Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

Murat KARCIOĞLU; Kasım TUZCU; Fatih SEFİL; Işıl DAVARCI; Suzan AYDIN; Ali SARI; Akın AYDOĞAN; Raif ÖZDEN

Makale detayları

Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

Yazarlar:

Murat KARCIOĞLU | Kasım TUZCU | Fatih SEFİL | Işıl DAVARCI | Suzan AYDIN | Ali SARI | Akın AYDOĞAN | Raif ÖZDEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.330-336

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753367

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model.  Materials and methods: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed.   Results: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome.   Conclusion: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaine-induced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics.

 

Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model.  Materials and methods: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed.   Results: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome.   Conclusion: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaine-induced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics.

Makale detayları

Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

Yazarlar:

Murat KARCIOĞLU | Kasım TUZCU | Fatih SEFİL | Işıl DAVARCI | Suzan AYDIN | Ali SARI | Akın AYDOĞAN | Raif ÖZDEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.330-336

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753367

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Levobupivacaine

lipid emulsion

epinephrine

toxicity

resuscitation

Sayı

Makale detayları

Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

Yazarlar: Murat KARCIOĞLU | Kasım TUZCU | Fatih SEFİL | Işıl DAVARCI | Suzan AYDIN | Ali SARI | Akın AYDOĞAN | Raif ÖZDEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.330-336

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000753367

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Levobupivacaine

lipid emulsion

epinephrine

toxicity

resuscitation

Sayı

Yazarlar:

Murat KARCIOĞLU | Kasım TUZCU | Fatih SEFİL | Işıl DAVARCI | Suzan AYDIN | Ali SARI | Akın AYDOĞAN | Raif ÖZDEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.330-336

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753367

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144