The relationship between lipid levels and clinical outcomes in sepsis patients in the intensive care unit: a retrospective study

Korhan Kollu; Muhammet Cemal Kızılarslanoğlu

Makale detayları

The relationship between lipid levels and clinical outcomes in sepsis patients in the intensive care unit: a retrospective study

Yazarlar:

Korhan Kollu | Muhammet Cemal Kızılarslanoğlu

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları | Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 6, pp.615-620

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330577

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: This study aimed to investigate the relationship between serum cholesterol levels HDL-C, LDL-C, and triglycerides and clinical outcomes in sepsis patients in an intensive care unit ICU. Methods: This retrospective study included patients aged 18 years diagnosed with sepsis who were admitted to the Internal Medicine ICUs of Konya City Hospital between June 15, 2021, and March 6, 2024. All data were obtained from routine blood tests of the patients in the ICU. Results: The study included 477 patients median age, 73 years; females, 45.9. The median levels of APACHE-II and SOFA scores were 27 range, 5-55 and 7 range, 2-19 points, respectively. The survived patients were younger and had lower median APACHE and SOFA scores compared to the non-survived patients p0.05 for all. The survived patients had higher levels of platelets, albumin, and HbA1c p0.001, p0.001, and p0.022, respectively, but significantly lower levels of HDL-C, triglycerides, and C-reactive protein CRP compared to the non-survived patients p0.026, p0.011, p0.034, respectively. In multivariable regression analyses to document independently related parameters, it was found that age HR: 1.030, SOFA score HR: 1.891, HDL-C HR: 1.054, and triglyceride HR: 1.007 levels were positively and independently related, while acute pancreatitis HR: 0.057 and albumin levels HR: 0.428 were inversely related to in-hospital mortality in the study population all had p-value 0.05. Conclusion: The findings highlight the potential utility of lipid biomarkers in risk assessment and prognostication in critically ill patients, emphasizing the need for further prospective research to elucidate underlying mechanisms and optimize therapeutic strategies for sepsis management in intensive care settings.

 Aims: This study aimed to investigate the relationship between serum cholesterol levels HDL-C, LDL-C, and triglycerides and clinical outcomes in sepsis patients in an intensive care unit ICU. Methods: This retrospective study included patients aged 18 years diagnosed with sepsis who were admitted to the Internal Medicine ICUs of Konya City Hospital between June 15, 2021, and March 6, 2024. All data were obtained from routine blood tests of the patients in the ICU. Results: The study included 477 patients median age, 73 years; females, 45.9. The median levels of APACHE-II and SOFA scores were 27 range, 5-55 and 7 range, 2-19 points, respectively. The survived patients were younger and had lower median APACHE and SOFA scores compared to the non-survived patients p0.05 for all. The survived patients had higher levels of platelets, albumin, and HbA1c p0.001, p0.001, and p0.022, respectively, but significantly lower levels of HDL-C, triglycerides, and C-reactive protein CRP compared to the non-survived patients p0.026, p0.011, p0.034, respectively. In multivariable regression analyses to document independently related parameters, it was found that age HR: 1.030, SOFA score HR: 1.891, HDL-C HR: 1.054, and triglyceride HR: 1.007 levels were positively and independently related, while acute pancreatitis HR: 0.057 and albumin levels HR: 0.428 were inversely related to in-hospital mortality in the study population all had p-value 0.05. Conclusion: The findings highlight the potential utility of lipid biomarkers in risk assessment and prognostication in critically ill patients, emphasizing the need for further prospective research to elucidate underlying mechanisms and optimize therapeutic strategies for sepsis management in intensive care settings.

 Aims: This study aimed to investigate the relationship between serum cholesterol levels HDL-C, LDL-C, and triglycerides and clinical outcomes in sepsis patients in an intensive care unit ICU. Methods: This retrospective study included patients aged 18 years diagnosed with sepsis who were admitted to the Internal Medicine ICUs of Konya City Hospital between June 15, 2021, and March 6, 2024. All data were obtained from routine blood tests of the patients in the ICU. Results: The study included 477 patients median age, 73 years; females, 45.9. The median levels of APACHE-II and SOFA scores were 27 range, 5-55 and 7 range, 2-19 points, respectively. The survived patients were younger and had lower median APACHE and SOFA scores compared to the non-survived patients p0.05 for all. The survived patients had higher levels of platelets, albumin, and HbA1c p0.001, p0.001, and p0.022, respectively, but significantly lower levels of HDL-C, triglycerides, and C-reactive protein CRP compared to the non-survived patients p0.026, p0.011, p0.034, respectively. In multivariable regression analyses to document independently related parameters, it was found that age HR: 1.030, SOFA score HR: 1.891, HDL-C HR: 1.054, and triglyceride HR: 1.007 levels were positively and independently related, while acute pancreatitis HR: 0.057 and albumin levels HR: 0.428 were inversely related to in-hospital mortality in the study population all had p-value 0.05. Conclusion: The findings highlight the potential utility of lipid biomarkers in risk assessment and prognostication in critically ill patients, emphasizing the need for further prospective research to elucidate underlying mechanisms and optimize therapeutic strategies for sepsis management in intensive care settings.

 Aims: This study aimed to investigate the relationship between serum cholesterol levels HDL-C, LDL-C, and triglycerides and clinical outcomes in sepsis patients in an intensive care unit ICU. Methods: This retrospective study included patients aged 18 years diagnosed with sepsis who were admitted to the Internal Medicine ICUs of Konya City Hospital between June 15, 2021, and March 6, 2024. All data were obtained from routine blood tests of the patients in the ICU. Results: The study included 477 patients median age, 73 years; females, 45.9. The median levels of APACHE-II and SOFA scores were 27 range, 5-55 and 7 range, 2-19 points, respectively. The survived patients were younger and had lower median APACHE and SOFA scores compared to the non-survived patients p0.05 for all. The survived patients had higher levels of platelets, albumin, and HbA1c p0.001, p0.001, and p0.022, respectively, but significantly lower levels of HDL-C, triglycerides, and C-reactive protein CRP compared to the non-survived patients p0.026, p0.011, p0.034, respectively. In multivariable regression analyses to document independently related parameters, it was found that age HR: 1.030, SOFA score HR: 1.891, HDL-C HR: 1.054, and triglyceride HR: 1.007 levels were positively and independently related, while acute pancreatitis HR: 0.057 and albumin levels HR: 0.428 were inversely related to in-hospital mortality in the study population all had p-value 0.05. Conclusion: The findings highlight the potential utility of lipid biomarkers in risk assessment and prognostication in critically ill patients, emphasizing the need for further prospective research to elucidate underlying mechanisms and optimize therapeutic strategies for sepsis management in intensive care settings.

Makale detayları

The relationship between lipid levels and clinical outcomes in sepsis patients in the intensive care unit: a retrospective study

Yazarlar:

Korhan Kollu | Muhammet Cemal Kızılarslanoğlu

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları | Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 6, pp.615-620

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330577

pISSN:

2636-8579

Sepsis

lipid levels

intensive care unit

lipid metabolism

prognosis

critically ill

Sayı

Makale detayları

The relationship between lipid levels and clinical outcomes in sepsis patients in the intensive care unit: a retrospective study

Yazarlar: Korhan Kollu | Muhammet Cemal Kızılarslanoğlu

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: İç Hastalıkları | Yoğun Bakım

Dergi: Journal of Health Sciences and Medicine Vol.7 Issue 6, pp.615-620

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330577

pISSN: 2636-8579

Sepsis

lipid levels

intensive care unit

lipid metabolism

prognosis

critically ill

Sayı

Yazarlar:

Korhan Kollu | Muhammet Cemal Kızılarslanoğlu

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

İç Hastalıkları | Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 6, pp.615-620

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330577

pISSN:

2636-8579