THE EFFECTS OF HIGH SALT DIET AND EXERCISE ON THE WATER-SALT BALANCE AND BLOOD PRESSURE IN RATS

Buket GÜNGÖR; Afet Seçil AKDUR; Coşkun SILAN; Hakki Engin AKSULU; Orhan ŞAHİN

doi:https://doi.org/10.26900/jsp.5.1.05

Makale detayları

THE EFFECTS OF HIGH SALT DIET AND EXERCISE ON THE WATER-SALT BALANCE AND BLOOD PRESSURE IN RATS

Yazarlar:

Buket GÜNGÖR | Afet Seçil AKDUR | Coşkun SILAN | Hakki Engin AKSULU | Orhan ŞAHİN

Yayıncı:

Rating Academy

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Scientific Perspectives 2021 Vol.5 Issue 1, pp.55-69

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000743822

Sıklık:

Aylık

eISSN:

2791-6022

DOI:

https://doi.org/10.26900/jsp.5.1.05

Özet:

 

In  the  study  which  was  prepared  based  on  the  factors  that  can  take  place  in  essential  hypertension pathology;   We aimed to investigate the interactions of intensive exercise, high salt and partial  NOS  inhibition  applications  with  each  other,  the  effects on  water-salt  balance  and  blood pressure,  changes  in  the  intrarenal  dopaminergic  system,  which  is  an  important  natriuretic  system, and  the  participation  of  oxidative  stress.  The  rats  were  given  intensive  exercise  on  a  treadmill  at  a speed of 25 m / min at 5% inclination for 30 minutes a day, LNNA at a concentration of 50 mg / L and  56a  high  salt  diet  of  4%  for  7  days  either  separately  or  together.Blood  pressures  of  the  rats  were measured on the first and last days of the  experiment, and the  rats  were taken into metabolic cages; 24-hour  water  intake  and  urinevolume  were  measured.  Dopamine  levels  were  measured  in  24-hour urine to detect intrarenal dopamine synthesis. In addition, oxidative stress parameters in the serums of rats; TAS, TOS and OSI levels were measured. Blood pressure was found to be high in the groups in which  intensive  exercise  was  applied  together  with  LNNA  and  high  salt  diet.  While there  was  no change  in  the  water  balance  of  this  group,  it  was  found  that  sodium  excretion  and  dopamine  levels increased  in  24-hour  urine.  In  addition,  it  was  found  that  the  total  oxidant  status  increased  in  this group, and oxidative stress developed as a result of insufficient antioxidant system. It suggests that the reason  of  hypertension  that  develops  with  the  application  of  intensive  exercise  together  with  LNNA and  high  salt  diet  may  be  due  to  the  vascular  resistance  increasing  effect  of  oxidative  stress  rather than  water-salt  retention  and  it  points  out  the  necessity  of  studies  to  fully  detect  vascular  tissue oxidative stress markers and vascular oxidative damage.

Makale detayları

THE EFFECTS OF HIGH SALT DIET AND EXERCISE ON THE WATER-SALT BALANCE AND BLOOD PRESSURE IN RATS

Yazarlar: Buket GÜNGÖR | Afet Seçil AKDUR | Coşkun SILAN | Hakki Engin AKSULU | Orhan ŞAHİN

Yayıncı: Rating Academy

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Scientific Perspectives 2021 Vol.5 Issue 1, pp.55-69

Belge Tipi: Makale

Yayın Tarihi: 2/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000743822

Sıklık: Aylık

eISSN: 2791-6022

DOI: https://doi.org/10.26900/jsp.5.1.05

Sayı

Yazarlar:

Buket GÜNGÖR | Afet Seçil AKDUR | Coşkun SILAN | Hakki Engin AKSULU | Orhan ŞAHİN

Yayıncı:

Rating Academy

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Scientific Perspectives 2021 Vol.5 Issue 1, pp.55-69

Belge Tipi:

Makale

Yayın Tarihi:

2/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000743822

Sıklık:

Aylık

eISSN:

2791-6022

DOI:

https://doi.org/10.26900/jsp.5.1.05