Assessing the Diagnostic Value of the Red Blood Cell Distribution-To- Platelet Ratio in Acute Leg Embolism Requiring Emergent Surgical Intervention

Ömer Faruk Çiçek; Ataberk Atalay; Adeviye Ünlü; Nisa Nur Babadağ; Şükran Aybike Ayyıldız

Makale detayları

Assessing the Diagnostic Value of the Red Blood Cell Distribution-To- Platelet Ratio in Acute Leg Embolism Requiring Emergent Surgical Intervention

Yazarlar:

Ömer Faruk Çiçek | Ataberk Atalay | Adeviye Ünlü | Nisa Nur Babadağ | Şükran Aybike Ayyıldız

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.608-613

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301352

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Background: The objective of this study was to evaluate the significance of the red blood cell distribution-to-platelet ratio RPR as a diagnostic indicator, derived from the initial hemogram measurements of patients who underwent emergent surgical treatment for acute leg embolism, by comparing it to a control group of healthy individuals. Methods: The study included 48 patients who underwent femoral embolectomy for acute lower limb ischemia, while an additional 49 individuals were enrolled as a control group. Demographic, clinical, and laboratory data were compared between the two groups. Using the receiver operating characteristic curve to determine the RPR cutoff value, the area under the curve, sensitivity, and specificity were calculated. Results: The age and gender distribution of both groups were comparable. The admission RPR values of patients who underwent surgery for acute embolism were statistically higher compared to healthy individuals 0.0677 IQR: 0.0547-0.0803 vs. 0.0504 IQR: 0.0441-0.0572, p0.001. The area under the curve for acute extremity embolism was determined to be 0.832, and the RPR cut-off value of 0.566 was found to predict acute extremity embolism with a sensitivity of 72.9 and a specificity of 73.5 p0.001. Conclusion: Our findings provide preliminary evidence that RPR can be used as a novel diagnostic indicator for acute leg embolism. Rather than being used diagnostically alone, it is thought that a comprehensive evaluation of this ratio, when combined with the patients medical history and other clinical findings, has the potential to expedite diagnostic process, particularly in healthcare settings with limited access to imaging resources.

 Background: The objective of this study was to evaluate the significance of the red blood cell distribution-to-platelet ratio RPR as a diagnostic indicator, derived from the initial hemogram measurements of patients who underwent emergent surgical treatment for acute leg embolism, by comparing it to a control group of healthy individuals. Methods: The study included 48 patients who underwent femoral embolectomy for acute lower limb ischemia, while an additional 49 individuals were enrolled as a control group. Demographic, clinical, and laboratory data were compared between the two groups. Using the receiver operating characteristic curve to determine the RPR cutoff value, the area under the curve, sensitivity, and specificity were calculated. Results: The age and gender distribution of both groups were comparable. The admission RPR values of patients who underwent surgery for acute embolism were statistically higher compared to healthy individuals 0.0677 IQR: 0.0547-0.0803 vs. 0.0504 IQR: 0.0441-0.0572, p0.001. The area under the curve for acute extremity embolism was determined to be 0.832, and the RPR cut-off value of 0.566 was found to predict acute extremity embolism with a sensitivity of 72.9 and a specificity of 73.5 p0.001. Conclusion: Our findings provide preliminary evidence that RPR can be used as a novel diagnostic indicator for acute leg embolism. Rather than being used diagnostically alone, it is thought that a comprehensive evaluation of this ratio, when combined with the patients medical history and other clinical findings, has the potential to expedite diagnostic process, particularly in healthcare settings with limited access to imaging resources.

 Background: The objective of this study was to evaluate the significance of the red blood cell distribution-to-platelet ratio RPR as a diagnostic indicator, derived from the initial hemogram measurements of patients who underwent emergent surgical treatment for acute leg embolism, by comparing it to a control group of healthy individuals. Methods: The study included 48 patients who underwent femoral embolectomy for acute lower limb ischemia, while an additional 49 individuals were enrolled as a control group. Demographic, clinical, and laboratory data were compared between the two groups. Using the receiver operating characteristic curve to determine the RPR cutoff value, the area under the curve, sensitivity, and specificity were calculated. Results: The age and gender distribution of both groups were comparable. The admission RPR values of patients who underwent surgery for acute embolism were statistically higher compared to healthy individuals 0.0677 IQR: 0.0547-0.0803 vs. 0.0504 IQR: 0.0441-0.0572, p0.001. The area under the curve for acute extremity embolism was determined to be 0.832, and the RPR cut-off value of 0.566 was found to predict acute extremity embolism with a sensitivity of 72.9 and a specificity of 73.5 p0.001. Conclusion: Our findings provide preliminary evidence that RPR can be used as a novel diagnostic indicator for acute leg embolism. Rather than being used diagnostically alone, it is thought that a comprehensive evaluation of this ratio, when combined with the patients medical history and other clinical findings, has the potential to expedite diagnostic process, particularly in healthcare settings with limited access to imaging resources.

 Amaç: Bu çalışmanın amacı, akut bacak embolisi nedeniyle acil cerrahi tedavi uygulanan hastaların başvuru hemogram ölçümlerinden elde edilen kırmızı kan hücresi dağılımı-trombosit oranının RPR tanısal bir gösterge olarak önemini, sağlıklı bireylerden oluşan bir kontrol grubuyla karşılaştırarak değerlendirmektir. Yöntemler: Çalışmaya akut alt ekstremite iskemisi nedeniyle femoral embolektomi yapılan 48 hasta dahil edilirken, 49 kişi de kontrol grubu olarak kaydedilmiştir. Demografik, klinik ve laboratuvar verileri iki grup arasında karşılaştırılmıştır. RPR kesme değerini belirlemek için receiver operating characteristic eğrisi kullanılarak eğri altında kalan alan, duyarlılık ve özgüllük hesaplanmıştır. Bulgular: Her iki grubun yaş ve cinsiyet dağılımı benzerdi. Akut emboli nedeniyle ameliyat edilen hastaların başvuru RPR değerleri sağlıklı bireylere kıyasla istatistiksel olarak daha yüksekti 0,0677 IQR: 0,0547-0,0803 vs. 0,0504 IQR: 0,0441-0,0572, p0,001. Akut ekstremite embolisi için eğri altında kalan alan 0,832 olarak belirlenmiş ve 0,566 RPR kesim değerinin akut ekstremite embolisini 72,9 duyarlılık ve 73,5 özgüllükle öngördüğü bulunmuştur p0,001. Sonuç: Bulgularımız, RPRnin akut bacak embolisi için yeni bir tanısal gösterge olarak kullanılabileceğine dair ön kanıtlar sunmaktadır. Bu oranın tek başına tanısal olarak kullanılmasından ziyade, hastanın tıbbi geçmişi ve diğer klinik bulgularla birleştirildiğinde kapsamlı bir değerlendirmesinin, özellikle görüntüleme kaynaklarına sınırlı erişimi olan sağlık hizmeti ortamlarında tanısal süreci hızlandırma potansiyeline sahip olduğu düşünülmektedir.

Makale detayları

Assessing the Diagnostic Value of the Red Blood Cell Distribution-To- Platelet Ratio in Acute Leg Embolism Requiring Emergent Surgical Intervention

Yazarlar:

Ömer Faruk Çiçek | Ataberk Atalay | Adeviye Ünlü | Nisa Nur Babadağ | Şükran Aybike Ayyıldız

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.608-613

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301352

pISSN:

2602-3741

acute leg ischemia

hemogram

platelet

red blood cell distributionakut bacak iskemisi

hemogram

kırmızı kan hücresi dağılımı

trombosit

Sayı

Makale detayları

Yazarlar: Ömer Faruk Çiçek | Ataberk Atalay | Adeviye Ünlü | Nisa Nur Babadağ | Şükran Aybike Ayyıldız

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Genel Tıp Dergisi Vol.33 Issue 5, pp.608-613

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001301352

pISSN: 2602-3741

Sayı

Yazarlar:

Ömer Faruk Çiçek | Ataberk Atalay | Adeviye Ünlü | Nisa Nur Babadağ | Şükran Aybike Ayyıldız

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.608-613

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301352

pISSN:

2602-3741