) c.163T>A (Hsp92IIT>A) and c.575A>G (AlwIA>G) polymorphisms in CAD cases.    Results: Our data indicated that the body mass index (BMI) (27.5 ± 5.7), low-density lipoprotein (LDL-C) values (127.0 ± 45.8), and frequencies of diabetes (13.0) and hypertension (35.0) were significantly higher in CAD patients than in the control subjects (25.9 ± 4.1; 105.6 ± 26.3; 2.0; and 19.0, respectively) (P  A and c.575A>G genotypes of the PON1 gene in CAD patients compared to healthy individuals (P > 0.05).   Conclusion: The PON1 gene c.163T>A and c.575A>G polymorphisms did not represent an important risk factor for this disease in the southeastern Turkish population.

 

To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specific polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. Complex diseases such as CAD, hypertension, and diabetes are usually caused by an individual’s susceptibility to various genes, environmental factors, and the interactions between them. The PON1 enzyme has been implicated in the pathogenesis of atherosclerosis and CAD.   Materials and methods: Enrolled in this study were 61 patients with CAD and 103 healthy individuals; their DNA was isolated. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the frequencies of the PON1 gene (NM000446.5, GI: 5444) c.163T>A (Hsp92IIT>A) and c.575A>G (AlwIA>G) polymorphisms in CAD cases.    Results: Our data indicated that the body mass index (BMI) (27.5 ± 5.7), low-density lipoprotein (LDL-C) values (127.0 ± 45.8), and frequencies of diabetes (13.0) and hypertension (35.0) were significantly higher in CAD patients than in the control subjects (25.9 ± 4.1; 105.6 ± 26.3; 2.0; and 19.0, respectively) (P  A and c.575A>G genotypes of the PON1 gene in CAD patients compared to healthy individuals (P > 0.05).   Conclusion: The PON1 gene c.163T>A and c.575A>G polymorphisms did not represent an important risk factor for this disease in the southeastern Turkish population.

Makale detayları

The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Yazarlar:

Abdussemet HAZAR | Fuat DİLMEÇ | Mustafa GÖZ | Aydemir KOÇARSLAN | Mehmet Salih AYDIN | Abbas Heval DEMİRKOL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 5, pp.895-902

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754592

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: PON1 gene

polymorphism

coronary artery disease

PCR

RFLP

Sayı

Makale detayları

The paraoxonase 1 (PON1) gene polymorphisms in coronary artery disease in the southeastern Turkish population

Yazarlar: Abdussemet HAZAR | Fuat DİLMEÇ | Mustafa GÖZ | Aydemir KOÇARSLAN | Mehmet Salih AYDIN | Abbas Heval DEMİRKOL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 5, pp.895-902

Belge Tipi: Makale

Yayın Tarihi: 4/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000754592

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: PON1 gene

polymorphism

coronary artery disease

PCR

RFLP

Sayı

Yazarlar:

Abdussemet HAZAR | Fuat DİLMEÇ | Mustafa GÖZ | Aydemir KOÇARSLAN | Mehmet Salih AYDIN | Abbas Heval DEMİRKOL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 5, pp.895-902

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754592

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144