Relationship between ultrasonographic liver steatosis degree and oxidative/nitrosative stress in patients diagnosed with metabolic dysfunction-associated steatotic liver disease

Kamil Doğan; Ergül Belge Kurutaş; Velid Ünsal; Murat İspiroğlu; Mürvet Yüksel

Makale detayları

Relationship between ultrasonographic liver steatosis degree and oxidative/nitrosative stress in patients diagnosed with metabolic dysfunction-associated steatotic liver disease

Yazarlar:

Kamil Doğan | Ergül Belge Kurutaş | Velid Ünsal | Murat İspiroğlu | Mürvet Yüksel

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Metabolik Tıp

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 6, pp.391-396

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330722

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aims: Metabolic dysfunction-associated steatotic liver disease MASLD remains the most common chronic liver disease worldwide. It is considered to be a complication of metabolic syndrome. The main element in intra- and extrahepatic disorders in MASLD is oxidativenitrosative stress ONS. The relationship between the increase and decrease in these markers and the degree of liver steatosis defined sonographically has not been specifically studied before. Methods: Patients in the MASLD spectrum were divided into 3 groups according to the degree of liver steatosis on ultrasonography US. Patients without liver steatosis on US were taken as the control group. Nitric oxide NO, malondialdehyde MDA, catalase CAT and superoxide dismutase SOD were studied in the blood of these patients. Results: Changes in the degree of liver steatosis on US and changes in the studied parameters were found to be statistically significant. In addition, the cut-off values of NO and MDA were shown to be 8.98 and 2.375, respectively, in distinguishing the healthy control group from the patient group. Discussion: As the degree of liver steatosis increases on US, NO and MDA levels increase, while antioxidant enzymes CAT and SOD levels decrease. NO and MDA can be used to distinguish healthy and patient groups in the preliminary diagnosis of MASLD. Conclusion: There is a significant relationship between the degree of liver steatosis on US and ONS parameters.

 Aims: Metabolic dysfunction-associated steatotic liver disease MASLD remains the most common chronic liver disease worldwide. It is considered to be a complication of metabolic syndrome. The main element in intra- and extrahepatic disorders in MASLD is oxidativenitrosative stress ONS. The relationship between the increase and decrease in these markers and the degree of liver steatosis defined sonographically has not been specifically studied before. Methods: Patients in the MASLD spectrum were divided into 3 groups according to the degree of liver steatosis on ultrasonography US. Patients without liver steatosis on US were taken as the control group. Nitric oxide NO, malondialdehyde MDA, catalase CAT and superoxide dismutase SOD were studied in the blood of these patients. Results: Changes in the degree of liver steatosis on US and changes in the studied parameters were found to be statistically significant. In addition, the cut-off values of NO and MDA were shown to be 8.98 and 2.375, respectively, in distinguishing the healthy control group from the patient group. Discussion: As the degree of liver steatosis increases on US, NO and MDA levels increase, while antioxidant enzymes CAT and SOD levels decrease. NO and MDA can be used to distinguish healthy and patient groups in the preliminary diagnosis of MASLD. Conclusion: There is a significant relationship between the degree of liver steatosis on US and ONS parameters.

 Aims: Metabolic dysfunction-associated steatotic liver disease MASLD remains the most common chronic liver disease worldwide. It is considered to be a complication of metabolic syndrome. The main element in intra- and extrahepatic disorders in MASLD is oxidativenitrosative stress ONS. The relationship between the increase and decrease in these markers and the degree of liver steatosis defined sonographically has not been specifically studied before. Methods: Patients in the MASLD spectrum were divided into 3 groups according to the degree of liver steatosis on ultrasonography US. Patients without liver steatosis on US were taken as the control group. Nitric oxide NO, malondialdehyde MDA, catalase CAT and superoxide dismutase SOD were studied in the blood of these patients. Results: Changes in the degree of liver steatosis on US and changes in the studied parameters were found to be statistically significant. In addition, the cut-off values of NO and MDA were shown to be 8.98 and 2.375, respectively, in distinguishing the healthy control group from the patient group. Discussion: As the degree of liver steatosis increases on US, NO and MDA levels increase, while antioxidant enzymes CAT and SOD levels decrease. NO and MDA can be used to distinguish healthy and patient groups in the preliminary diagnosis of MASLD. Conclusion: There is a significant relationship between the degree of liver steatosis on US and ONS parameters.

 Giriş: Metabolik disfonksiyonla ilişkili steatotik karaciğer hastalığı MASLD, dünya çapında en sık görülen kronik karaciğer hastalığıdır. Metabolik sendromun bir komplikasyonu olarak kabul edilir. MASLDdeki intra- ve ekstrahepatik bozukluklardaki temel unsur, oksidatif türlerde artış ve antioksidan sistemlerde azalma ile oluşan oksidatif strestir. Bu belirteçlerdeki artış ve azalış ile sonografik olarak tanımlanan karaciğer steatozu derecesi arasındaki ilişki daha önce özel olarak incelenmemiştir. Materyal ve yöntem: MASLD spektrumundaki hastalar, USdeki karaciğer steatozu derecesine göre 3 gruba ayrıldı. USde karaciğer steatozu olmayan hastalar kontrol grubu olarak alındı. Bu hastaların kanında nitrik oksit NO, maledialdehit MDA, katalaz CAT ve süperoksit dismutaz SOD çalışıldı. Sonuçlar: USde karaciğer steatozu derecesindeki değişiklikler ve çalışılan parametrelerdeki değişiklikler istatistiksel olarak anlamlı bulundu. Ayrıca, NO ve maledialdehitin kesme değerlerinin sağlıklı kontrol grubunu hasta grubundan ayırmada sırasıyla 8,98 ve 2,375 olduğu gösterildi. Tartışma: USde karaciğer yağlanması derecesi arttıkça NO ve MDA düzeyleri artarken, antioksidan enzimler CAT ve SOD düzeyleri azalır. NO ve MDA, MASLDnin ön tanısında sağlıklı ve hasta gruplarını ayırt etmek için kullanılabilir. Sonuç: ABDde karaciğer yağlanması derecesi ile Oksidatifnitrozatif stres parametreleri arasında anlamlı bir ilişki vardır.

Makale detayları

Relationship between ultrasonographic liver steatosis degree and oxidative/nitrosative stress in patients diagnosed with metabolic dysfunction-associated steatotic liver disease

Yazarlar:

Kamil Doğan | Ergül Belge Kurutaş | Velid Ünsal | Murat İspiroğlu | Mürvet Yüksel

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Metabolik Tıp

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 6, pp.391-396

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330722

pISSN:

2718-0115

Oxidative/nitrosative stress

metabolic dysfunction-associated steatotic liver disease

ultrasonographyUltrasonografi

Oksidatif/nitrozatif stres

Metabolik disfonksiyonla ilişkili karaciğer yağlanması

Sayı

Makale detayları

Relationship between ultrasonographic liver steatosis degree and oxidative/nitrosative stress in patients diagnosed with metabolic dysfunction-associated steatotic liver disease

Yazarlar: Kamil Doğan | Ergül Belge Kurutaş | Velid Ünsal | Murat İspiroğlu | Mürvet Yüksel

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Radyoloji ve Organ Görüntüleme | Metabolik Tıp

Dergi: Anatolian Current Medical Journal Vol.6 Issue 6, pp.391-396

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330722

pISSN: 2718-0115

Oxidative/nitrosative stress

metabolic dysfunction-associated steatotic liver disease

ultrasonographyUltrasonografi

Oksidatif/nitrozatif stres

Metabolik disfonksiyonla ilişkili karaciğer yağlanması

Sayı

Yazarlar:

Kamil Doğan | Ergül Belge Kurutaş | Velid Ünsal | Murat İspiroğlu | Mürvet Yüksel

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Metabolik Tıp

Dergi:

Anatolian Current Medical Journal Vol.6 Issue 6, pp.391-396

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330722

pISSN:

2718-0115