Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

İlkin İyigündoğdu; Eda Derle; Güven Girgin; Sevgi İkbali Afşar; Oya Ümit Yemişçi; Berna Alkan; Seda Kibaroglu; Ülkü Sibel Benli

Makale detayları

Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

Yazarlar:

İlkin İyigündoğdu | Eda Derle | Güven Girgin | Sevgi İkbali Afşar | Oya Ümit Yemişçi | Berna Alkan | Seda Kibaroglu | Ülkü Sibel Benli

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.460-470

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320793

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome GBS patients retrospectively and identify the prognostic factors associated with worse outcome at discharge and at the end of the first month in patients with GBS. Materials and Methods: Patients who were followed up with the diagnosis of GBS were evaluated retrospectively. Demographic characteristics of the patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council MRC and Hughes Motor Scale HMS scores were recorded and HMS 3 was accepted as associated with poor prognosis in patients. SPSS version 25 program was used in the statistical analysis of the data. p0.05 was found to be statistically significant. Results: After the exclusion criteria 82 patients were evaluated in this study. The mean age of patients was 56.8817.14 years and 57.3 n47 of the patients were male. The most common neurological finding was paresis in the lower extremities n67, 81.7 followed by paresis in the upper extremities n48, 58.5. Presence of paresis in lower extremities, the median of the duration of hospitalization and the mean of MRC scores at admission were statistically significantly different in patients with poor prognosis at discharge and at the end of the first month. Conclusion: Since patients may have different clinical and electrophysiological characteristics between countries, we believe that there is a need for various publications from different countries to collect information related to the clinical features and prognosis of patients, and we think our study will contribute to these data.

 Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome GBS patients retrospectively and identify the prognostic factors associated with worse outcome at discharge and at the end of the first month in patients with GBS. Materials and Methods: Patients who were followed up with the diagnosis of GBS were evaluated retrospectively. Demographic characteristics of the patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council MRC and Hughes Motor Scale HMS scores were recorded and HMS 3 was accepted as associated with poor prognosis in patients. SPSS version 25 program was used in the statistical analysis of the data. p0.05 was found to be statistically significant. Results: After the exclusion criteria 82 patients were evaluated in this study. The mean age of patients was 56.8817.14 years and 57.3 n47 of the patients were male. The most common neurological finding was paresis in the lower extremities n67, 81.7 followed by paresis in the upper extremities n48, 58.5. Presence of paresis in lower extremities, the median of the duration of hospitalization and the mean of MRC scores at admission were statistically significantly different in patients with poor prognosis at discharge and at the end of the first month. Conclusion: Since patients may have different clinical and electrophysiological characteristics between countries, we believe that there is a need for various publications from different countries to collect information related to the clinical features and prognosis of patients, and we think our study will contribute to these data.

 Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome GBS patients retrospectively and identify the prognostic factors associated with worse outcome at discharge and at the end of the first month in patients with GBS. Materials and Methods: Patients who were followed up with the diagnosis of GBS were evaluated retrospectively. Demographic characteristics of the patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council MRC and Hughes Motor Scale HMS scores were recorded and HMS 3 was accepted as associated with poor prognosis in patients. SPSS version 25 program was used in the statistical analysis of the data. p0.05 was found to be statistically significant. Results: After the exclusion criteria 82 patients were evaluated in this study. The mean age of patients was 56.8817.14 years and 57.3 n47 of the patients were male. The most common neurological finding was paresis in the lower extremities n67, 81.7 followed by paresis in the upper extremities n48, 58.5. Presence of paresis in lower extremities, the median of the duration of hospitalization and the mean of MRC scores at admission were statistically significantly different in patients with poor prognosis at discharge and at the end of the first month. Conclusion: Since patients may have different clinical and electrophysiological characteristics between countries, we believe that there is a need for various publications from different countries to collect information related to the clinical features and prognosis of patients, and we think our study will contribute to these data.

 Amaç: Bu çalışmada Guillain Barré sendromu GBS olan hastaların klinik özelliklerini retrospektif olarak değerlendirmeyi ve taburculuk ile birinci ayın sonunda kötü prognozla ilişkili prognostik faktörleri belirlemeyi amaçladık. Gereç ve Yöntem: GBS tanısıyla takip edilen hastalar geriye dönük olarak değerlendirildi. Hastaların demografik özellikleri, beyin omurilik sıvısı sonuçları, muayene bulguları, tedavi rejimleri, Medical Research Council MRC ve Hughes Motor Skalası HMS değerleri kaydedildi ve HMS 3 hastalar kötü prognoz ile ilişkili kabul edildi. Verilerin istatistiksel analizinde SPSS versiyon 25 programı kullanıldı. p0.05 istatistiksel olarak anlamlı bulundu. Bulgular: Dışlama kriterleri sonrasında 82 hasta çalışmaya dahil edildi. Hastaların ortalama yaşı 56.8817.14 yıl olup, hastaların 57.3ü n47 erkekti. En sık görülen nörolojik bulgu alt ekstremitede parezi n67, 81.7 iken bunu üst ekstremitede parezi n48, 58.5 izlemekteydi. Alt ekstremitede parezi varlığı, yatış süresi ortancası ve başvuru anındaki MRC skorlarının ortalaması kötü ve iyi prognozlu hastalarda taburculukta ve birinci ay sonunda istatistiksel olarak anlamlı derecede farklıydı. Sonuç: Hastalar ülkeler arasında farklı klinik ve elektrofizyolojik özelliklere sahip olabileceğinden hastaların klinik özellikleri ve prognozlarına ilişkin bilgi toplamak için farklı ülkelerden çeşitli yayınlara ihtiyaç duyulduğunu ve çalışmamızın bu verilere katkı sağlayacağını düşünüyoruz.

Makale detayları

Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

Yazarlar:

İlkin İyigündoğdu | Eda Derle | Güven Girgin | Sevgi İkbali Afşar | Oya Ümit Yemişçi | Berna Alkan | Seda Kibaroglu | Ülkü Sibel Benli

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.460-470

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320793

pISSN:

2602-3032

Guilain Barré syndrome

prognosis

Hughes Motor ScaleGuillain Barré sendromu

prognoz

Hughes Motor Skalası

Sayı

Makale detayları

Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

Yazarlar: İlkin İyigündoğdu | Eda Derle | Güven Girgin | Sevgi İkbali Afşar | Oya Ümit Yemişçi | Berna Alkan | Seda Kibaroglu | Ülkü Sibel Benli

Yayıncı: Cukurova University

Ana Başlıklar: Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Cukurova Medical Journal Vol.49 Issue 2, pp.460-470

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001320793

pISSN: 2602-3032

Guilain Barré syndrome

prognosis

Hughes Motor ScaleGuillain Barré sendromu

prognoz

Hughes Motor Skalası

Sayı

Yazarlar:

İlkin İyigündoğdu | Eda Derle | Güven Girgin | Sevgi İkbali Afşar | Oya Ümit Yemişçi | Berna Alkan | Seda Kibaroglu | Ülkü Sibel Benli

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.460-470

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320793

pISSN:

2602-3032