Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase

Umar Faruk Magaji; Özlem Saçan; Refiye Yanardağ

Makale detayları

Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase

Yazarlar:

Umar Faruk Magaji | Özlem Saçan | Refiye Yanardağ

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 3, pp.314-319

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001311549

pISSN:

2587-2087

Anahtar kelimeler:

Özet:

 Background and Aims: The use of Moringa oleifera as nutraceuticals in alternative medicine has received tremendous attention in recent years. Its diverse bioactive composition, multipurpose benefits and ease of cultivation give it a superior advantage over other herbs. Methods: Fresh leaves and roots were obtained from M. oleifera grown in northwestern Nigeria. The inhibitory effect of M. oleifera extracts on the activities of neuraminidase, xanthine oxidase, and adenosine deaminase were determined. Results: The present study explored the aqueous, methanol, and hexane extract of M. oleifera leaves and roots for the inhibition of neuraminidase, xanthine oxidase, and adenosine deaminase. In comparison to quercetin Half maximum inhibitory concentration IC50  14.28  2.30 μgmL, aqueous IC50 0.12  0.01 μgmL and methanol IC50  0.57  0.13 μgmL the extract of the moringa root strongly inhibited neuraminidase activity. The enzyme was moderately inhibited by aqueous IC50  89.56  9.77 μgmL and hexane IC50  104.33  3.39 μgmL extracts of the plant leaf. The inhibition of xanthine oxidase by aqueous IC50  7543.86  1127.19 μgmL, and methanol IC50  1779.48  126.50 μgmL leaf extracts were far below that of a standard inhibitor - allopurinol IC50  0.88  0.01 μgmL. Amongst the extracts used, only the hexane extract of the moringa leaf IC50  4580.38  75.69 μgmL inhibited adenosine deaminase and was less effective than erythro-9-2-Hydroxy-3-nonyl-adenine hydrochloride EHNA IC50  53.00  1.83 μgmL. Conclusion: The findings suggest that moringa roots and leaves can be an excellent source of agents against microbial infection and viral induced respiratory syndrome. The extracts may also attenuate influenza A infection, the progression of oxidative stress, cancer, inflammation, diabetes, cardiac failure, and coronary artery disease, since they have an effect on neuraminidase, xanthine oxidase, adenosine deaminase, and possibly superoxide levels.

 Background and Aims: The use of Moringa oleifera as nutraceuticals in alternative medicine has received tremendous attention in recent years. Its diverse bioactive composition, multipurpose benefits and ease of cultivation give it a superior advantage over other herbs. Methods: Fresh leaves and roots were obtained from M. oleifera grown in northwestern Nigeria. The inhibitory effect of M. oleifera extracts on the activities of neuraminidase, xanthine oxidase, and adenosine deaminase were determined. Results: The present study explored the aqueous, methanol, and hexane extract of M. oleifera leaves and roots for the inhibition of neuraminidase, xanthine oxidase, and adenosine deaminase. In comparison to quercetin Half maximum inhibitory concentration IC50  14.28  2.30 μgmL, aqueous IC50 0.12  0.01 μgmL and methanol IC50  0.57  0.13 μgmL the extract of the moringa root strongly inhibited neuraminidase activity. The enzyme was moderately inhibited by aqueous IC50  89.56  9.77 μgmL and hexane IC50  104.33  3.39 μgmL extracts of the plant leaf. The inhibition of xanthine oxidase by aqueous IC50  7543.86  1127.19 μgmL, and methanol IC50  1779.48  126.50 μgmL leaf extracts were far below that of a standard inhibitor - allopurinol IC50  0.88  0.01 μgmL. Amongst the extracts used, only the hexane extract of the moringa leaf IC50  4580.38  75.69 μgmL inhibited adenosine deaminase and was less effective than erythro-9-2-Hydroxy-3-nonyl-adenine hydrochloride EHNA IC50  53.00  1.83 μgmL. Conclusion: The findings suggest that moringa roots and leaves can be an excellent source of agents against microbial infection and viral induced respiratory syndrome. The extracts may also attenuate influenza A infection, the progression of oxidative stress, cancer, inflammation, diabetes, cardiac failure, and coronary artery disease, since they have an effect on neuraminidase, xanthine oxidase, adenosine deaminase, and possibly superoxide levels.

 Background and Aims: The use of Moringa oleifera as nutraceuticals in alternative medicine has received tremendous attention in recent years. Its diverse bioactive composition, multipurpose benefits and ease of cultivation give it a superior advantage over other herbs. Methods: Fresh leaves and roots were obtained from M. oleifera grown in northwestern Nigeria. The inhibitory effect of M. oleifera extracts on the activities of neuraminidase, xanthine oxidase, and adenosine deaminase were determined. Results: The present study explored the aqueous, methanol, and hexane extract of M. oleifera leaves and roots for the inhibition of neuraminidase, xanthine oxidase, and adenosine deaminase. In comparison to quercetin Half maximum inhibitory concentration IC50  14.28  2.30 μgmL, aqueous IC50 0.12  0.01 μgmL and methanol IC50  0.57  0.13 μgmL the extract of the moringa root strongly inhibited neuraminidase activity. The enzyme was moderately inhibited by aqueous IC50  89.56  9.77 μgmL and hexane IC50  104.33  3.39 μgmL extracts of the plant leaf. The inhibition of xanthine oxidase by aqueous IC50  7543.86  1127.19 μgmL, and methanol IC50  1779.48  126.50 μgmL leaf extracts were far below that of a standard inhibitor - allopurinol IC50  0.88  0.01 μgmL. Amongst the extracts used, only the hexane extract of the moringa leaf IC50  4580.38  75.69 μgmL inhibited adenosine deaminase and was less effective than erythro-9-2-Hydroxy-3-nonyl-adenine hydrochloride EHNA IC50  53.00  1.83 μgmL. Conclusion: The findings suggest that moringa roots and leaves can be an excellent source of agents against microbial infection and viral induced respiratory syndrome. The extracts may also attenuate influenza A infection, the progression of oxidative stress, cancer, inflammation, diabetes, cardiac failure, and coronary artery disease, since they have an effect on neuraminidase, xanthine oxidase, adenosine deaminase, and possibly superoxide levels.

 Background and Aims: The use of Moringa oleifera as nutraceuticals in alternative medicine has received tremendous attention in recent years. Its diverse bioactive composition, multipurpose benefits and ease of cultivation give it a superior advantage over other herbs. Methods: Fresh leaves and roots were obtained from M. oleifera grown in northwestern Nigeria. The inhibitory effect of M. oleifera extracts on the activities of neuraminidase, xanthine oxidase, and adenosine deaminase were determined. Results: The present study explored the aqueous, methanol, and hexane extract of M. oleifera leaves and roots for the inhibition of neuraminidase, xanthine oxidase, and adenosine deaminase. In comparison to quercetin Half maximum inhibitory concentration IC50  14.28  2.30 μgmL, aqueous IC50 0.12  0.01 μgmL and methanol IC50  0.57  0.13 μgmL the extract of the moringa root strongly inhibited neuraminidase activity. The enzyme was moderately inhibited by aqueous IC50  89.56  9.77 μgmL and hexane IC50  104.33  3.39 μgmL extracts of the plant leaf. The inhibition of xanthine oxidase by aqueous IC50  7543.86  1127.19 μgmL, and methanol IC50  1779.48  126.50 μgmL leaf extracts were far below that of a standard inhibitor - allopurinol IC50  0.88  0.01 μgmL. Amongst the extracts used, only the hexane extract of the moringa leaf IC50  4580.38  75.69 μgmL inhibited adenosine deaminase and was less effective than erythro-9-2-Hydroxy-3-nonyl-adenine hydrochloride EHNA IC50  53.00  1.83 μgmL. Conclusion: The findings suggest that moringa roots and leaves can be an excellent source of agents against microbial infection and viral induced respiratory syndrome. The extracts may also attenuate influenza A infection, the progression of oxidative stress, cancer, inflammation, diabetes, cardiac failure, and coronary artery disease, since they have an effect on neuraminidase, xanthine oxidase, adenosine deaminase, and possibly superoxide levels.

Makale detayları

Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase

Yazarlar:

Umar Faruk Magaji | Özlem Saçan | Refiye Yanardağ

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 3, pp.314-319

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001311549

pISSN:

2587-2087

Moringa oleifera

Neuraminidase

Xanthine oxidase

Adenosine deaminase

Inhibition

Sayı

Makale detayları

Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase

Yazarlar: Umar Faruk Magaji | Özlem Saçan | Refiye Yanardağ

Yayıncı: Istanbul University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: İstanbul Journal of Pharmacy Vol.53 Issue 3, pp.314-319

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001311549

pISSN: 2587-2087

Moringa oleifera

Neuraminidase

Xanthine oxidase

Adenosine deaminase

Inhibition

Sayı

Yazarlar:

Umar Faruk Magaji | Özlem Saçan | Refiye Yanardağ

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 3, pp.314-319

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001311549

pISSN:

2587-2087