Comparison of diagnostic values of monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, red cell distribution width-lymphocyte ratio, and systemic inflammatory index in predicting patients with non-dipper hypertension

Serhat Günlü; Fethullah Kayan; Mehmet Zülkif Karahan

Makale detayları

Comparison of diagnostic values of monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, red cell distribution width-lymphocyte ratio, and systemic inflammatory index in predicting patients with non-dipper hypertension

Yazarlar:

Serhat Günlü | Fethullah Kayan | Mehmet Zülkif Karahan

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Cardiology

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 51, pp.27-33

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316372

pISSN:

2980-1915

Anahtar kelimeler:

Özet:

 Objective: Hypertension HTN is related to myocardial ischemia, malignant arrhythmias, and cardiovascular mortality. However, inflammatory biomarkers are an important predictor of cardiovascular events. This study aimed to examine the diagnostic utility of inflammatory biomarkers in determining non-dipper hypertensive individuals and the relative superiority of the biomarkers. Methods: The research was carried out as a retrospective observational study. Patients diagnosed with HTN were included in this study. Blood pressure BP measurements were obtained from Holter records. The patients were classified into two groups: non-dipper n54 and dipper n143 based on Holter monitoring. The cut-off value of MLR monocytelymphocyte ratio, NLR neutrophillymphocyte ratio, SII systemic inflammatory index, and RLR red cell distribution widthlymphocyte ratio for predicting non-dipper hypertension was determined using a receiver operating characteristic ROC analysis. Results: A total of 197 patients, comprising 84 females 42.6 and, 113 males 57.4 with a median age of 62 54-69 years, participated in the research. Age, FPG, CRP, WBC, NEU, LYM, MONO, RDW, NLR, MLR, RLR, and SII were higher in the non-dipper group p0.05. MLR, NLR, RLR, and SII were found to have acceptable diagnostic capabilities in identifying non-dipper hypertension patients AUC: 0.70-0.76. When ROC analysis was performed to determine the main similarities, it was found that there were no differences between inflammatory indicators p0.05. When the odds ratios of putative variables were evaluated, it was found that increasing MLR OR: 7.22; 95CI: 3.52-14.78; p0.001, NLR OR: 8.63; 95CI: 4.19-17.68; p0.001, RLR OR: 4.29; 95CI: 2.18-8.54; p0.001, and SII OR: 6.31; 95CI: 3.09-12.85; p0.001 were independent predictors for non-dipper positivity. Conclusion: In hypertensive patients, hematological inflammatory biomarkers MLR, NLR, RLR, and SII are valuable in determining non-dipper hypertension.

 Objective: Hypertension HTN is related to myocardial ischemia, malignant arrhythmias, and cardiovascular mortality. However, inflammatory biomarkers are an important predictor of cardiovascular events. This study aimed to examine the diagnostic utility of inflammatory biomarkers in determining non-dipper hypertensive individuals and the relative superiority of the biomarkers. Methods: The research was carried out as a retrospective observational study. Patients diagnosed with HTN were included in this study. Blood pressure BP measurements were obtained from Holter records. The patients were classified into two groups: non-dipper n54 and dipper n143 based on Holter monitoring. The cut-off value of MLR monocytelymphocyte ratio, NLR neutrophillymphocyte ratio, SII systemic inflammatory index, and RLR red cell distribution widthlymphocyte ratio for predicting non-dipper hypertension was determined using a receiver operating characteristic ROC analysis. Results: A total of 197 patients, comprising 84 females 42.6 and, 113 males 57.4 with a median age of 62 54-69 years, participated in the research. Age, FPG, CRP, WBC, NEU, LYM, MONO, RDW, NLR, MLR, RLR, and SII were higher in the non-dipper group p0.05. MLR, NLR, RLR, and SII were found to have acceptable diagnostic capabilities in identifying non-dipper hypertension patients AUC: 0.70-0.76. When ROC analysis was performed to determine the main similarities, it was found that there were no differences between inflammatory indicators p0.05. When the odds ratios of putative variables were evaluated, it was found that increasing MLR OR: 7.22; 95CI: 3.52-14.78; p0.001, NLR OR: 8.63; 95CI: 4.19-17.68; p0.001, RLR OR: 4.29; 95CI: 2.18-8.54; p0.001, and SII OR: 6.31; 95CI: 3.09-12.85; p0.001 were independent predictors for non-dipper positivity. Conclusion: In hypertensive patients, hematological inflammatory biomarkers MLR, NLR, RLR, and SII are valuable in determining non-dipper hypertension.

 Objective: Hypertension HTN is related to myocardial ischemia, malignant arrhythmias, and cardiovascular mortality. However, inflammatory biomarkers are an important predictor of cardiovascular events. This study aimed to examine the diagnostic utility of inflammatory biomarkers in determining non-dipper hypertensive individuals and the relative superiority of the biomarkers. Methods: The research was carried out as a retrospective observational study. Patients diagnosed with HTN were included in this study. Blood pressure BP measurements were obtained from Holter records. The patients were classified into two groups: non-dipper n54 and dipper n143 based on Holter monitoring. The cut-off value of MLR monocytelymphocyte ratio, NLR neutrophillymphocyte ratio, SII systemic inflammatory index, and RLR red cell distribution widthlymphocyte ratio for predicting non-dipper hypertension was determined using a receiver operating characteristic ROC analysis. Results: A total of 197 patients, comprising 84 females 42.6 and, 113 males 57.4 with a median age of 62 54-69 years, participated in the research. Age, FPG, CRP, WBC, NEU, LYM, MONO, RDW, NLR, MLR, RLR, and SII were higher in the non-dipper group p0.05. MLR, NLR, RLR, and SII were found to have acceptable diagnostic capabilities in identifying non-dipper hypertension patients AUC: 0.70-0.76. When ROC analysis was performed to determine the main similarities, it was found that there were no differences between inflammatory indicators p0.05. When the odds ratios of putative variables were evaluated, it was found that increasing MLR OR: 7.22; 95CI: 3.52-14.78; p0.001, NLR OR: 8.63; 95CI: 4.19-17.68; p0.001, RLR OR: 4.29; 95CI: 2.18-8.54; p0.001, and SII OR: 6.31; 95CI: 3.09-12.85; p0.001 were independent predictors for non-dipper positivity. Conclusion: In hypertensive patients, hematological inflammatory biomarkers MLR, NLR, RLR, and SII are valuable in determining non-dipper hypertension.

 Objective: Hypertension HTN is related to myocardial ischemia, malignant arrhythmias, and cardiovascular mortality. However, inflammatory biomarkers are an important predictor of cardiovascular events. This study aimed to examine the diagnostic utility of inflammatory biomarkers in determining non-dipper hypertensive individuals and the relative superiority of the biomarkers. Methods: The research was carried out as a retrospective observational study. Patients diagnosed with HTN were included in this study. Blood pressure BP measurements were obtained from Holter records. The patients were classified into two groups: non-dipper n54 and dipper n143 based on Holter monitoring. The cut-off value of MLR monocytelymphocyte ratio, NLR neutrophillymphocyte ratio, SII systemic inflammatory index, and RLR red cell distribution widthlymphocyte ratio for predicting non-dipper hypertension was determined using a receiver operating characteristic ROC analysis. Results: A total of 197 patients, comprising 84 females 42.6 and, 113 males 57.4 with a median age of 62 54-69 years, participated in the research. Age, FPG, CRP, WBC, NEU, LYM, MONO, RDW, NLR, MLR, RLR, and SII were higher in the non-dipper group p0.05. MLR, NLR, RLR, and SII were found to have acceptable diagnostic capabilities in identifying non-dipper hypertension patients AUC: 0.70-0.76. When ROC analysis was performed to determine the main similarities, it was found that there were no differences between inflammatory indicators p0.05. When the odds ratios of putative variables were evaluated, it was found that increasing MLR OR: 7.22; 95CI: 3.52-14.78; p0.001, NLR OR: 8.63; 95CI: 4.19-17.68; p0.001, RLR OR: 4.29; 95CI: 2.18-8.54; p0.001, and SII OR: 6.31; 95CI: 3.09-12.85; p0.001 were independent predictors for non-dipper positivity. Conclusion: In hypertensive patients, hematological inflammatory biomarkers MLR, NLR, RLR, and SII are valuable in determining non-dipper hypertension.

Makale detayları

Comparison of diagnostic values of monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, red cell distribution width-lymphocyte ratio, and systemic inflammatory index in predicting patients with non-dipper hypertension

Yazarlar:

Serhat Günlü | Fethullah Kayan | Mehmet Zülkif Karahan

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Cardiology

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 51, pp.27-33

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316372

pISSN:

2980-1915

Non-dipper hypertension

monocyte-lymphocyte

neutrophil-lymphocyte ratio

RDW-lymphocyte ratio

systemic inflammatory index

Sayı

Makale detayları

Comparison of diagnostic values of monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, red cell distribution width-lymphocyte ratio, and systemic inflammatory index in predicting patients with non-dipper hypertension

Yazarlar: Serhat Günlü | Fethullah Kayan | Mehmet Zülkif Karahan

Yayıncı: Hatay Mustafa Kemal University

Ana Başlıklar: Cardiology

Dergi: Interdisciplinary Medical Journal Vol.15 Issue 51, pp.27-33

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001316372

pISSN: 2980-1915

Non-dipper hypertension

monocyte-lymphocyte

neutrophil-lymphocyte ratio

RDW-lymphocyte ratio

systemic inflammatory index

Sayı

Yazarlar:

Serhat Günlü | Fethullah Kayan | Mehmet Zülkif Karahan

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Cardiology

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 51, pp.27-33

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316372

pISSN:

2980-1915