Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats

İsmail Bayram Güllü; Sevil Albayrak; Emin Kaymak; Arzu Yay

Makale detayları

Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats

Yazarlar:

İsmail Bayram Güllü | Sevil Albayrak | Emin Kaymak | Arzu Yay

Yayıncı:

Hacettepe University

Ana Başlıklar:

Engineering

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 3, pp.259-270

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293123

pISSN:

2687-475X

Anahtar kelimeler:

Özet:

 In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

 In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

 In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

 In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

Makale detayları

Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats

Yazarlar:

İsmail Bayram Güllü | Sevil Albayrak | Emin Kaymak | Arzu Yay

Yayıncı:

Hacettepe University

Ana Başlıklar:

Engineering

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 3, pp.259-270

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293123

pISSN:

2687-475X

Antidiabetic activity

Antioxidant activity

Carvacrol

Origanum minutiflorum.Antidiabetic activity

Antioxidant activity

Carvacrol

Origanum minutiflorum.

Sayı

Makale detayları

Yazarlar: İsmail Bayram Güllü | Sevil Albayrak | Emin Kaymak | Arzu Yay

Yayıncı: Hacettepe University

Ana Başlıklar: Engineering

Dergi: Hacettepe Journal of Biology and Chemistry Vol.51 Issue 3, pp.259-270

Belge Tipi: Makale

Yayın Tarihi: 7/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293123

pISSN: 2687-475X

Sayı

Yazarlar:

İsmail Bayram Güllü | Sevil Albayrak | Emin Kaymak | Arzu Yay

Yayıncı:

Hacettepe University

Ana Başlıklar:

Engineering

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.51 Issue 3, pp.259-270

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293123

pISSN:

2687-475X