Prognostic Insights into Congenital Solitary Functioning Kidneys among the Turkish Pediatric Population: A Comparative Study of Renal Agenesis and Multicystic Dysplastic Kidney Disease

Demet Tekcan Karalı; Hülya Nalçacıoğlu; Hülya Gözde Önal

Makale detayları

Prognostic Insights into Congenital Solitary Functioning Kidneys among the Turkish Pediatric Population: A Comparative Study of Renal Agenesis and Multicystic Dysplastic Kidney Disease

Yazarlar:

Demet Tekcan Karalı | Hülya Nalçacıoğlu | Hülya Gözde Önal

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 4, pp.356-363

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313419

pISSN:

1308-8491

Anahtar kelimeler:

Özet:

 Objective: Our study aims to assess the outcomes of solitary functioning kidneys SFKs resulting from unilateral renal agenesis URA and multicystic dysplastic kidney MCDK in order to identify the factors influencing kidney damage in these patients and to elucidate the potential contrasts between these two conditions. Methods: The study retrospectively analyzes 154 pediatric patients ages 0-18 with SFK treated at a tertiary center in Türkiye. Results: Among the 154 SFK patients, 91 are male, 74 were diagnosed with MCDK, and 80 with URA. The median age is one month at diagnosis and 69.5 months at the last follow-up. Most MCDK cases were identified antenatally, while URA was most commonly detected incidentally. Congenital anomalies of the kidney and urinary tract CAKUT in the functioning kidney were identified in 21.6 of MCDK patients and 7.5 of URA patients, with a significantly higher occurrence in MCDK patients p  0.012. Vesicoureteral Reflux VUR was the most prevalent CAKUT, occurring in 45 of patients. A low glomerular filtration rate GFR was observed in 12.4 of patients, and 15 exhibited signs of renal damage. No significant disparity was found in low GFR or kidney damage between MCDK and URA patients. Those with a low GFR showed increased rates of hydronephrosis, CAKUT in the functioning kidney, recurrent urinary tract infections UTIs, renal scarring, hypoplastic kidneys, proteinuria, and hypertension HT. Conclusions: The findings underline that CAKUT in the functioning kidney, recurrent UTIs, and renal scarring significantly influence GFR and kidney injury. VCUG is useful in select cases for identifying CAKUT, especially VUR. No significant distinction was observed between MCDK and URA concerning the eventual renal injury.

 Objective: Our study aims to assess the outcomes of solitary functioning kidneys SFKs resulting from unilateral renal agenesis URA and multicystic dysplastic kidney MCDK in order to identify the factors influencing kidney damage in these patients and to elucidate the potential contrasts between these two conditions. Methods: The study retrospectively analyzes 154 pediatric patients ages 0-18 with SFK treated at a tertiary center in Türkiye. Results: Among the 154 SFK patients, 91 are male, 74 were diagnosed with MCDK, and 80 with URA. The median age is one month at diagnosis and 69.5 months at the last follow-up. Most MCDK cases were identified antenatally, while URA was most commonly detected incidentally. Congenital anomalies of the kidney and urinary tract CAKUT in the functioning kidney were identified in 21.6 of MCDK patients and 7.5 of URA patients, with a significantly higher occurrence in MCDK patients p  0.012. Vesicoureteral Reflux VUR was the most prevalent CAKUT, occurring in 45 of patients. A low glomerular filtration rate GFR was observed in 12.4 of patients, and 15 exhibited signs of renal damage. No significant disparity was found in low GFR or kidney damage between MCDK and URA patients. Those with a low GFR showed increased rates of hydronephrosis, CAKUT in the functioning kidney, recurrent urinary tract infections UTIs, renal scarring, hypoplastic kidneys, proteinuria, and hypertension HT. Conclusions: The findings underline that CAKUT in the functioning kidney, recurrent UTIs, and renal scarring significantly influence GFR and kidney injury. VCUG is useful in select cases for identifying CAKUT, especially VUR. No significant distinction was observed between MCDK and URA concerning the eventual renal injury.

 Objective: Our study aims to assess the outcomes of solitary functioning kidneys SFKs resulting from unilateral renal agenesis URA and multicystic dysplastic kidney MCDK in order to identify the factors influencing kidney damage in these patients and to elucidate the potential contrasts between these two conditions. Methods: The study retrospectively analyzes 154 pediatric patients ages 0-18 with SFK treated at a tertiary center in Türkiye. Results: Among the 154 SFK patients, 91 are male, 74 were diagnosed with MCDK, and 80 with URA. The median age is one month at diagnosis and 69.5 months at the last follow-up. Most MCDK cases were identified antenatally, while URA was most commonly detected incidentally. Congenital anomalies of the kidney and urinary tract CAKUT in the functioning kidney were identified in 21.6 of MCDK patients and 7.5 of URA patients, with a significantly higher occurrence in MCDK patients p  0.012. Vesicoureteral Reflux VUR was the most prevalent CAKUT, occurring in 45 of patients. A low glomerular filtration rate GFR was observed in 12.4 of patients, and 15 exhibited signs of renal damage. No significant disparity was found in low GFR or kidney damage between MCDK and URA patients. Those with a low GFR showed increased rates of hydronephrosis, CAKUT in the functioning kidney, recurrent urinary tract infections UTIs, renal scarring, hypoplastic kidneys, proteinuria, and hypertension HT. Conclusions: The findings underline that CAKUT in the functioning kidney, recurrent UTIs, and renal scarring significantly influence GFR and kidney injury. VCUG is useful in select cases for identifying CAKUT, especially VUR. No significant distinction was observed between MCDK and URA concerning the eventual renal injury.

 Objective: Our study aims to assess the outcomes of solitary functioning kidneys SFKs resulting from unilateral renal agenesis URA and multicystic dysplastic kidney MCDK in order to identify the factors influencing kidney damage in these patients and to elucidate the potential contrasts between these two conditions. Methods: The study retrospectively analyzes 154 pediatric patients ages 0-18 with SFK treated at a tertiary center in Türkiye. Results: Among the 154 SFK patients, 91 are male, 74 were diagnosed with MCDK, and 80 with URA. The median age is one month at diagnosis and 69.5 months at the last follow-up. Most MCDK cases were identified antenatally, while URA was most commonly detected incidentally. Congenital anomalies of the kidney and urinary tract CAKUT in the functioning kidney were identified in 21.6 of MCDK patients and 7.5 of URA patients, with a significantly higher occurrence in MCDK patients p  0.012. Vesicoureteral Reflux VUR was the most prevalent CAKUT, occurring in 45 of patients. A low glomerular filtration rate GFR was observed in 12.4 of patients, and 15 exhibited signs of renal damage. No significant disparity was found in low GFR or kidney damage between MCDK and URA patients. Those with a low GFR showed increased rates of hydronephrosis, CAKUT in the functioning kidney, recurrent urinary tract infections UTIs, renal scarring, hypoplastic kidneys, proteinuria, and hypertension HT. Conclusions: The findings underline that CAKUT in the functioning kidney, recurrent UTIs, and renal scarring significantly influence GFR and kidney injury. VCUG is useful in select cases for identifying CAKUT, especially VUR. No significant distinction was observed between MCDK and URA concerning the eventual renal injury.

Makale detayları

Prognostic Insights into Congenital Solitary Functioning Kidneys among the Turkish Pediatric Population: A Comparative Study of Renal Agenesis and Multicystic Dysplastic Kidney Disease

Yazarlar:

Demet Tekcan Karalı | Hülya Nalçacıoğlu | Hülya Gözde Önal

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 4, pp.356-363

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313419

pISSN:

1308-8491

Solitary functioning kidney

unilateral renal agenesis

multicystic dysplastic kidney disease

chronic kidney disease

Sayı

Makale detayları

Prognostic Insights into Congenital Solitary Functioning Kidneys among the Turkish Pediatric Population: A Comparative Study of Renal Agenesis and Multicystic Dysplastic Kidney Disease

Yazarlar: Demet Tekcan Karalı | Hülya Nalçacıoğlu | Hülya Gözde Önal

Yayıncı: Istanbul University

Ana Başlıklar: Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi: Çocuk Dergisi Vol.23 Issue 4, pp.356-363

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001313419

pISSN: 1308-8491

Solitary functioning kidney

unilateral renal agenesis

multicystic dysplastic kidney disease

chronic kidney disease

Sayı

Yazarlar:

Demet Tekcan Karalı | Hülya Nalçacıoğlu | Hülya Gözde Önal

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 4, pp.356-363

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313419

pISSN:

1308-8491