A Contemporary Series on Retropubic Radical Prostatectomy and an Analysis of Factors Influencing Biochemical Recurrence-Free Survival

Yavuz Mert Aydın; Necmettin Aydın Mungan

Makale detayları

A Contemporary Series on Retropubic Radical Prostatectomy and an Analysis of Factors Influencing Biochemical Recurrence-Free Survival

Yazarlar:

Yavuz Mert Aydın | Necmettin Aydın Mungan

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Üroloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.51 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348991

pISSN:

1300-414X

Anahtar kelimeler:

Özet:

 This study investigates outcomes and identifies factors influencing biochemical recurrence and biochemical recurrence-free survival BRFS rates in patients undergoing retropubic radical prostatectomy RRP at a tertiary university hospital over 10 years. Data of patients who underwent RRP between 2012 and 2022 were analyzed retrospectively. Variables included demographic information, preoperative prostate-specific antigen PSA levels, prostate volume, PSA density, operative details, histopathological findings, and postoperative follow-up data. Patients without at least three years of regular follow-up were excluded from the study. The Cox regression analyses were performed to determine the independent risk factors for BRFS. Survival analysis was performed using Kaplan-Meier and the logrank test. The final analysis included 115 patients. The median follow-up duration was 77.2 months range: 36.3153.6, and the median BRFS was 47.3 months range: 0153.6. The 3-year BRFS rate was 61.8. Positive surgical margins were identified as a significant predictor of BRFS HR: 2.388, p0.004, while higher PSA density and the ISUP grade groups also showed associations with recurrence risk p 0.033 and 0.048, respectively. Survival analyses confirmed shorter BRFS in patients with positive surgical margins p0.000. This study highlights the effectiveness of RRP in the surgical management of localized PCA. Surgical margin status emerged as the primary predictor of BRFS. PSA density may be a promising parameter in predicting biochemical recurrence, but further studies are needed.

 This study investigates outcomes and identifies factors influencing biochemical recurrence and biochemical recurrence-free survival BRFS rates in patients undergoing retropubic radical prostatectomy RRP at a tertiary university hospital over 10 years. Data of patients who underwent RRP between 2012 and 2022 were analyzed retrospectively. Variables included demographic information, preoperative prostate-specific antigen PSA levels, prostate volume, PSA density, operative details, histopathological findings, and postoperative follow-up data. Patients without at least three years of regular follow-up were excluded from the study. The Cox regression analyses were performed to determine the independent risk factors for BRFS. Survival analysis was performed using Kaplan-Meier and the logrank test. The final analysis included 115 patients. The median follow-up duration was 77.2 months range: 36.3153.6, and the median BRFS was 47.3 months range: 0153.6. The 3-year BRFS rate was 61.8. Positive surgical margins were identified as a significant predictor of BRFS HR: 2.388, p0.004, while higher PSA density and the ISUP grade groups also showed associations with recurrence risk p 0.033 and 0.048, respectively. Survival analyses confirmed shorter BRFS in patients with positive surgical margins p0.000. This study highlights the effectiveness of RRP in the surgical management of localized PCA. Surgical margin status emerged as the primary predictor of BRFS. PSA density may be a promising parameter in predicting biochemical recurrence, but further studies are needed.

 This study investigates outcomes and identifies factors influencing biochemical recurrence and biochemical recurrence-free survival BRFS rates in patients undergoing retropubic radical prostatectomy RRP at a tertiary university hospital over 10 years. Data of patients who underwent RRP between 2012 and 2022 were analyzed retrospectively. Variables included demographic information, preoperative prostate-specific antigen PSA levels, prostate volume, PSA density, operative details, histopathological findings, and postoperative follow-up data. Patients without at least three years of regular follow-up were excluded from the study. The Cox regression analyses were performed to determine the independent risk factors for BRFS. Survival analysis was performed using Kaplan-Meier and the logrank test. The final analysis included 115 patients. The median follow-up duration was 77.2 months range: 36.3153.6, and the median BRFS was 47.3 months range: 0153.6. The 3-year BRFS rate was 61.8. Positive surgical margins were identified as a significant predictor of BRFS HR: 2.388, p0.004, while higher PSA density and the ISUP grade groups also showed associations with recurrence risk p 0.033 and 0.048, respectively. Survival analyses confirmed shorter BRFS in patients with positive surgical margins p0.000. This study highlights the effectiveness of RRP in the surgical management of localized PCA. Surgical margin status emerged as the primary predictor of BRFS. PSA density may be a promising parameter in predicting biochemical recurrence, but further studies are needed.

 Bu çalışmanın amacı uçuncu basamak sağlık hizmeti veren bir universite hastanesinde son 10 yılda yapılan retropubik radikal prostatektomi RRP ameliyatlarının sonuçlarını değerlendirmek ve cerrahi tedavi alan hastalarda biyokimyasal nuksuz sağkalımı BNS etkileyen faktörleri belirlemektir. Bu çalışma için kliniğimizde 2012-2022 yılları arasında RRP geçiren hastaların verilerini retrospektif olarak analiz edildi. İncelenen veriler arasında; hastaların demografik bilgileri, preoperatif prostat spesifik antijen PSA duzeyi, prostat hacmi, PSA dansitesi, operatif veriler, histopatolojik sonuçlar ve postoperatif takip bilgileri mevcuttu. En az uç yıllık duzenli takibi olmayan hastalar çalışma dışı bırakıldı. BNS uzerine etki eden faktörleri belirlemek için Cox regresyon analizi uygulandı. Sağkalım analizi log-rank testi uygulanarak Kaplan-Meier grafi ile verildi. Analize 115 hasta dahil edildi. Medyan takip suresi 77,2 ay 36,3153,6 ve medyan BNS 47,3 aydı 0153,6. 3 yıllık BNS oranı 61.8 olarak bulundu. Cerrahi sınır pozitifliği BNS etkileyen önemli bir faktör olarak tespit edildi HR: 2.388, p0.004. Ayrıca yuksek PSA dansitesi ve yuksek ISUP derece grup varlığı biyokimyasal rekurrens ile ilişkili bulunmuştur p sırasıyla  0,033 ve 0,048. Sağkalım analizi cerrahi sınırı pozitif olan hastaların daha kısa BNS suresine sahip olduklarını göstermiştir. p0.000. Bu çalışa RRP nin lokalize prostat kanseri tedavisindeki yerini vurgulamıştır. Cerrahi sınır durumu BNS yi öngörmede anlamlı bir parametredir. PSA dansitesi biyokimyasal rekurrensi öngörmede umut vaat eden bir parametredir; ancak bu konuda daha ileri çalışmalara gereksinim vardır.

Makale detayları

A Contemporary Series on Retropubic Radical Prostatectomy and an Analysis of Factors Influencing Biochemical Recurrence-Free Survival

Yazarlar:

Yavuz Mert Aydın | Necmettin Aydın Mungan

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Üroloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.51 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348991

pISSN:

1300-414X

Retropubic radical prostatectomy

prostate cancer

biochemical recurrence-free survivalRetropubik radikal prostatektomi

prostat kanseri

biyokimyasal rekürrenssiz sağkalım

Sayı

Makale detayları

A Contemporary Series on Retropubic Radical Prostatectomy and an Analysis of Factors Influencing Biochemical Recurrence-Free Survival

Yazarlar: Yavuz Mert Aydın | Necmettin Aydın Mungan

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Üroloji

Dergi: Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.51 Issue 1, pp.15-21

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348991

pISSN: 1300-414X

Retropubic radical prostatectomy

prostate cancer

biochemical recurrence-free survivalRetropubik radikal prostatektomi

prostat kanseri

biyokimyasal rekürrenssiz sağkalım

Sayı

Yazarlar:

Yavuz Mert Aydın | Necmettin Aydın Mungan

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Üroloji

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.51 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348991

pISSN:

1300-414X