OUT-OF-MIND INHIBITORS OF HUMAN SERUM PARAOXONASE 1 (PON1): AN IN VITRO STUDY

Mustafa Oğuzhan KAYA

doi:https://doi.org/10.23884/mejs.2017.3.1.07

Makale detayları

OUT-OF-MIND INHIBITORS OF HUMAN SERUM PARAOXONASE 1 (PON1): AN IN VITRO STUDY

Yazarlar:

Mustafa Oğuzhan KAYA

Yayıncı:

Bilal GÜMÜŞ

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Middle East Journal of Science 2017 Vol.3 Issue 1, pp.59-68

Belge Tipi:

Makale

Yayın Tarihi:

8/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000564896

Sıklık:

İki Yıllık

eISSN:

2618-6136

DOI:

https://doi.org/10.23884/mejs.2017.3.1.07

Özet:

 





 4-(dimethylamino)benzaldehyde, 3,5-dinitrosalicylic acid, berylliumsulfate tetrahydrate, urea, sodium azide, iron(II)sulfateheptahydrate, 2-thiobarbituric acid, benzidine, and hydrazinium sulfate, which are commonly used in the pharmaceutical industry and medical studies, have been examined as novel type of inhibitors of PON1. PON1 was purified by hydrophobic column of Sepharose-4B-coupled L-tyrosine- 1-naphthylamine. PON1 enzyme activity towards paraoxon substrate was quantified spectrophotometrically. A critical overview of the effects of these nine reagents on PON1 which associated with cardiovascular diseases has been given. The IC50 values were between 1.26×10-4 M and 2.31×10-4 M and benzidine showed the best inhibitory effect (IC50 = 1.26×10-4M) for PON1 enzyme activity. 


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Makale detayları

OUT-OF-MIND INHIBITORS OF HUMAN SERUM PARAOXONASE 1 (PON1): AN IN VITRO STUDY

Yazarlar: Mustafa Oğuzhan KAYA

Yayıncı: Bilal GÜMÜŞ

Ana Başlıklar: Astronomi ve ilgili bilimler

Dergi: Middle East Journal of Science 2017 Vol.3 Issue 1, pp.59-68

Belge Tipi: Makale

Yayın Tarihi: 8/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000564896

Sıklık: İki Yıllık

eISSN: 2618-6136

DOI: https://doi.org/10.23884/mejs.2017.3.1.07

Sayı

Yazarlar:

Mustafa Oğuzhan KAYA

Yayıncı:

Bilal GÜMÜŞ

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Middle East Journal of Science 2017 Vol.3 Issue 1, pp.59-68

Belge Tipi:

Makale

Yayın Tarihi:

8/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000564896

Sıklık:

İki Yıllık

eISSN:

2618-6136

DOI:

https://doi.org/10.23884/mejs.2017.3.1.07