Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye

Tuğsen Büyükyıldırım; Fatma Sezer Şenol Deniz; Osman Tugay; Ayhan İbrahim Aysal; İlkay Erdoğan Orhan

Makale detayları

Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye

Yazarlar:

Tuğsen Büyükyıldırım | Fatma Sezer Şenol Deniz | Osman Tugay | Ayhan İbrahim Aysal | İlkay Erdoğan Orhan

Yayıncı:

Ankara University

Ana Başlıklar:

Medicinal and Aromatic Plants

Dergi:

Journal of Agricultural Sciences Vol.31 Issue 3, pp.835-845

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354933

pISSN:

1300-7580

Anahtar kelimeler:

Özet:

 Polygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effects, immunomodulatory activity, anti-aging potential, estrogenic activity and are used abroad as a source of resveratrol. For this purpose, biological activity studies, and phytochemical analysis were carried out in P. aviculare L., P. cognatum Meissn., P. patulum Bieb. subsp. patulum, and P. setosum Jacq. subsp. setosum growing in Turkish flora. Polygonum ethanol extracts were tested for their cholinesterase, elastase, collagenase, and tyrosinase enzyme inhibitory activities with spectrophotometry. P. aviculare root extract had the highest acetylcholinesterase inhibitory activity IC50 55.94  2.63 µgmL, while the best butrylcholinesterase inhibitory activity was observed for P. aviculare IC50 17.02  3.42 µgmL and P. patulum IC50 18.36  0.15. µgmL root extracts. All Polygonum root extracts showed moderate inhibitory activity against tyrosinase. In this study indicated that P. aviculare root IC50 169.33  3.58 µgmL had the highest anti-elastase activity. P. cognatum roots IC50 200.30  2.26 µgmL have potent inhibition against collagenase. LC-Q-ToF-MS analysis in Polygonum extracts indicated that resveratrol was not present in the extracts.

 Polygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effects, immunomodulatory activity, anti-aging potential, estrogenic activity and are used abroad as a source of resveratrol. For this purpose, biological activity studies, and phytochemical analysis were carried out in P. aviculare L., P. cognatum Meissn., P. patulum Bieb. subsp. patulum, and P. setosum Jacq. subsp. setosum growing in Turkish flora. Polygonum ethanol extracts were tested for their cholinesterase, elastase, collagenase, and tyrosinase enzyme inhibitory activities with spectrophotometry. P. aviculare root extract had the highest acetylcholinesterase inhibitory activity IC50 55.94  2.63 µgmL, while the best butrylcholinesterase inhibitory activity was observed for P. aviculare IC50 17.02  3.42 µgmL and P. patulum IC50 18.36  0.15. µgmL root extracts. All Polygonum root extracts showed moderate inhibitory activity against tyrosinase. In this study indicated that P. aviculare root IC50 169.33  3.58 µgmL had the highest anti-elastase activity. P. cognatum roots IC50 200.30  2.26 µgmL have potent inhibition against collagenase. LC-Q-ToF-MS analysis in Polygonum extracts indicated that resveratrol was not present in the extracts.

 Polygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effects, immunomodulatory activity, anti-aging potential, estrogenic activity and are used abroad as a source of resveratrol. For this purpose, biological activity studies, and phytochemical analysis were carried out in P. aviculare L., P. cognatum Meissn., P. patulum Bieb. subsp. patulum, and P. setosum Jacq. subsp. setosum growing in Turkish flora. Polygonum ethanol extracts were tested for their cholinesterase, elastase, collagenase, and tyrosinase enzyme inhibitory activities with spectrophotometry. P. aviculare root extract had the highest acetylcholinesterase inhibitory activity IC50 55.94  2.63 µgmL, while the best butrylcholinesterase inhibitory activity was observed for P. aviculare IC50 17.02  3.42 µgmL and P. patulum IC50 18.36  0.15. µgmL root extracts. All Polygonum root extracts showed moderate inhibitory activity against tyrosinase. In this study indicated that P. aviculare root IC50 169.33  3.58 µgmL had the highest anti-elastase activity. P. cognatum roots IC50 200.30  2.26 µgmL have potent inhibition against collagenase. LC-Q-ToF-MS analysis in Polygonum extracts indicated that resveratrol was not present in the extracts.

 Polygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effects, immunomodulatory activity, anti-aging potential, estrogenic activity and are used abroad as a source of resveratrol. For this purpose, biological activity studies, and phytochemical analysis were carried out in P. aviculare L., P. cognatum Meissn., P. patulum Bieb. subsp. patulum, and P. setosum Jacq. subsp. setosum growing in Turkish flora. Polygonum ethanol extracts were tested for their cholinesterase, elastase, collagenase, and tyrosinase enzyme inhibitory activities with spectrophotometry. P. aviculare root extract had the highest acetylcholinesterase inhibitory activity IC50 55.94  2.63 µgmL, while the best butrylcholinesterase inhibitory activity was observed for P. aviculare IC50 17.02  3.42 µgmL and P. patulum IC50 18.36  0.15. µgmL root extracts. All Polygonum root extracts showed moderate inhibitory activity against tyrosinase. In this study indicated that P. aviculare root IC50 169.33  3.58 µgmL had the highest anti-elastase activity. P. cognatum roots IC50 200.30  2.26 µgmL have potent inhibition against collagenase. LC-Q-ToF-MS analysis in Polygonum extracts indicated that resveratrol was not present in the extracts.

Makale detayları

Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye

Yazarlar:

Tuğsen Büyükyıldırım | Fatma Sezer Şenol Deniz | Osman Tugay | Ayhan İbrahim Aysal | İlkay Erdoğan Orhan

Yayıncı:

Ankara University

Ana Başlıklar:

Medicinal and Aromatic Plants

Dergi:

Journal of Agricultural Sciences Vol.31 Issue 3, pp.835-845

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354933

pISSN:

1300-7580

Polygonum

Enzyme inhibition

LC-Q-ToF-MS

Sayı

Makale detayları

Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye

Yazarlar: Tuğsen Büyükyıldırım | Fatma Sezer Şenol Deniz | Osman Tugay | Ayhan İbrahim Aysal | İlkay Erdoğan Orhan

Yayıncı: Ankara University

Ana Başlıklar: Medicinal and Aromatic Plants

Dergi: Journal of Agricultural Sciences Vol.31 Issue 3, pp.835-845

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001354933

pISSN: 1300-7580

Polygonum

Enzyme inhibition

LC-Q-ToF-MS

Sayı

Yazarlar:

Tuğsen Büyükyıldırım | Fatma Sezer Şenol Deniz | Osman Tugay | Ayhan İbrahim Aysal | İlkay Erdoğan Orhan

Yayıncı:

Ankara University

Ana Başlıklar:

Medicinal and Aromatic Plants

Dergi:

Journal of Agricultural Sciences Vol.31 Issue 3, pp.835-845

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354933

pISSN:

1300-7580