Sub-chronic Toxicity: Biochemical and Histopathological Profiling of Cincalok Oil in Wistar Rats

N.A.

Makale detayları

Sub-chronic Toxicity: Biochemical and Histopathological Profiling of Cincalok Oil in Wistar Rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.1253-1264

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347039

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Cincalok is a fermented shrimp from West Kalimantan, Indonesia, which has many beneficial compounds such as omega-3 and astaxanthin. The LD50 of the cincalok oil was more than 5000 mg Kg BW practically non-toxic, so there is an opportunity that cincalok can develop into a supplement. However, single and repeated doses may have different toxic potential. This study aimed to observe the sub-chronic toxicity of cincalok oil in Wistar strain rats Rattus norvegicus L. after 28 days of repeat doses in oral administration based on OECD 407 test guidelines. Thirty of the male and female Wistar strain rats were divided into six groups respectively that consisted of one control group of Virgin Coconut Oil VCO administration, three dosing groups of cincalok oil administration with dose variation of 100, 400, and 1000 mgKg BW, and two satellite groups of 1000 mgKg BW dose of cincalok oil administration and VCO control administration. The biochemistry and histopathological investigation was performed. The results showed the biochemical profiles of cincalok oil has no effect on LDL, urea, creatinine, serum glutamate oxaloacetate transaminase, and serum glutamate pyruvate transaminase blood profiles. While on total cholesterol, triglycerides, and HDL profiles, it has reversible effect. Histopathological investigation showed minimal fat degeneration with little congestion and necrosis in the liver, hypertrophy, and hypercholesterolemia in the heart, hydropic degeneration in the kidney, and no disturbance was found in the lung and spleen. Based on biochemical and histopathological result showed that cincalok had no toxic effect and potential to be developed as drug.

 Cincalok is a fermented shrimp from West Kalimantan, Indonesia, which has many beneficial compounds such as omega-3 and astaxanthin. The LD50 of the cincalok oil was more than 5000 mg Kg BW practically non-toxic, so there is an opportunity that cincalok can develop into a supplement. However, single and repeated doses may have different toxic potential. This study aimed to observe the sub-chronic toxicity of cincalok oil in Wistar strain rats Rattus norvegicus L. after 28 days of repeat doses in oral administration based on OECD 407 test guidelines. Thirty of the male and female Wistar strain rats were divided into six groups respectively that consisted of one control group of Virgin Coconut Oil VCO administration, three dosing groups of cincalok oil administration with dose variation of 100, 400, and 1000 mgKg BW, and two satellite groups of 1000 mgKg BW dose of cincalok oil administration and VCO control administration. The biochemistry and histopathological investigation was performed. The results showed the biochemical profiles of cincalok oil has no effect on LDL, urea, creatinine, serum glutamate oxaloacetate transaminase, and serum glutamate pyruvate transaminase blood profiles. While on total cholesterol, triglycerides, and HDL profiles, it has reversible effect. Histopathological investigation showed minimal fat degeneration with little congestion and necrosis in the liver, hypertrophy, and hypercholesterolemia in the heart, hydropic degeneration in the kidney, and no disturbance was found in the lung and spleen. Based on biochemical and histopathological result showed that cincalok had no toxic effect and potential to be developed as drug.

 Cincalok is a fermented shrimp from West Kalimantan, Indonesia, which has many beneficial compounds such as omega-3 and astaxanthin. The LD50 of the cincalok oil was more than 5000 mg Kg BW practically non-toxic, so there is an opportunity that cincalok can develop into a supplement. However, single and repeated doses may have different toxic potential. This study aimed to observe the sub-chronic toxicity of cincalok oil in Wistar strain rats Rattus norvegicus L. after 28 days of repeat doses in oral administration based on OECD 407 test guidelines. Thirty of the male and female Wistar strain rats were divided into six groups respectively that consisted of one control group of Virgin Coconut Oil VCO administration, three dosing groups of cincalok oil administration with dose variation of 100, 400, and 1000 mgKg BW, and two satellite groups of 1000 mgKg BW dose of cincalok oil administration and VCO control administration. The biochemistry and histopathological investigation was performed. The results showed the biochemical profiles of cincalok oil has no effect on LDL, urea, creatinine, serum glutamate oxaloacetate transaminase, and serum glutamate pyruvate transaminase blood profiles. While on total cholesterol, triglycerides, and HDL profiles, it has reversible effect. Histopathological investigation showed minimal fat degeneration with little congestion and necrosis in the liver, hypertrophy, and hypercholesterolemia in the heart, hydropic degeneration in the kidney, and no disturbance was found in the lung and spleen. Based on biochemical and histopathological result showed that cincalok had no toxic effect and potential to be developed as drug.

 Cincalok is a fermented shrimp from West Kalimantan, Indonesia, which has many beneficial compounds such as omega-3 and astaxanthin. The LD50 of the cincalok oil was more than 5000 mg Kg BW practically non-toxic, so there is an opportunity that cincalok can develop into a supplement. However, single and repeated doses may have different toxic potential. This study aimed to observe the sub-chronic toxicity of cincalok oil in Wistar strain rats Rattus norvegicus L. after 28 days of repeat doses in oral administration based on OECD 407 test guidelines. Thirty of the male and female Wistar strain rats were divided into six groups respectively that consisted of one control group of Virgin Coconut Oil VCO administration, three dosing groups of cincalok oil administration with dose variation of 100, 400, and 1000 mgKg BW, and two satellite groups of 1000 mgKg BW dose of cincalok oil administration and VCO control administration. The biochemistry and histopathological investigation was performed. The results showed the biochemical profiles of cincalok oil has no effect on LDL, urea, creatinine, serum glutamate oxaloacetate transaminase, and serum glutamate pyruvate transaminase blood profiles. While on total cholesterol, triglycerides, and HDL profiles, it has reversible effect. Histopathological investigation showed minimal fat degeneration with little congestion and necrosis in the liver, hypertrophy, and hypercholesterolemia in the heart, hydropic degeneration in the kidney, and no disturbance was found in the lung and spleen. Based on biochemical and histopathological result showed that cincalok had no toxic effect and potential to be developed as drug.

Makale detayları

Sub-chronic Toxicity: Biochemical and Histopathological Profiling of Cincalok Oil in Wistar Rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.1253-1264

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347039

pISSN:

2630-6344

Blood biochemistry

Histopathology

Cincalok oil

Sub-chronic toxicity for 28 days

Wistar rats

Sayı

Makale detayları

Sub-chronic Toxicity: Biochemical and Histopathological Profiling of Cincalok Oil in Wistar Rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.28 Issue 4, pp.1253-1264

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347039

pISSN: 2630-6344

Blood biochemistry

Histopathology

Cincalok oil

Sub-chronic toxicity for 28 days

Wistar rats

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.1253-1264

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347039

pISSN:

2630-6344