Diagnostic Significance of Chemerin and Chitinase 3-Like Protein 1 Levels in Cholelithiasis

Alpaslan Öztürk

Makale detayları

Diagnostic Significance of Chemerin and Chitinase 3-Like Protein 1 Levels in Cholelithiasis

Yazarlar:

Alpaslan Öztürk

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Biochemistry - Proteins | Peptides and Proteomics

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.76 Issue 3, pp.173-179

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349846

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Cholelithiasis is a common gallbladder disease that refers to the formation of gallstones. In this study, we investigated the relationship between Cholelithiasis and Chitinase 3-like-1 protein Chi3L1 and Chemerin levels. Materials and Methods: Our study was conducted in 88 individuals, 44 of whom were healthy and 44 of whom had cholelithiasis. Chemerin and Chi3L1 serum levels were measured by enzyme-linked immunsorbent assay-ELISA method. The results were then analyzed using SPSS. Results: When cholelithiasis patient groups were compared with healthy groups, a significant increase was found in Chemerin levels in cholelithiasis patients 6.28-4.68, p0.001. Chi3L1 concentration values were not statistically different between groups p0.460. After receiver operating characteristic analysis, the Chemerin result was statistically significant in predicting disease p0.001, area under the curve: 0.795 0.697-0.893, Chi3L1 was statistically insignificant in predicting disease. While the difference between the patient and control groups in terms of creatinine,albumin, amylase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, direct bilirubin, sodium, and calcium was statistically significant p0.05, the difference between Chi3L1 concentration and creatinine and total protein was statistically significant p0.05. Conclusion: Our study suggests that chemerin may be a new biomarker in the diagnosis of cholelithiasis. In addition, since our study has not been done before, it can bring a new perspective to the literature. Key Words: Cholelithiasis, Chemerin, Chitinase 3-Like-1.

 Objectives: Cholelithiasis is a common gallbladder disease that refers to the formation of gallstones. In this study, we investigated the relationship between Cholelithiasis and Chitinase 3-like-1 protein Chi3L1 and Chemerin levels. Materials and Methods: Our study was conducted in 88 individuals, 44 of whom were healthy and 44 of whom had cholelithiasis. Chemerin and Chi3L1 serum levels were measured by enzyme-linked immunsorbent assay-ELISA method. The results were then analyzed using SPSS. Results: When cholelithiasis patient groups were compared with healthy groups, a significant increase was found in Chemerin levels in cholelithiasis patients 6.28-4.68, p0.001. Chi3L1 concentration values were not statistically different between groups p0.460. After receiver operating characteristic analysis, the Chemerin result was statistically significant in predicting disease p0.001, area under the curve: 0.795 0.697-0.893, Chi3L1 was statistically insignificant in predicting disease. While the difference between the patient and control groups in terms of creatinine,albumin, amylase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, direct bilirubin, sodium, and calcium was statistically significant p0.05, the difference between Chi3L1 concentration and creatinine and total protein was statistically significant p0.05. Conclusion: Our study suggests that chemerin may be a new biomarker in the diagnosis of cholelithiasis. In addition, since our study has not been done before, it can bring a new perspective to the literature. Key Words: Cholelithiasis, Chemerin, Chitinase 3-Like-1.

 Objectives: Cholelithiasis is a common gallbladder disease that refers to the formation of gallstones. In this study, we investigated the relationship between Cholelithiasis and Chitinase 3-like-1 protein Chi3L1 and Chemerin levels. Materials and Methods: Our study was conducted in 88 individuals, 44 of whom were healthy and 44 of whom had cholelithiasis. Chemerin and Chi3L1 serum levels were measured by enzyme-linked immunsorbent assay-ELISA method. The results were then analyzed using SPSS. Results: When cholelithiasis patient groups were compared with healthy groups, a significant increase was found in Chemerin levels in cholelithiasis patients 6.28-4.68, p0.001. Chi3L1 concentration values were not statistically different between groups p0.460. After receiver operating characteristic analysis, the Chemerin result was statistically significant in predicting disease p0.001, area under the curve: 0.795 0.697-0.893, Chi3L1 was statistically insignificant in predicting disease. While the difference between the patient and control groups in terms of creatinine,albumin, amylase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, direct bilirubin, sodium, and calcium was statistically significant p0.05, the difference between Chi3L1 concentration and creatinine and total protein was statistically significant p0.05. Conclusion: Our study suggests that chemerin may be a new biomarker in the diagnosis of cholelithiasis. In addition, since our study has not been done before, it can bring a new perspective to the literature. Key Words: Cholelithiasis, Chemerin, Chitinase 3-Like-1.

 Amaç: Kolelitiazis, toplumda sık görülen ve safra taşı oluşumunu ifade eden bir safra kesesi hastalığıdır. Bu çalışmada, kolelitiazis ile kitinaz 3-benzeri protein 1 Chi3L1 ve kimerin düzeyleri arasındaki ilişki araştırılmıştır. Gereç ve Yöntem: Çalışmamız 44ü sağlıklı ve 44ü kolelitiazisli olmak üzere 88 birey üzerinde yürütülmüştür. Kimerin ve Chi3L1 serum düzeyleri enzyme-linked immunsorbent assay-ELISA yöntemi ile ölçülmüştür. Sonuçlar daha sonra SPSS kullanılarak analiz edilmiştir. Bulgular: Kolelitiazis hasta grupları sağlıklı gruplarla karşılaştırıldığında, kolelitiazis hastalarında kimerin düzeylerinde anlamlı bir artış bulundu 6,28-4,68, p0,001. Chi3L1 konsantrasyon değerleri gruplar arasında istatistiksel olarak farklı değildi p0,460. Alıcı işletim karakteristiğ analizinden sonra, kimerin sonucu hastalığın öngörülmesinde istatistiksel olarak anlamlıydı p0,001, eğri altında kalan alan: 0,795 0,697-0,893, Chi3L1 hastalığın öngörülmesinde istatistiksel olarak önemsizdi. Hasta ve kontrol grupları arasında kreatinin, albümin, amilaz, alanin aminotransferaz, aspartat aminotransferaz, gama glutamiltransferaz, direkt bilirubin, sodyum ve kalsiyum açısından fark istatistiksel olarak anlamlı iken p0,05, Chi3L1 konsantrasyonu ile kreatinin ve total protein arasındaki fark istatistiksel olarak anlamlıydı p0,05. Sonuç: Çalışmamız, kimerinin kolelitiazis tanısında yeni bir biyobelirteç olabileceğini düşündürmektedir. Ayrıca çalışmamız daha önce yapılmadığı için literatüre yeni bir bakış açısı getirebilir. Anahtar Kelimeler: Kolelitiazis, Kimerin, Kitinaz Benzeri-3 Protein 1.

Makale detayları

Diagnostic Significance of Chemerin and Chitinase 3-Like Protein 1 Levels in Cholelithiasis

Yazarlar:

Alpaslan Öztürk

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Biochemistry - Proteins | Peptides and Proteomics

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.76 Issue 3, pp.173-179

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349846

pISSN:

0365-8104

Cholelithiasis

Chemerin

Chitinase 3-Like-1Kolelitiazis

Kimerin

Kitinaz Benzeri-3 Protein 1

Sayı

Makale detayları

Diagnostic Significance of Chemerin and Chitinase 3-Like Protein 1 Levels in Cholelithiasis

Yazarlar: Alpaslan Öztürk

Yayıncı: Ankara University

Ana Başlıklar: Medical Biochemistry - Proteins | Peptides and Proteomics

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.76 Issue 3, pp.173-179

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001349846

pISSN: 0365-8104

Cholelithiasis

Chemerin

Chitinase 3-Like-1Kolelitiazis

Kimerin

Kitinaz Benzeri-3 Protein 1

Sayı

Yazarlar:

Alpaslan Öztürk

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Biochemistry - Proteins | Peptides and Proteomics

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.76 Issue 3, pp.173-179

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001349846

pISSN:

0365-8104