Altered apoptotic protein expressions characterize the survival of Bcr-Abl-independent drug-resistant chronic myeloid leukemia cell line

Seda BAYKAL KÖSE; Pelin YALÇIN

doi:https://doi.org/10.30621/jbachs.848797

Makale detayları

Altered apoptotic protein expressions characterize the survival of Bcr-Abl-independent drug-resistant chronic myeloid leukemia cell line

Yazarlar:

Seda BAYKAL KÖSE | Pelin YALÇIN

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Basic and Clinical Health Sciences 2021 Vol.5 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000493344

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.848797

Özet:

 

Apoptosis is a programmed cellular process that occurs in pathological and physiological pathways and it is one of the most studied topics in cell biology. To understand the underlying mechanism of apoptosis plays an important role in the molecular pathogenesis of many diseases including cancers. Chronic myeloid leukemia (CML) is a clonal myeloproliferative malignancy arising from the neoplastic transformation of the hematopoietic stem cell. Here, we used a Bcr-Abl-independent, imatinib-resistant K562 subpopulation (K562-IR) generated and characterized earlier in our laboratory. We showed that the proteins Bcl-2, Bim, RIP, p-MAPK(Erk1/Erk2) and NF-кB which play critical roles in cell death pathways are downregulated, Lamin A/C protein expression is upregulated in K562-IR derivative cells compared to K562 ancestral cells. Our data provide new information on the expression of apoptotic molecules in a Bcr-Abl-independent imatinib-resistant CML cell line.

Makale detayları

Altered apoptotic protein expressions characterize the survival of Bcr-Abl-independent drug-resistant chronic myeloid leukemia cell line

Yazarlar: Seda BAYKAL KÖSE | Pelin YALÇIN

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Basic and Clinical Health Sciences 2021 Vol.5 Issue 1, pp.1-5

Belge Tipi: Makale

Yayın Tarihi: 2/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000493344

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.30621/jbachs.848797

Sayı

Yazarlar:

Seda BAYKAL KÖSE | Pelin YALÇIN

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Basic and Clinical Health Sciences 2021 Vol.5 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000493344

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.848797