Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats

Said Said ELSHAMA; Hosam-eldin Hussein OSMAN; Ayman El-meghawry EL-KENAWY; Hamdi Mohamed YOUSEEF

Makale detayları

Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats

Yazarlar:

Said Said ELSHAMA | Hosam-eldin Hussein OSMAN | Ayman El-meghawry EL-KENAWY | Hamdi Mohamed YOUSEEF

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 2, pp.524-538

Belge Tipi:

Makale

Yayın Tarihi:

3/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000752255

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Vitamin D3 has increased risk of toxicity due to its common use in multivitamin preparations. Vitamin K and vitamin A play an important role in vitamin D action. The goal of the current study was to compare the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 toxicity in rats by assessing serum calcium, renal function tests, cardiac enzymes, and related histopathological changes.  Materials and methods: Eighty adult albino rats were divided into four groups; each group consisted of 20 rats. The first group received water; the second received a toxic dose of vitamin D3; the third received a toxic dose of vitamin D3 with vitamin A; and the fourth received a toxic dose of vitamin D3 with vitamin K.   Results: Vitamin D3 toxicity led to significant abnormalities of cardiac enzymes, renal function tests, and serum calcium associated with histopathological changes in the kidney, heart, lung, adrenal gland, and aorta. Individual administration of vitamin A or vitamin K with a toxic dose of vitamin D improved the biochemical and histopathological abnormalities of hypervitaminosis D3.  Conclusion: Vitamins A and K showed the same protective effects in the modulation of hypervitaminosis D3 short-term toxicity.

Makale detayları

Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats

Yazarlar: Said Said ELSHAMA | Hosam-eldin Hussein OSMAN | Ayman El-meghawry EL-KENAWY | Hamdi Mohamed YOUSEEF

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 2, pp.524-538

Belge Tipi: Makale

Yayın Tarihi: 3/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000752255

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Said Said ELSHAMA | Hosam-eldin Hussein OSMAN | Ayman El-meghawry EL-KENAWY | Hamdi Mohamed YOUSEEF

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 2, pp.524-538

Belge Tipi:

Makale

Yayın Tarihi:

3/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000752255

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144