The effect of cardiometabolic control and malnutrition on the prevalence and prognosis of diabetic retinopathy in type 2 diabetes

Melek Özdemir; Yaşar Dağ; Mehmet Uzunlulu; Aytekin Oğuz; Aylin Ardagil; Ömer Acar; Bensu Selbest

Makale detayları

The effect of cardiometabolic control and malnutrition on the prevalence and prognosis of diabetic retinopathy in type 2 diabetes

Yazarlar:

Melek Özdemir | Yaşar Dağ | Mehmet Uzunlulu | Aytekin Oğuz | Aylin Ardagil | Ömer Acar | Bensu Selbest

Yayıncı:

Pamukkale University

Ana Başlıklar:

Endokrinoloji

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.420-429

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314152

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: This study aims to investigate the predictive value of cardiometabolic control, gamma glutamyl transferase GGT and malnutrition-related inflammation markers for predicting diabetic retinopathy DR prevalence and prognosis. Materials and methods: Type 2 Diabetes Mellitus patients who were consecutively admitted to Internal and Ophthalmology outpatient clinics were included in this study. Clinical, haematological and biochemical data were recorded. Cut-off values of GGT, hemoglobin, albumin, lymphocyte and platelet HALP score, nutritional risk index NRI and prognostic nutritional index PNI scores were determined by receiver operator characteristic curve analysis. Univariate and multivariate analyses were performed to determine the association of all variables with DR. We evaluated which of these tests were predictive and prognostic for the development of DR. Results: This study included 166 patients. Fasting blood glucose p0.001, creatinine p0.01, HbA1c p0.001 and microalbuminuria p0.01 were higher in patients with retinopathy. Mean arterial pressure p0.01, fasting blood glucose p0.03, triglyceride p0.008, body mass index BMI p0.02 and HbA1c p0.04 increased significantly as GGT level increased. Contrary to the literature, HALP, PNI and NRI scores were not associated with DR. Conclusion: Duration of diabetes, cardiometabolic control and GGT level are variables with predictive value for the prognosis of DR. No significant.

 Purpose: This study aims to investigate the predictive value of cardiometabolic control, gamma glutamyl transferase GGT and malnutrition-related inflammation markers for predicting diabetic retinopathy DR prevalence and prognosis. Materials and methods: Type 2 Diabetes Mellitus patients who were consecutively admitted to Internal and Ophthalmology outpatient clinics were included in this study. Clinical, haematological and biochemical data were recorded. Cut-off values of GGT, hemoglobin, albumin, lymphocyte and platelet HALP score, nutritional risk index NRI and prognostic nutritional index PNI scores were determined by receiver operator characteristic curve analysis. Univariate and multivariate analyses were performed to determine the association of all variables with DR. We evaluated which of these tests were predictive and prognostic for the development of DR. Results: This study included 166 patients. Fasting blood glucose p0.001, creatinine p0.01, HbA1c p0.001 and microalbuminuria p0.01 were higher in patients with retinopathy. Mean arterial pressure p0.01, fasting blood glucose p0.03, triglyceride p0.008, body mass index BMI p0.02 and HbA1c p0.04 increased significantly as GGT level increased. Contrary to the literature, HALP, PNI and NRI scores were not associated with DR. Conclusion: Duration of diabetes, cardiometabolic control and GGT level are variables with predictive value for the prognosis of DR. No significant.

 Purpose: This study aims to investigate the predictive value of cardiometabolic control, gamma glutamyl transferase GGT and malnutrition-related inflammation markers for predicting diabetic retinopathy DR prevalence and prognosis. Materials and methods: Type 2 Diabetes Mellitus patients who were consecutively admitted to Internal and Ophthalmology outpatient clinics were included in this study. Clinical, haematological and biochemical data were recorded. Cut-off values of GGT, hemoglobin, albumin, lymphocyte and platelet HALP score, nutritional risk index NRI and prognostic nutritional index PNI scores were determined by receiver operator characteristic curve analysis. Univariate and multivariate analyses were performed to determine the association of all variables with DR. We evaluated which of these tests were predictive and prognostic for the development of DR. Results: This study included 166 patients. Fasting blood glucose p0.001, creatinine p0.01, HbA1c p0.001 and microalbuminuria p0.01 were higher in patients with retinopathy. Mean arterial pressure p0.01, fasting blood glucose p0.03, triglyceride p0.008, body mass index BMI p0.02 and HbA1c p0.04 increased significantly as GGT level increased. Contrary to the literature, HALP, PNI and NRI scores were not associated with DR. Conclusion: Duration of diabetes, cardiometabolic control and GGT level are variables with predictive value for the prognosis of DR. No significant.

 Amaç: Bu çalışmanın amacı kardiyometabolik kontrol, gama glutamil transferaz GGT ve malnütrisyonla ilişkili inflamasyon belirteçlerinin diyabetik retinopati DR prevalansı ve prognozunu öngörmedeki değerini araştırmaktır. Gereç ve yöntem: Bu çalışmaya Dahiliye ve Göz Hastalıkları polikliniklerine ardışık olarak başvuran Tip 2 Diabetes Mellitus hastaları dahil edilmiştir. Klinik, hematolojik ve biyokimyasal veriler kaydedildi. Alıcı operatör karakteristik eğri analizi ile GGT, hemoglobin, albümin, lenfosit ve trombosit HALP skoru, nutrisyonel risk indeksi NRI ve prognostik nutrisyonel indeks PNI skorlarının cut-off değerleri belirlendi. Tüm değişkenlerin DR ile ilişkisini belirlemek için tek değişkenli ve çok değişkenli analizler yapıldı. Bu testlerden hangilerinin DR gelişimi için öngörücü ve prognostik olduğu değerlendirilmiştir. Bulgular: Bu çalışmaya 166 Tip 2 Diyabetes Mellitus hastası dahil edildi. Retinopati olanlarda; açlık kan glukozu p0,001, kreatinin p0,01, HbA1c p0,001 ve mikroalbüminüri p0,01 yüksek bulundu. Hastaların GGT düzeyi arttıkça ortalama arteriyel basınç p0,01, açlık kan glukoz p0,03, trigliserit p0,008, vücut kütle indeksi BMI p0,02 ve HbA1c p0,04 değerlerinin anlamlı arttığı bulundu. Literatürün aksine HALP, PNI ve NRI skorun DR ile anlamlı ilişki saptanmadı. Sonuç: Diyabet süresi, kardiyometabolik kontrol ve GGT düzeyi diyabetik retinopati prognozu için prediktif değeri olan değişkenlerdir. Malnütrisyonla ilişkili inflamasyon belirteçleri ile DR gelişimi ve evresi arasında anlamlı bir ilişki bulunmamıştır.

Makale detayları

The effect of cardiometabolic control and malnutrition on the prevalence and prognosis of diabetic retinopathy in type 2 diabetes

Yazarlar:

Melek Özdemir | Yaşar Dağ | Mehmet Uzunlulu | Aytekin Oğuz | Aylin Ardagil | Ömer Acar | Bensu Selbest

Yayıncı:

Pamukkale University

Ana Başlıklar:

Endokrinoloji

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.420-429

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314152

pISSN:

1308-0865

Diabetic retinopathy

cardiometabolic control

GGT

malnutrition releated inflamation markersDiyabetik retinopati

kardiyometabolik kontrol

GGT

malnutrisyon ilişkili inflamasyon belirteçleri

Sayı

Makale detayları

Yazarlar: Melek Özdemir | Yaşar Dağ | Mehmet Uzunlulu | Aytekin Oğuz | Aylin Ardagil | Ömer Acar | Bensu Selbest

Yayıncı: Pamukkale University

Ana Başlıklar: Endokrinoloji

Dergi: Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.420-429

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314152

pISSN: 1308-0865

Sayı

Yazarlar:

Melek Özdemir | Yaşar Dağ | Mehmet Uzunlulu | Aytekin Oğuz | Aylin Ardagil | Ömer Acar | Bensu Selbest

Yayıncı:

Pamukkale University

Ana Başlıklar:

Endokrinoloji

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.420-429

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314152

pISSN:

1308-0865