PRESENCE OF POSTOPERATIVE HISTOPATHOLOGICAL MALIGNANCY IN PATIENTS WITH ATYPIA OF UNDETERMINED SIGNIFICANCE

Salim İlksen Başçeken; Deniz Tikici

Makale detayları

PRESENCE OF POSTOPERATIVE HISTOPATHOLOGICAL MALIGNANCY IN PATIENTS WITH ATYPIA OF UNDETERMINED SIGNIFICANCE

Yazarlar:

Salim İlksen Başçeken | Deniz Tikici

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Surgery

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.119-122

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001285085

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective Thyroid cancer is the most common endocrine Malignancy, and nodules characterize its clinical presentation. Atypia of undetermined significance AUS in biopsies performed for thyroid pathologies is an essential concern for clinicians due to different malignancy rates in the literature. In this study, we aimed to discuss the malignancy rates in patients who underwent thyroid surgery for AUS. Material and Method The demographic and histopathologic data of 174 patients diagnosed with AUS on fine needle aspiration biopsy FNAB and who underwent thyroid surgery in our clinic between 2016 and 2021 were retrospectively analyzed. According to histopathologic features, patients were divided into two groups, malignant and benign, and the relationship with age, gender, and nodule diameter was investigated. Statistical significance between groups was determined using Chi-square and Student t-tests. P value 0.05 was accepted. Results The mean age was 47.912 years range, 20-81. The malignancy rate was 43.5. Malignancy was detected in 42.1 of females and 50 of males. The mean nodule diameter was 19.113.7 mm range, 1-97 mm. There was no statistically significant difference between gender, age, nodule diameter, and Malignancy p0.05. Conclusion According to the Bethesda classification, the malignancy rate for AUS is 15-30. In our study, the malignancy rate was 43.5, similar to studies published in our country. Because of the high malignancy rate, total thyroidectomy should be considered an alternative to lobectomy in cases planned for surgery with a diagnosis of AUS.

 Objective Thyroid cancer is the most common endocrine Malignancy, and nodules characterize its clinical presentation. Atypia of undetermined significance AUS in biopsies performed for thyroid pathologies is an essential concern for clinicians due to different malignancy rates in the literature. In this study, we aimed to discuss the malignancy rates in patients who underwent thyroid surgery for AUS. Material and Method The demographic and histopathologic data of 174 patients diagnosed with AUS on fine needle aspiration biopsy FNAB and who underwent thyroid surgery in our clinic between 2016 and 2021 were retrospectively analyzed. According to histopathologic features, patients were divided into two groups, malignant and benign, and the relationship with age, gender, and nodule diameter was investigated. Statistical significance between groups was determined using Chi-square and Student t-tests. P value 0.05 was accepted. Results The mean age was 47.912 years range, 20-81. The malignancy rate was 43.5. Malignancy was detected in 42.1 of females and 50 of males. The mean nodule diameter was 19.113.7 mm range, 1-97 mm. There was no statistically significant difference between gender, age, nodule diameter, and Malignancy p0.05. Conclusion According to the Bethesda classification, the malignancy rate for AUS is 15-30. In our study, the malignancy rate was 43.5, similar to studies published in our country. Because of the high malignancy rate, total thyroidectomy should be considered an alternative to lobectomy in cases planned for surgery with a diagnosis of AUS.

 Objective Thyroid cancer is the most common endocrine Malignancy, and nodules characterize its clinical presentation. Atypia of undetermined significance AUS in biopsies performed for thyroid pathologies is an essential concern for clinicians due to different malignancy rates in the literature. In this study, we aimed to discuss the malignancy rates in patients who underwent thyroid surgery for AUS. Material and Method The demographic and histopathologic data of 174 patients diagnosed with AUS on fine needle aspiration biopsy FNAB and who underwent thyroid surgery in our clinic between 2016 and 2021 were retrospectively analyzed. According to histopathologic features, patients were divided into two groups, malignant and benign, and the relationship with age, gender, and nodule diameter was investigated. Statistical significance between groups was determined using Chi-square and Student t-tests. P value 0.05 was accepted. Results The mean age was 47.912 years range, 20-81. The malignancy rate was 43.5. Malignancy was detected in 42.1 of females and 50 of males. The mean nodule diameter was 19.113.7 mm range, 1-97 mm. There was no statistically significant difference between gender, age, nodule diameter, and Malignancy p0.05. Conclusion According to the Bethesda classification, the malignancy rate for AUS is 15-30. In our study, the malignancy rate was 43.5, similar to studies published in our country. Because of the high malignancy rate, total thyroidectomy should be considered an alternative to lobectomy in cases planned for surgery with a diagnosis of AUS.

 Amaç Tiroid kanseri en sık görülen endokrin malignitesidir ve klinik görünümü nodüllerle karakterizedir. Tiroid patolojileri için yapılan biyopsilerde Önemi belirsiz atipi ÖBA literatürdeki farklı malignite oranları nedeniyle klinisyenler için önemli bir endişe kaynağıdır. Bu çalışmada, AUS tanısı alan ve tiroid cerrahisi geçiren hastalarda malignite oranlarını güncel literatür ışığında sunmayı amaçladık. Gereç ve Yöntem 2016-2021 yılları arasında kliniğimizde ince iğne aspirasyon biyopsisinde İİAB ÖBA tanısı alan ve tiroid cerrahisi uygulanan 174 hastanın demografik ve histopatolojik verileri retrospektif olarak analiz edildi. Hastalar histopatolojik özelliklerine göre malign ve benign olarak iki gruba ayrıldı. Gruplar arasındaki istatistiksel anlamlılık Ki-kare ve Student t-testleri kullanılarak belirlenmiştir. P değeri 0.05 olarak kabul edilmiştir. Bulgular Yaş ortalaması 47.912 yıl dağılım, 20-81 idi. Malignite oranı 43,5 idi. Kadınların 42,1inde, erkeklerin ise 50sinde malignite tespit edildi. Ortalama nodül çapı 19,113,7 mm 1-97 mm idi. Cinsiyet, yaş ve nodül çapı ile malignite arasında istatistiksel olarak anlamlı ilişki saptanmadı p0.05. Sonuç Bethesda sınıflamasına göre ÖBA için malignite oranı 15-30 olarak belirtilmiştir. Çalışmamızda malignite oranı, ülkemizde yapılan benzer çalışmalara benzer olarak, 43.5 saptanmıştır. ÖBA tanısıyla tiroid cerrahisi planlanan vakalarda, yüksek malignite olasılığı nedeniyle, lobektomiye alternatif olarak total tiroidektomi de bir seçenek olarak düşünülmelidir.

Makale detayları

PRESENCE OF POSTOPERATIVE HISTOPATHOLOGICAL MALIGNANCY IN PATIENTS WITH ATYPIA OF UNDETERMINED SIGNIFICANCE

Yazarlar:

Salim İlksen Başçeken | Deniz Tikici

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Surgery

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.119-122

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001285085

pISSN:

1300-7416

ATA guideline

Atypia of undetermined significance

Bethesda Classification

FNAB

Thyroid malignancy

ATA kılavuzu

Bethesda sınıflaması

İİAB

Önemi belirsiz atipi

Tiroid kanseri

Sayı

Makale detayları

Yazarlar: Salim İlksen Başçeken | Deniz Tikici

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Surgery

Dergi: Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.119-122

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001285085

pISSN: 1300-7416

Sayı

Yazarlar:

Salim İlksen Başçeken | Deniz Tikici

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Surgery

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.119-122

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001285085

pISSN:

1300-7416