The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients

Berit Gökçe CEYLAN; Lütfi YAVUZ; Füsun EROĞLU; Şenol GÜLMEN; Ömer Rıdvan TARHAN; Adnan ALACA

Makale detayları

The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients

Yazarlar:

Berit Gökçe CEYLAN | Lütfi YAVUZ | Füsun EROĞLU | Şenol GÜLMEN | Ömer Rıdvan TARHAN | Adnan ALACA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 6, pp.949-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754912

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

As liver and kidney failure have a direct effect on mortality, morbidity, and intensive care unit (ICU) length of stay in sepsis patients, maintaining their functions or minimizing the degree of failure should be one of the most important goals of therapy. In this retrospective study we investigated the effects of recently introduced adjuvant therapies on hepatorenal functions in septic ICU patients.   Materials and methods: We conducted comparative and retrospective data analysis of 108 patients with sepsis that were followed-up during a 2-year period in the ICU. We recorded AST, ALT, ALP, albumin, bilirubin, and INR in order to evaluate variations in hepatic functions, and we recorded creatinine, BUN, and mean hourly urinary output in order to evaluate variations in renal functions in patients that received standard antibiotherapy only (ST group), in those that received polyvalent IgM-enriched immunoglobulin therapy added to standard antibiotherapy (IVIg group), and in those that received recombinant human-activated protein C therapy added to standard antibiotherapy (APC group). Variables at the beginning of the treatments and 96 h post-treatment were assessed.   Results: In total, 108 patients were analyzed (IVIg group: n = 20 in; APC: group n = 22; ST group: n = 66). The groups were homogeneous in terms of initial hepatic and renal functions, according to AST, ALT, albumin, INR, bilirubin, BUN, creatinine, and mean hourly urinary output. In the APC group the AST level at 96 h was significantly lower than that at baseline (0 h), and in the ST group 96-h bilirubin was lower than that at baseline (0 h) (P = 0.035 and P = 0.015, respectively).   Conclusion: We retrospectively observed that the adjuvant therapies did not improve hepatorenal functions in our ICU septic patients.

 

As liver and kidney failure have a direct effect on mortality, morbidity, and intensive care unit (ICU) length of stay in sepsis patients, maintaining their functions or minimizing the degree of failure should be one of the most important goals of therapy. In this retrospective study we investigated the effects of recently introduced adjuvant therapies on hepatorenal functions in septic ICU patients.   Materials and methods: We conducted comparative and retrospective data analysis of 108 patients with sepsis that were followed-up during a 2-year period in the ICU. We recorded AST, ALT, ALP, albumin, bilirubin, and INR in order to evaluate variations in hepatic functions, and we recorded creatinine, BUN, and mean hourly urinary output in order to evaluate variations in renal functions in patients that received standard antibiotherapy only (ST group), in those that received polyvalent IgM-enriched immunoglobulin therapy added to standard antibiotherapy (IVIg group), and in those that received recombinant human-activated protein C therapy added to standard antibiotherapy (APC group). Variables at the beginning of the treatments and 96 h post-treatment were assessed.   Results: In total, 108 patients were analyzed (IVIg group: n = 20 in; APC: group n = 22; ST group: n = 66). The groups were homogeneous in terms of initial hepatic and renal functions, according to AST, ALT, albumin, INR, bilirubin, BUN, creatinine, and mean hourly urinary output. In the APC group the AST level at 96 h was significantly lower than that at baseline (0 h), and in the ST group 96-h bilirubin was lower than that at baseline (0 h) (P = 0.035 and P = 0.015, respectively).   Conclusion: We retrospectively observed that the adjuvant therapies did not improve hepatorenal functions in our ICU septic patients.

Makale detayları

The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients

Yazarlar:

Berit Gökçe CEYLAN | Lütfi YAVUZ | Füsun EROĞLU | Şenol GÜLMEN | Ömer Rıdvan TARHAN | Adnan ALACA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 6, pp.949-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754912

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Sepsis

hepatic functions

renal functions

activated protein C

intravenous immunoglobulin

Sayı

Makale detayları

The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients

Yazarlar: Berit Gökçe CEYLAN | Lütfi YAVUZ | Füsun EROĞLU | Şenol GÜLMEN | Ömer Rıdvan TARHAN | Adnan ALACA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 6, pp.949-957

Belge Tipi: Makale

Yayın Tarihi: 5/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754912

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Sepsis

hepatic functions

renal functions

activated protein C

intravenous immunoglobulin

Sayı

Yazarlar:

Berit Gökçe CEYLAN | Lütfi YAVUZ | Füsun EROĞLU | Şenol GÜLMEN | Ömer Rıdvan TARHAN | Adnan ALACA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 6, pp.949-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754912

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144