Serum Melatonin Levels Related with Night Pain and High Disease Activity in Seronegative Spondyloarthritis Patients

Cengiz KARACAER; Cemal BES; Erdinc SERİN; Mehmet SOY

Makale detayları

Serum Melatonin Levels Related with Night Pain and High Disease Activity in Seronegative Spondyloarthritis Patients

Yazarlar:

Cengiz KARACAER | Cemal BES | Erdinc SERİN | Mehmet SOY

Yayıncı:

Ramazan AKDEMİR

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Human Rhythm 2020 Vol.6 Issue 4, pp.177-187

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000739641

Sıklık:

Üç Aylık

eISSN:

2149-455X

Özet:

 

Aim: Circadian rhythms play a major role in regulation of human physiological functions. Many signs and symptoms of inflammatory arthritis, especially in rheumatoid arthritis (RA), show intra- and  inter-day variations. We aimed to measure serum levels of melatonin (MLT), interferon gamma (IFNγ), interleukin-10 (IL-10) and cortisol and to investigate relation with clinical parameters in patients with seronegative spondyloarthritis (SPA).
Methods: The study was designed prospectively. 17 patients with SPA (9 patients with Anklyosing Sponylitis, 8 patients with psoriatic arthritis), 20 patients with RA and 20 healthy controls were included to study.  Serum MLT, IFNγ, IL-10 and cortisol measurement were made in patients and healthy controls at 8 p.m., 3 a.m. and 8 a.m. 
Results: We found that MLT values of SPA patients were statistically lower (p=0,017) than healthy groups at 3 a.m.. Level of cortisol in RA patients at 8 a.m. were significantly lower than SPA patient and healthy control groups (p=0.047 and p=0.006; respectively). Cortisol levels in SPA patients which is measured at 8 a.m. was significantly higher (p=0.001) than  other measurement in day. There was also significant positive correlation between Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and MLT levels measured at 8:00 p.m. in patients with SPA (r=0.688; p=0.040). 
Conclusion: Serum MLT levels well correlated with disease activity in SPA patients.   Back pain which is seen midnight can be related to decrease in MLT secretion. Our findings suggests MLT have a role in pathogenesis of SPA but, it is need more detailed studies for explaining of this role of MLT  in pathogenesis of SPA.

Makale detayları

Serum Melatonin Levels Related with Night Pain and High Disease Activity in Seronegative Spondyloarthritis Patients

Yazarlar: Cengiz KARACAER | Cemal BES | Erdinc SERİN | Mehmet SOY

Yayıncı: Ramazan AKDEMİR

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Human Rhythm 2020 Vol.6 Issue 4, pp.177-187

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000739641

Sıklık: Üç Aylık

eISSN: 2149-455X

Sayı

Yazarlar:

Cengiz KARACAER | Cemal BES | Erdinc SERİN | Mehmet SOY

Yayıncı:

Ramazan AKDEMİR

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Human Rhythm 2020 Vol.6 Issue 4, pp.177-187

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000739641

Sıklık:

Üç Aylık

eISSN:

2149-455X