Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Fazel NASUHI PUR; Karim AKBARI DILMAGHANI

doi:https://doi.org/10.3906/kim-1307-32

Makale detayları

Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Yazarlar:

Fazel NASUHI PUR | Karim AKBARI DILMAGHANI

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.288-296

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727220

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1307-32

Özet:

 

Four 6-aminopenicillanic acid moieties were grafted at either rim of  calix[4]arene, giving 2 novel generations of penicillin, which were named  calixpenam. Antibiotic tests showed that they have amplified activity with  respect to the corresponding penams against 3 gram-positive  nonpenicillinase-producing strains of Streptococcus.

 

Four 6-aminopenicillanic acid moieties were grafted at either rim of  calix[4]arene, giving 2 novel generations of penicillin, which were named  calixpenam. Antibiotic tests showed that they have amplified activity with  respect to the corresponding penams against 3 gram-positive  nonpenicillinase-producing strains of Streptococcus.

Makale detayları

Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Yazarlar: Fazel NASUHI PUR | Karim AKBARI DILMAGHANI

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.288-296

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000727220

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1307-32

Sayı

Yazarlar:

Fazel NASUHI PUR | Karim AKBARI DILMAGHANI

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.288-296

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727220

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1307-32