The Anti-Genotoxic Effect of Taurine on Aluminum Sulphate-Induced DNA Damage in Human Peripheral Lymphocytes

Hasan TÜRKEZ; Fatime GEYİKOĞLU

Makale detayları

The Anti-Genotoxic Effect of Taurine on Aluminum Sulphate-Induced DNA Damage in Human Peripheral Lymphocytes

Yazarlar:

Hasan TÜRKEZ | Fatime GEYİKOĞLU

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2010 Vol.69 Issue 1, pp.25-32

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424635

eISSN:

2618-6144

pISSN:

2602-2575

Özet:

 


Aluminum sulphate Al2(SO4)3 is commonly used as a coagulant in the purification of drinking water in many regions of the world. Aluminum (Al) is also involved in several pharmaceutical and cosmetic products. However, Al is suspected to cause serious disorders such as Alzheimer's by oxidative DNA damage. On the other hand, taurine (TA) is an amino acid found in mammalian tissues and it has been suggested to play a role in the defense against cellular damage. The objective of this study was to determine whether the supplemetation of a natural antioxidant, TA conferred the protection against Al exposure in human blood cultures. For this aim, sister chromatid exchange (SCE) and micronucleus (MN) rates were assessed. Present results showed that 10 μg/ml of Al2(SO4)3 has no effect on SCE and MN rates, but 20 μg/ml of this compound increased the rates of SCEs and MN. Besides, the TA at all studied concentrations (25, 50 and 100 μg/ml) did not alter the mean SCE and MN values as compared to controls. Moreover,  the negative cytogenetic alterations induced by Al could be significantly (P<0.05) reduced by the application of TA. This study reveals for the first time the ameliorative role of TA against Al-induced DNA damage in vitro.

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Makale detayları

The Anti-Genotoxic Effect of Taurine on Aluminum Sulphate-Induced DNA Damage in Human Peripheral Lymphocytes

Yazarlar: Hasan TÜRKEZ | Fatime GEYİKOĞLU

Yayıncı: Istanbul University

Dergi: European Journal of Biology 2010 Vol.69 Issue 1, pp.25-32

Belge Tipi: Makale

Yayın Tarihi: 11/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000424635

eISSN: 2618-6144

pISSN: 2602-2575

Sayı

Yazarlar:

Hasan TÜRKEZ | Fatime GEYİKOĞLU

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2010 Vol.69 Issue 1, pp.25-32

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424635

eISSN:

2618-6144

pISSN:

2602-2575