Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils

Zarife Nigâr ÖZDEMİR-KUMRAL; Ahmet CUMHUR; Ali İhsan OLUK; Aykut HOŞCAN; İdris ÖNEM; Gazi CONTUK; Feriha ERCAN; Berrak YEĞEN

doi:https://doi.org/10.5152/clinexphealthsci.2017.606

Makale detayları

Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils

Yazarlar:

Zarife Nigâr ÖZDEMİR-KUMRAL | Ahmet CUMHUR | Ali İhsan OLUK | Aykut HOŞCAN | İdris ÖNEM | Gazi CONTUK | Feriha ERCAN | Berrak YEĞEN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 3, pp.175-181

Belge Tipi:

Makale

Yayın Tarihi:

9/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000907149

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.5152/clinexphealthsci.2017.606

Özet:

 


Purpose: Protective effects of nesfatin-1 was studied in sepsis-induced injury of

remote organs.

Methods: Male rats were randomly divided as control and sepsis (cecal ligationperforation)

groups, treated with either saline or nesfatin-1 (10 μg/kg). At 16 h

following surgery, samples of brain, kidney, liver and lung tissues were removed

and myeloperoxidase (MPO) activity, glutathione (GSH), catalase (CAT), superoxide

dismutase (SOD) and malondialdehyde (MDA) levels were measured in these

tissues.

Results: In saline-treated septic rats, elevated MDA and MPO activities were

accompanied with depleted CAT, SOD and GSH levels in the brain, kidney, liver

and lung tissues, implicating extensive oxidative damage in all remote organs.

Nesfatin-1 reduced MDA levels (brain, lung) and MPO activities (brain, kidney),

and preserved antioxidant GSH (brain, lung), CAT (brain) and SOD (kidney) levels.

Severe hepatocyte degeneration, neuronal damage, glomerulotubular degeneration

and alveolar disturbance in saline-treated septic rats were replaced with regular tissue

morphologies in nesfatin-1-treated rats.

Conclusion: Nesfatin-1 alleviates oxidative damage by enhancing endogenous

antioxidant systems and inhibiting recruitment of neutrophils, suggesting that

nesfatin-1 may be have a potential therapeutic impact on the treatment of septic

shock to reduce subsequent remote organ failure.

.

Makale detayları

Nesfatin-1 ameliorates sepsis-induced remote organ injury: The role of oxidant-antioxidant status and neutrophils

Yazarlar: Zarife Nigâr ÖZDEMİR-KUMRAL | Ahmet CUMHUR | Ali İhsan OLUK | Aykut HOŞCAN | İdris ÖNEM | Gazi CONTUK | Feriha ERCAN | Berrak YEĞEN

Yayıncı: Marmara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Clinical and Experimental Health Sciences 2018 Vol.8 Issue 3, pp.175-181

Belge Tipi: Makale

Yayın Tarihi: 9/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000907149

Sıklık: Aylık

eISSN: 2459-1459

DOI: https://doi.org/10.5152/clinexphealthsci.2017.606

Sayı

Yazarlar:

Zarife Nigâr ÖZDEMİR-KUMRAL | Ahmet CUMHUR | Ali İhsan OLUK | Aykut HOŞCAN | İdris ÖNEM | Gazi CONTUK | Feriha ERCAN | Berrak YEĞEN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 3, pp.175-181

Belge Tipi:

Makale

Yayın Tarihi:

9/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000907149

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.5152/clinexphealthsci.2017.606