Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Songül Karakaya; Fatma Gül Delimustafaoğlu; Serap Gur

Makale detayları

Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Yazarlar:

Songül Karakaya | Fatma Gül Delimustafaoğlu | Serap Gur

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.235-241

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346478

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen  Quézel species extracts on corpus cavernosum CC. A totality of 20 adult male Sprague-Dawley rats diabetic and control groups were induced by single intraperitoneal injection of 40 mgkg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine Phe, and relaxation responses relevant to acetylcholine ACh, 1 mM , sodium nitroprusside SNP 0.1 µM  and electrical field stimulation EFS, frequency 20 Hz were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80 and 97.55 relaxation. Among the extracts of roots especially roots of F. mughlae showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part especially F. sandrasica showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

 Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen  Quézel species extracts on corpus cavernosum CC. A totality of 20 adult male Sprague-Dawley rats diabetic and control groups were induced by single intraperitoneal injection of 40 mgkg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine Phe, and relaxation responses relevant to acetylcholine ACh, 1 mM , sodium nitroprusside SNP 0.1 µM  and electrical field stimulation EFS, frequency 20 Hz were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80 and 97.55 relaxation. Among the extracts of roots especially roots of F. mughlae showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part especially F. sandrasica showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

 Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen  Quézel species extracts on corpus cavernosum CC. A totality of 20 adult male Sprague-Dawley rats diabetic and control groups were induced by single intraperitoneal injection of 40 mgkg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine Phe, and relaxation responses relevant to acetylcholine ACh, 1 mM , sodium nitroprusside SNP 0.1 µM  and electrical field stimulation EFS, frequency 20 Hz were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80 and 97.55 relaxation. Among the extracts of roots especially roots of F. mughlae showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part especially F. sandrasica showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

 Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen  Quézel species extracts on corpus cavernosum CC. A totality of 20 adult male Sprague-Dawley rats diabetic and control groups were induced by single intraperitoneal injection of 40 mgkg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine Phe, and relaxation responses relevant to acetylcholine ACh, 1 mM , sodium nitroprusside SNP 0.1 µM  and electrical field stimulation EFS, frequency 20 Hz were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80 and 97.55 relaxation. Among the extracts of roots especially roots of F. mughlae showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part especially F. sandrasica showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

Makale detayları

Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Yazarlar:

Songül Karakaya | Fatma Gül Delimustafaoğlu | Serap Gur

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.235-241

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346478

pISSN:

2630-6344

Aphrodisiacs

Apiaceae

Ferulago

erectile function

Sayı

Makale detayları

Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats

Yazarlar: Songül Karakaya | Fatma Gül Delimustafaoğlu | Serap Gur

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.23 Issue 2, pp.235-241

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346478

pISSN: 2630-6344

Aphrodisiacs

Apiaceae

Ferulago

erectile function

Sayı

Yazarlar:

Songül Karakaya | Fatma Gül Delimustafaoğlu | Serap Gur

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 2, pp.235-241

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346478

pISSN:

2630-6344