A genomic investigation on hybrid sterility in house mouse using a two stage model

Burak KARACAÖREN

doi:https://doi.org/10.1501/Vetfak_0000002872

Makale detayları

A genomic investigation on hybrid sterility in house mouse using a two stage model

Yazarlar:

Burak KARACAÖREN

Ana Başlıklar:

Hayvancılık

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi 2018 Vol.65 Issue 4, pp.387-393

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000849738

DOI:

https://doi.org/10.1501/Vetfak_0000002872

Özet:

 

Genome wide association studies (GWASs) commonly used to search for genetic variants associated withquantitative traits. Pleiotropic effect of genes may cause the observed correlations among different phenotypes. This study proposed atwo stage multilocus model for pleiotropic GWAS using a Bayesian mixture model to take into account of both small and major geneeffects. The objectives of this study were to investigate if the two-stage model was useful for detecting pleiotropic genes using asimulated data set and to investigate existence of pleiotropic genes for testis weight and testis gene expression levels in house mouse.The analyses included relative testis weight and testis gene expression traits. The results showed that two stage model had higher powerto detect the pleiotropic QTL than the single marker model. It was also noted the possible economical impact of sampling informativeindividuals for the GWAS analyses by observing genomic trends in the simulated dataset. Two stage model detected 50 and 53 majorSNP effects using first and the second principal components. Additive genetic variation explained by chromosome X was found to be4% for the testis weight.  .

Makale detayları

A genomic investigation on hybrid sterility in house mouse using a two stage model

Yazarlar: Burak KARACAÖREN

Ana Başlıklar: Hayvancılık

Dergi: Ankara Üniversitesi Veteriner Fakültesi Dergisi 2018 Vol.65 Issue 4, pp.387-393

Belge Tipi: Makale

Yayın Tarihi: 11/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000849738

DOI: https://doi.org/10.1501/Vetfak_0000002872

Sayı

Yazarlar:

Burak KARACAÖREN

Ana Başlıklar:

Hayvancılık

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi 2018 Vol.65 Issue 4, pp.387-393

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000849738

DOI:

https://doi.org/10.1501/Vetfak_0000002872