Platelet Indices in Distinguishing Thrombotic vs Embolic Ischemic Stroke

Suleyman Alpar; Muhammed Furkan Özden; Ali Cankut Tatliparmak; Gülbin Aydoğdu Umaç; Sarper Yılmaz

Makale detayları

Platelet Indices in Distinguishing Thrombotic vs Embolic Ischemic Stroke

Yazarlar:

Suleyman Alpar | Muhammed Furkan Özden | Ali Cankut Tatliparmak | Gülbin Aydoğdu Umaç | Sarper Yılmaz

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 2, pp.296-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352247

pISSN:

2147-9607

Anahtar kelimeler:

Özet:

 Aim; Ischemic stroke, a critical condition, can be categorized into thrombotic and embolic subtypes. Understanding the differences in platelet indices between these subtypes can provide valuable insights. Method; This cross-sectional study included patients diagnosed with acute ischemic stroke in the emergency department. Thrombotic and embolic subtypes were compared in terms of demographics, comorbidities, blood results and platelet indices. The primary outcome of the study was comparison of platelet indices between thrombotic and embolic ischemic stroke patients. Results; The study included a total of 233 patients, with 130 55.8 diagnosed with thrombotic ischemic stroke and 103 44.2 with embolic ischemic stroke. Thrombotic stroke patients were older in age p0.01, had higher rates of coronary artery disease p0.019. But the embolic stroke patients and higher rate of atrial fibrillation p0.001. Thrombotic stroke cases demonstrated significantly higher platelet distribution width PDW values 17 16.3  17.8 vs. 13.7 11.8  16, p  0.001 and mean platelet volume MPV values 10.8  1.4 vs. 9.71  1.24, p  0.001 compared to embolic stroke cases. The platelet count p0.352 and plateletcrit p0.106 did not differ significantly among groups. Conclusion; This study reveals distinctive platelet index patterns between thrombotic and embolic ischemic stroke subtypes. While PDW and MPV were higher in thrombotic patients, platelet count and plateletcrit were not significantly different between groups. The findings suggest a potential association between elevated PDW and MPV values and heightened platelet activation in thrombotic strokes.

 Aim; Ischemic stroke, a critical condition, can be categorized into thrombotic and embolic subtypes. Understanding the differences in platelet indices between these subtypes can provide valuable insights. Method; This cross-sectional study included patients diagnosed with acute ischemic stroke in the emergency department. Thrombotic and embolic subtypes were compared in terms of demographics, comorbidities, blood results and platelet indices. The primary outcome of the study was comparison of platelet indices between thrombotic and embolic ischemic stroke patients. Results; The study included a total of 233 patients, with 130 55.8 diagnosed with thrombotic ischemic stroke and 103 44.2 with embolic ischemic stroke. Thrombotic stroke patients were older in age p0.01, had higher rates of coronary artery disease p0.019. But the embolic stroke patients and higher rate of atrial fibrillation p0.001. Thrombotic stroke cases demonstrated significantly higher platelet distribution width PDW values 17 16.3  17.8 vs. 13.7 11.8  16, p  0.001 and mean platelet volume MPV values 10.8  1.4 vs. 9.71  1.24, p  0.001 compared to embolic stroke cases. The platelet count p0.352 and plateletcrit p0.106 did not differ significantly among groups. Conclusion; This study reveals distinctive platelet index patterns between thrombotic and embolic ischemic stroke subtypes. While PDW and MPV were higher in thrombotic patients, platelet count and plateletcrit were not significantly different between groups. The findings suggest a potential association between elevated PDW and MPV values and heightened platelet activation in thrombotic strokes.

 Aim; Ischemic stroke, a critical condition, can be categorized into thrombotic and embolic subtypes. Understanding the differences in platelet indices between these subtypes can provide valuable insights. Method; This cross-sectional study included patients diagnosed with acute ischemic stroke in the emergency department. Thrombotic and embolic subtypes were compared in terms of demographics, comorbidities, blood results and platelet indices. The primary outcome of the study was comparison of platelet indices between thrombotic and embolic ischemic stroke patients. Results; The study included a total of 233 patients, with 130 55.8 diagnosed with thrombotic ischemic stroke and 103 44.2 with embolic ischemic stroke. Thrombotic stroke patients were older in age p0.01, had higher rates of coronary artery disease p0.019. But the embolic stroke patients and higher rate of atrial fibrillation p0.001. Thrombotic stroke cases demonstrated significantly higher platelet distribution width PDW values 17 16.3  17.8 vs. 13.7 11.8  16, p  0.001 and mean platelet volume MPV values 10.8  1.4 vs. 9.71  1.24, p  0.001 compared to embolic stroke cases. The platelet count p0.352 and plateletcrit p0.106 did not differ significantly among groups. Conclusion; This study reveals distinctive platelet index patterns between thrombotic and embolic ischemic stroke subtypes. While PDW and MPV were higher in thrombotic patients, platelet count and plateletcrit were not significantly different between groups. The findings suggest a potential association between elevated PDW and MPV values and heightened platelet activation in thrombotic strokes.

 Giriş ve Amaç: Kritik bir klinik tablo olan iskemik inme, trombotik ve embolik alt tipler olarak sınıflandırılabilir. Bu alt tipler arasındaki trombosit indekslerindeki farklılıkların anlaşılması, önemli bilgiler sağlayabilir. Gereç ve Yöntemler: Bu kesitsel çalışmaya, acil serviste akut iskemik inme tanısı almış hastalar dahil edilmiştir. Trombotik ve embolik alt tipler; demografik özellikler, eşlik eden hastalıklar, kan test sonuçları ve trombosit indeksleri açısından karşılaştırılmıştır. Çalışmanın birincil çıktısı, trombotik ve embolik iskemik inme hastaları arasında trombosit indekslerinin karşılaştırılmasıdır. Bulgular: Çalışmaya toplam 233 hasta dahil edilmiş olup, bunların 130u 55,8 trombotik, 103ü 44,2 embolik iskemik inme tanısı almıştır. Trombotik inme hastaları daha ileri yaşta bulunmuş p0,01 ve koroner arter hastalığı sıklığı daha yüksek saptanmıştır p0,019. Öte yandan, embolik inme hastalarında atriyal fibrilasyon oranı anlamlı derecede daha yüksek bulunmuştur p0,001. Trombotik inme olgularında trombosit dağılım genişliği PDW 17 16,3  17,8 vs. 13,7 11,8  16, p0,001 ve ortalama trombosit hacmi MPV 10,8  1,4 vs. 9,71  1,24, p0,001 değerleri, embolik inme olgularına kıyasla anlamlı derecede yüksek bulunmuştur. Trombosit sayısı p0,352 ve plateletkrit p0,106 değerleri ise gruplar arasında anlamlı farklılık göstermemiştir. Sonuç: Bu çalışma, trombotik ve embolik iskemik inme alt tipleri arasında belirgin trombosit indeks desenleri olduğunu ortaya koymaktadır. PDW ve MPV değerleri trombotik inme hastalarında daha yüksek saptanırken, trombosit sayısı ve plateletkrit açısından anlamlı fark gözlenmemiştir. Elde edilen bulgular, PDW ve MPV değerlerindeki artışın trombotik inmelerde artmış trombosit aktivasyonu ile ilişkili olabileceğini düşündürmektedir.

Makale detayları

Platelet Indices in Distinguishing Thrombotic vs Embolic Ischemic Stroke

Yazarlar:

Suleyman Alpar | Muhammed Furkan Özden | Ali Cankut Tatliparmak | Gülbin Aydoğdu Umaç | Sarper Yılmaz

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 2, pp.296-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352247

pISSN:

2147-9607

Ischemic stroke

thrombotic stroke

embolic stroke

platelet indices

stroke classification

mean platelet volume

platelet distribution width

stroke pathophysiologyİskemik inme

trombotik inme

embolik inme

trombosit indeksleri

inme sınıflandırması

ortalama trombosit hacmi

trombosit dağılım genişliği

inme patofizyolojisi

Sayı

Makale detayları

Yazarlar: Suleyman Alpar | Muhammed Furkan Özden | Ali Cankut Tatliparmak | Gülbin Aydoğdu Umaç | Sarper Yılmaz

Yayıncı: Manisa Celal Bayar University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 2, pp.296-304

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001352247

pISSN: 2147-9607

Sayı

Yazarlar:

Suleyman Alpar | Muhammed Furkan Özden | Ali Cankut Tatliparmak | Gülbin Aydoğdu Umaç | Sarper Yılmaz

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.12 Issue 2, pp.296-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352247

pISSN:

2147-9607