The Possible Role of The Glucose-6-Phosphate Dehydrogenase Enzyme Deficiency in The Polyneuropathies

Duygu AYDEMİR; Nuriye Nuray ULUSU

doi:https://doi.org/10.30621/jbachs.2020.1151

Makale detayları

The Possible Role of The Glucose-6-Phosphate Dehydrogenase Enzyme Deficiency in The Polyneuropathies

Yazarlar:

Duygu AYDEMİR | Nuriye Nuray ULUSU

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.212-217

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493398

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.1151

Özet:

 

Glucose is the main energy source of the various types of cells and largely metabolized by either glycolysis or pentose phosphate pathway   PPP . Glucose-6-phosphate dehydrogenase  G6PD, glucose 6-phosphate  G6P : NADP  +  oxidoreductase, EC 1.1.1.49  is the first and rate  limiting enzyme of the oxidative branch of the PPP. This enzyme found in many species from bacteria to humans and is found in all cell types.  G6PD deficiency is the most common enzyme deficiency affecting 400 million people worldwide. However, moderate G6PD deficiency may  not give symptoms but can lead to various neurological and neurodegenerative disorders including polyneuropathies. Both inflammation and  oxidative stress play a major role in the formation of the neurological disorders, however, G6PD gives advantage to brain and nerve cells to fight  against oxidative stress, neurodegeneration, neuronal survival and aging. In conclusion, G6PD plays vital role to maintain homeostasis of lipid,  redox and energy metabolisms. Thus, impairment in the G6PD activity may cause elevated levels of oxidative stress involved in the formation  of the neurodegeneration and may involve in the primary cause of idiopathic sensory-motor polyneuropathy.

Makale detayları

The Possible Role of The Glucose-6-Phosphate Dehydrogenase Enzyme Deficiency in The Polyneuropathies

Yazarlar: Duygu AYDEMİR | Nuriye Nuray ULUSU

Yayıncı: Dokuz Eylul University

Dergi: Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.212-217

Belge Tipi: Makale

Yayın Tarihi: 8/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000493398

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.30621/jbachs.2020.1151

Sayı

Yazarlar:

Duygu AYDEMİR | Nuriye Nuray ULUSU

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2020 Vol.4 Issue 3, pp.212-217

Belge Tipi:

Makale

Yayın Tarihi:

8/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493398

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.2020.1151