Effect of Adriamycin Administered via Different Routes on Ehrlich Ascites Tumor Cells

Hatice GÜMÜŞHAN; Davut MUSA

Makale detayları

Effect of Adriamycin Administered via Different Routes on Ehrlich Ascites Tumor Cells

Yazarlar:

Hatice GÜMÜŞHAN | Davut MUSA

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2008 Vol.67 Issue 1, pp.49-54

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424688

eISSN:

2618-6144

pISSN:

2602-2575

Özet:

 


 

Adriamycin (ADR) is an antineoplastic drug, isolated from Streptomyces peucetius var. caesius, and has cytotoxic features. It binds DNA by intercalation and inhibits replication and transcription. Clinically, ADR is used intravenously and intravesically. Ehrlich ascites tumor (EAT) was originated from breast carcinoma in a mouse. It grows in solid and ascitic forms. The aim of our study is to investigate the effectiveness of ADR on mice bearing EAT by comparing its administration routes. 0.01 mg.g-1 ADR was administered mice bearing EAT via intraperitoneal, intravenous and subcutaneous. On day 0 each mouse in the experiment was inoculated with 3x105 EAT cells. On the 2nd, 4th, 6th, 8th days after administration, number of viable cells and mitosis number were counted from each animal by drainage the ascites fluid from the peritoneal cavity of each mouse. Data were evaluated statistically. The most efficient in respect of curing properties was observed in group I in which ADR administered via intraperitoneal. 

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Makale detayları

Effect of Adriamycin Administered via Different Routes on Ehrlich Ascites Tumor Cells

Yazarlar: Hatice GÜMÜŞHAN | Davut MUSA

Yayıncı: Istanbul University

Dergi: European Journal of Biology 2008 Vol.67 Issue 1, pp.49-54

Belge Tipi: Makale

Yayın Tarihi: 11/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000424688

eISSN: 2618-6144

pISSN: 2602-2575

Sayı

Yazarlar:

Hatice GÜMÜŞHAN | Davut MUSA

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2008 Vol.67 Issue 1, pp.49-54

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424688

eISSN:

2618-6144

pISSN:

2602-2575