Effect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patients

Burcu BARUTÇUOGLU; Zuhal PARILDAR; M. İşıl MUTAF; Dilek ÖZMEN; Emin ALİOĞLU; Sara HABİF; Oya BAYINDIR

Makale detayları

Effect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patients

Yazarlar:

Burcu BARUTÇUOGLU | Zuhal PARILDAR | M. İşıl MUTAF | Dilek ÖZMEN | Emin ALİOĞLU | Sara HABİF | Oya BAYINDIR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.239-248

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755143

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Hypertension and type 2 diabetes mellitus (DM) cause endothelial dysfunction and may result in cardiovascular disease. The aim of this study was to assess endothelial dysfunction in essential hypertensives, and normotensive and hypertensive type 2 diabetics and to evaluate the effect of telmisartan on endothelium in hypertensives.  Materials and methods: Eighteen essential hypertensives (group 1), 16 type 2 diabetic hypertensives (group 2), 10 type 2 diabetic normotensives (group 3), and 10 control subjects (group 4) were included in this study. Groups 1 and 2 received 40 mg/day telmisartan for 12 weeks and were evaluated at the beginning and end. Groups 3 and 4 were evaluated once by serum nitrate (NO), vascular cell adhesion molecule-1 (VCAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1), paraoxonase (PON1), urine microalbumin (MAU), and endothelium dependent flow mediated dilation (FMD).   Results: In groups 1, 2, and 3, PAI-1 (P < 0.001, for all) and MAU (P = 0.012, P = 0.006, P = 0.004, respectively) were significantly higher than they were in group 4. In group 2, PON1 was significantly lower than it was in groups 4 and 1 (P = 0.028, P < 0.001 respectively), and NO was significantly lower than it was in groups 1, 3, and 4 (P < 0.001, for all). Brachial artery FMD was significantly lower in groups 1 and 2 than it was in group 4 and FMD in group 2 was lower than it was in group 3. After telmisartan treatment there were significant increases in PON1 in groups 1 and 2, and in TM in group 2.   Conclusion: Type 2 DM and essential hypertension result in endothelial dysfunction. Telmisartan decreases blood pressure to normal ranges in hypertensives, but it has a minimal role in improvement of endothelial dysfunction.

 

Hypertension and type 2 diabetes mellitus (DM) cause endothelial dysfunction and may result in cardiovascular disease. The aim of this study was to assess endothelial dysfunction in essential hypertensives, and normotensive and hypertensive type 2 diabetics and to evaluate the effect of telmisartan on endothelium in hypertensives.  Materials and methods: Eighteen essential hypertensives (group 1), 16 type 2 diabetic hypertensives (group 2), 10 type 2 diabetic normotensives (group 3), and 10 control subjects (group 4) were included in this study. Groups 1 and 2 received 40 mg/day telmisartan for 12 weeks and were evaluated at the beginning and end. Groups 3 and 4 were evaluated once by serum nitrate (NO), vascular cell adhesion molecule-1 (VCAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1), paraoxonase (PON1), urine microalbumin (MAU), and endothelium dependent flow mediated dilation (FMD).   Results: In groups 1, 2, and 3, PAI-1 (P < 0.001, for all) and MAU (P = 0.012, P = 0.006, P = 0.004, respectively) were significantly higher than they were in group 4. In group 2, PON1 was significantly lower than it was in groups 4 and 1 (P = 0.028, P < 0.001 respectively), and NO was significantly lower than it was in groups 1, 3, and 4 (P < 0.001, for all). Brachial artery FMD was significantly lower in groups 1 and 2 than it was in group 4 and FMD in group 2 was lower than it was in group 3. After telmisartan treatment there were significant increases in PON1 in groups 1 and 2, and in TM in group 2.   Conclusion: Type 2 DM and essential hypertension result in endothelial dysfunction. Telmisartan decreases blood pressure to normal ranges in hypertensives, but it has a minimal role in improvement of endothelial dysfunction.

Makale detayları

Effect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patients

Yazarlar:

Burcu BARUTÇUOGLU | Zuhal PARILDAR | M. İşıl MUTAF | Dilek ÖZMEN | Emin ALİOĞLU | Sara HABİF | Oya BAYINDIR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.239-248

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755143

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Endothelial dysfunction

essential hypertension

type 2 diabetes mellitus

Sayı

Makale detayları

Effect of telmisartan on vascular endothelium in hypertensive and type 2 diabetic hypertensive patients

Yazarlar: Burcu BARUTÇUOGLU | Zuhal PARILDAR | M. İşıl MUTAF | Dilek ÖZMEN | Emin ALİOĞLU | Sara HABİF | Oya BAYINDIR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.239-248

Belge Tipi: Makale

Yayın Tarihi: 1/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000755143

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Endothelial dysfunction

essential hypertension

type 2 diabetes mellitus

Sayı

Yazarlar:

Burcu BARUTÇUOGLU | Zuhal PARILDAR | M. İşıl MUTAF | Dilek ÖZMEN | Emin ALİOĞLU | Sara HABİF | Oya BAYINDIR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.239-248

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755143

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144