Comparative analysis of the potential effect of phase I therapy on gingival crevicular fluid myeloperoxidase levels in non-diabetic and diabetic patients with periodontitis

Hakan ÖZDEMİR; Hakan DEVELİOĞLU; Nermin YAMALIK; Hüseyin AYDIN; Kaya EREN

doi:https://doi.org/10.7126/cdj.58140.5000004490

Makale detayları

Comparative analysis of the potential effect of phase I therapy on gingival crevicular fluid myeloperoxidase levels in non-diabetic and diabetic patients with periodontitis

Yazarlar:

Hakan ÖZDEMİR | Hakan DEVELİOĞLU | Nermin YAMALIK | Hüseyin AYDIN | Kaya EREN

Dergi:

Cumhuriyet Dental Journal 2014 Vol.17 Issue 3, pp.256-266

Belge Tipi:

Makale

Yayın Tarihi:

1/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000735377

DOI:

https://doi.org/10.7126/cdj.58140.5000004490

Özet:

 


Objectives: To evaluate the effect of periodontal therapy on clinical parameters as well as on myeloperoxidase (MPO) activity in the gingival crevicular fluid (GCF) of patients with type 2 diabetes mellitus and of systemically healthy individuals.

Materials and Methods: 24 type 2 DM patients subjects, and 21 systemically healthy individuals, both groups with chronic periodontitis, and systemically and periodontally healthy individuals were enrolled. Periodontal clinical parameters, namely periodontal probing depth (PD), plaque index (PI), gingival index (GI), clinical attachment level (CAL), and gingival bleeding time index (GBI), as well as GCF MPO activity, were assessed before and 3 months after non-surgical periodontal therapy. GCF enzyme activity was spectrophotometrically analyzed. Possible correlation between clinical periodontal status and MPO activity was also evaluated.

Results: Despite the relatively stable clinical measures and GCF MPO content in the periodontally-healthy subjects, the clinical periodontal status improved, as significant reductions were observed in all of the clinical parameters in periodontitis patients with and without diabetes (p<0.05). GCF MPO activity presented with significant reductions in both of the periodontally-diseased groups after phase I treatment (p<0.05), however it could not reach to the level of periodontal health (p<0.05).

Conclusions: Periodontal inflammation is likely to play the major role in the higher MPO activity observed at diseased sites, while diabetes mellitus do not seem to further increase the production of this enzyme. Periodontal treatment can provide successful improvement in clinical periodontal parameters and reduction in enzyme profile of GCF in diabetics.

.

Makale detayları

Comparative analysis of the potential effect of phase I therapy on gingival crevicular fluid myeloperoxidase levels in non-diabetic and diabetic patients with periodontitis

Yazarlar: Hakan ÖZDEMİR | Hakan DEVELİOĞLU | Nermin YAMALIK | Hüseyin AYDIN | Kaya EREN

Dergi: Cumhuriyet Dental Journal 2014 Vol.17 Issue 3, pp.256-266

Belge Tipi: Makale

Yayın Tarihi: 1/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000735377

DOI: https://doi.org/10.7126/cdj.58140.5000004490

Sayı

Yazarlar:

Hakan ÖZDEMİR | Hakan DEVELİOĞLU | Nermin YAMALIK | Hüseyin AYDIN | Kaya EREN

Dergi:

Cumhuriyet Dental Journal 2014 Vol.17 Issue 3, pp.256-266

Belge Tipi:

Makale

Yayın Tarihi:

1/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000735377

DOI:

https://doi.org/10.7126/cdj.58140.5000004490