Is There Intestinal Mucosal Damage in Calves Exposed to Polypharmacy?

Deniz Alıç Ural

Makale detayları

Is There Intestinal Mucosal Damage in Calves Exposed to Polypharmacy?

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Hayvan Besleme

Dergi:

Bozok Veterinary Sciences Vol.6 Issue 1, pp.22-25

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001350610

pISSN:

2757-5179

Anahtar kelimeler:

Özet:

 This field study was planned retrospectively and was carried out on 59 calves belonging to different farms within the provincial or district borders of Aydın. Each calf included in the study was selected among those who had been subjected to treatment with more than one drug due to diarrhea Group I; n20 andor pneumonia Group II; n20. As a starting criterion, those who had been on multiple drug treatment for at least one week were included. 19 other healthy calves were included in the study as the control group III for comparison. Serum was extracted from blood samples obtained from each calf by expert veterinarians after centrifugation and stored in the freezer. Serum DAO values were determined by competitive enzyme immunoassay technique using commercial Bovine Diamine Oxidase DAO ELISA tests. The meanstandard error DAO ngmL values were determined as 8,22  2,02, 11,44  1,96 and 28,90  3,59 p 0.001 in Groups I, II and III, respectively. As a result, it can be said that intestinal mucosal damage may develop in calves with diarrhea andor pneumonia exposed to polypharmacy for at least 1 week, and this can be detected by decreased DAO levels compared to healthy controls.

 This field study was planned retrospectively and was carried out on 59 calves belonging to different farms within the provincial or district borders of Aydın. Each calf included in the study was selected among those who had been subjected to treatment with more than one drug due to diarrhea Group I; n20 andor pneumonia Group II; n20. As a starting criterion, those who had been on multiple drug treatment for at least one week were included. 19 other healthy calves were included in the study as the control group III for comparison. Serum was extracted from blood samples obtained from each calf by expert veterinarians after centrifugation and stored in the freezer. Serum DAO values were determined by competitive enzyme immunoassay technique using commercial Bovine Diamine Oxidase DAO ELISA tests. The meanstandard error DAO ngmL values were determined as 8,22  2,02, 11,44  1,96 and 28,90  3,59 p 0.001 in Groups I, II and III, respectively. As a result, it can be said that intestinal mucosal damage may develop in calves with diarrhea andor pneumonia exposed to polypharmacy for at least 1 week, and this can be detected by decreased DAO levels compared to healthy controls.

 This field study was planned retrospectively and was carried out on 59 calves belonging to different farms within the provincial or district borders of Aydın. Each calf included in the study was selected among those who had been subjected to treatment with more than one drug due to diarrhea Group I; n20 andor pneumonia Group II; n20. As a starting criterion, those who had been on multiple drug treatment for at least one week were included. 19 other healthy calves were included in the study as the control group III for comparison. Serum was extracted from blood samples obtained from each calf by expert veterinarians after centrifugation and stored in the freezer. Serum DAO values were determined by competitive enzyme immunoassay technique using commercial Bovine Diamine Oxidase DAO ELISA tests. The meanstandard error DAO ngmL values were determined as 8,22  2,02, 11,44  1,96 and 28,90  3,59 p 0.001 in Groups I, II and III, respectively. As a result, it can be said that intestinal mucosal damage may develop in calves with diarrhea andor pneumonia exposed to polypharmacy for at least 1 week, and this can be detected by decreased DAO levels compared to healthy controls.

 Bu saha araştırması retrospektif olarak planlanarak, Aydında il ya da ilçe sınırlarında farklı işletmelere ait 59 buzağıda gerçekleştirilmiştir. Araştırma kapsamında yer alan her buzağı, ishal Grup I; n20 veveya pnömoni GrupII; n20 nedeniyle birden fazla ilaç ile sağaltım denemesine tabi tutulmuş olanlar arasından seçildi. Başlangıç kriteri olarak en az bir haftadır çoklu ilaç uygulamasında bulunulanlar dahil edildi. Karşılaştırmalı olarak sağlıklı 19 diğer buzağı da kontrol grubu III olarak çalışmada yer buldu. Her buzağıda uzman veteriner hekim eli ile elde edilen kan örneklerinden santrifüj sonrası serum çıkartılarak dondurucuda muhafaza edildi. Ticari Bovine Diamin Oksidaz DAO ELISA testleri aracılığında rekabetçi enzim immünoassay tekniği vasıtasıyla serum DAO değerleri saptandı. Sırası ile Grup I, II ve IIIte ortalamastandart hata DAO ngmL değerleri 8,22  2,02, 11,44  1,96 ve 28,90  3,59 p 0.001 olarak tespit edildi. Sonuç olarak polifarmaziye en az 1 hafta maruz kalan ishalli veveya pnömonili buzağılarda intestinal mukozal hasarlanma gelişebileceği, bunun da sağlıklı kontrollere göre azalan DAO seviyeleri ile tespit edilebileceği söylenebilinir.

Makale detayları

Is There Intestinal Mucosal Damage in Calves Exposed to Polypharmacy?

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Hayvan Besleme

Dergi:

Bozok Veterinary Sciences Vol.6 Issue 1, pp.22-25

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001350610

pISSN:

2757-5179

calf

diamine oxidase

intestinal mucosal damage

polypharmacybuzağı

diamin oksidaz

intestinal mukozal hasar

polifarmazi

Sayı

Makale detayları

Yazarlar: Deniz Alıç Ural

Yayıncı: Yozgat Bozok University

Ana Başlıklar: Hayvan Besleme

Dergi: Bozok Veterinary Sciences Vol.6 Issue 1, pp.22-25

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001350610

pISSN: 2757-5179

Sayı

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Hayvan Besleme

Dergi:

Bozok Veterinary Sciences Vol.6 Issue 1, pp.22-25

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001350610

pISSN:

2757-5179