Quality Control Studies on Conventional Carbamazepine Tablets Available on the Turkish Drug Market

Tansel ÇOMOĞLU; Nurşin GÖNÜL

Makale detayları

Quality Control Studies on Conventional Carbamazepine Tablets Available on the Turkish Drug Market

Yazarlar:

Tansel ÇOMOĞLU | Nurşin GÖNÜL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 4, pp.217-221

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756353

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Carbamazepine (CBZ) is a widely used antiepileptic drug. It is used to control grandmal seizure as well as in the treatment of neuralgia. The drug is characterised by slow and irregular gastrointestinal absorption due to its low water solubility. In clinics, for conventional dosage forms of CBZ, single daily dosing is insufficient; effective CBZ level is provided by multiple drug administration. Multiplicity of dosage causes inconsistent plasma CBZ levels leading to side effects because of narrow therapeutic and toxic levels.  In this study, quality controls of different  conventional CBZ tablets which are commercially available on the Turkish drug market were examined. Quality control parameters were weight variations, diameter and thickness, content uniformity, friability and dissolution tests. Differences between conventional CBZ tablets were evaluated.

 

Carbamazepine (CBZ) is a widely used antiepileptic drug. It is used to control grandmal seizure as well as in the treatment of neuralgia. The drug is characterised by slow and irregular gastrointestinal absorption due to its low water solubility. In clinics, for conventional dosage forms of CBZ, single daily dosing is insufficient; effective CBZ level is provided by multiple drug administration. Multiplicity of dosage causes inconsistent plasma CBZ levels leading to side effects because of narrow therapeutic and toxic levels.  In this study, quality controls of different  conventional CBZ tablets which are commercially available on the Turkish drug market were examined. Quality control parameters were weight variations, diameter and thickness, content uniformity, friability and dissolution tests. Differences between conventional CBZ tablets were evaluated.

Makale detayları

Quality Control Studies on Conventional Carbamazepine Tablets Available on the Turkish Drug Market

Yazarlar:

Tansel ÇOMOĞLU | Nurşin GÖNÜL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 4, pp.217-221

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756353

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Conventional carbamazepine tablets

quality control studies

Sayı

Makale detayları

Quality Control Studies on Conventional Carbamazepine Tablets Available on the Turkish Drug Market

Yazarlar: Tansel ÇOMOĞLU | Nurşin GÖNÜL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2005 Vol.35 Issue 4, pp.217-221

Belge Tipi: Makale

Yayın Tarihi: 3/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000756353

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Conventional carbamazepine tablets

quality control studies

Sayı

Yazarlar:

Tansel ÇOMOĞLU | Nurşin GÖNÜL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 4, pp.217-221

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756353

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144