Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism

Evrim ÇAKIR; Oya TOPALOĞLU; Nujen ÇOLAK BOZKURT; Başak KARBEK BAYRAKTAR

doi:https://doi.org/10.3906/sag-1303-80

Makale detayları

Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism

Yazarlar:

Evrim ÇAKIR | Oya TOPALOĞLU | Nujen ÇOLAK BOZKURT | Başak KARBEK BAYRAKTAR

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 5, pp.781-786

Belge Tipi:

Makale

Yayın Tarihi:

4/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753067

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1303-80

Anahtar kelimeler:

Özet:

 

Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH).   Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects.   Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and PCOS than controls, but these differences were not statistically significant. The participants who had a homeostasis model assessment insulin resistance index (HOMA-IR) greater than 2.7 had significantly higher IGF-1 and ALT levels. ALT levels were positively correlated with body mass index, FG, insulin and HOMA-IR.   Conclusion: The study illustrated that IGF-1 and ALT levels were significantly higher in patients with increased insulin resistance. Due to short disease duration in younger participants, we did not observe any correlation between IGF-1 and hyperinsulinemia. These findings suggest that increased hepatic production of IGF-I and ALT might be an early indicator of insulin resistance in hirsutism.

 

Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH).   Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects.   Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and PCOS than controls, but these differences were not statistically significant. The participants who had a homeostasis model assessment insulin resistance index (HOMA-IR) greater than 2.7 had significantly higher IGF-1 and ALT levels. ALT levels were positively correlated with body mass index, FG, insulin and HOMA-IR.   Conclusion: The study illustrated that IGF-1 and ALT levels were significantly higher in patients with increased insulin resistance. Due to short disease duration in younger participants, we did not observe any correlation between IGF-1 and hyperinsulinemia. These findings suggest that increased hepatic production of IGF-I and ALT might be an early indicator of insulin resistance in hirsutism.

Makale detayları

Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism

Yazarlar:

Evrim ÇAKIR | Oya TOPALOĞLU | Nujen ÇOLAK BOZKURT | Başak KARBEK BAYRAKTAR

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 5, pp.781-786

Belge Tipi:

Makale

Yayın Tarihi:

4/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753067

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1303-80

Cardiovascular disease risk

carotid intima media thickness

insulin-like growth factor 1

insulin resistance

polycystic ovary syndrome

Sayı

Makale detayları

Insulin-like growth factor 1, liver enzymes, and insulin resistance in patients with PCOS and hirsutism

Yazarlar: Evrim ÇAKIR | Oya TOPALOĞLU | Nujen ÇOLAK BOZKURT | Başak KARBEK BAYRAKTAR

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 5, pp.781-786

Belge Tipi: Makale

Yayın Tarihi: 4/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000753067

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1303-80

Cardiovascular disease risk

carotid intima media thickness

insulin-like growth factor 1

insulin resistance

polycystic ovary syndrome

Sayı

Yazarlar:

Evrim ÇAKIR | Oya TOPALOĞLU | Nujen ÇOLAK BOZKURT | Başak KARBEK BAYRAKTAR

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 5, pp.781-786

Belge Tipi:

Makale

Yayın Tarihi:

4/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000753067

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1303-80