Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma

Neslişah Barlak; Gülnur Kuşdemir; Rasim Gumus; Abdulkadir Şahin; Betül Gündoğdu; Ömer Faruk Karatas; Arzu Tatar

Makale detayları

Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma

Yazarlar:

Neslişah Barlak | Gülnur Kuşdemir | Rasim Gumus | Abdulkadir Şahin | Betül Gündoğdu | Ömer Faruk Karatas | Arzu Tatar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Biochemistry and Cell Biology (Other) | Otorhinolaryngology

Dergi:

The European Research Journal Vol.9 Issue 3, pp.517-528

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284929

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Laryngeal squamous cell carcinomas LSCC is one of the most common aggressive neoplasms of the head and neck region. There is a significant need for identification of successful and accurate prognostic markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the differential expressions of inhibitor growth  ING  family members and to evaluate the prognostic values of deregulated ING genes in LSCC. Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs in the mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the protein level using Western Blot analysis. Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancer including LSCC. ING3 expression was significantly upregulated in LSCC tissue samples in both mRNA and protein level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and neck cancer. Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.

 Objectives: Laryngeal squamous cell carcinomas LSCC is one of the most common aggressive neoplasms of the head and neck region. There is a significant need for identification of successful and accurate prognostic markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the differential expressions of inhibitor growth  ING  family members and to evaluate the prognostic values of deregulated ING genes in LSCC. Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs in the mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the protein level using Western Blot analysis. Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancer including LSCC. ING3 expression was significantly upregulated in LSCC tissue samples in both mRNA and protein level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and neck cancer. Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.

 Objectives: Laryngeal squamous cell carcinomas LSCC is one of the most common aggressive neoplasms of the head and neck region. There is a significant need for identification of successful and accurate prognostic markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the differential expressions of inhibitor growth  ING  family members and to evaluate the prognostic values of deregulated ING genes in LSCC. Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs in the mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the protein level using Western Blot analysis. Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancer including LSCC. ING3 expression was significantly upregulated in LSCC tissue samples in both mRNA and protein level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and neck cancer. Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.

 Objectives: Laryngeal squamous cell carcinomas LSCC is one of the most common aggressive neoplasms of the head and neck region. There is a significant need for identification of successful and accurate prognostic markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the differential expressions of inhibitor growth  ING  family members and to evaluate the prognostic values of deregulated ING genes in LSCC. Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs in the mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the protein level using Western Blot analysis. Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancer including LSCC. ING3 expression was significantly upregulated in LSCC tissue samples in both mRNA and protein level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and neck cancer. Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.

Makale detayları

Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma

Yazarlar:

Neslişah Barlak | Gülnur Kuşdemir | Rasim Gumus | Abdulkadir Şahin | Betül Gündoğdu | Ömer Faruk Karatas | Arzu Tatar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Biochemistry and Cell Biology (Other) | Otorhinolaryngology

Dergi:

The European Research Journal Vol.9 Issue 3, pp.517-528

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284929

pISSN:

2149-3189

Larynx cancer

ING gene family

oncogene

prognosis

Sayı

Makale detayları

Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma

Yazarlar: Neslişah Barlak | Gülnur Kuşdemir | Rasim Gumus | Abdulkadir Şahin | Betül Gündoğdu | Ömer Faruk Karatas | Arzu Tatar

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Biochemistry and Cell Biology (Other) | Otorhinolaryngology

Dergi: The European Research Journal Vol.9 Issue 3, pp.517-528

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001284929

pISSN: 2149-3189

Larynx cancer

ING gene family

oncogene

prognosis

Sayı

Yazarlar:

Neslişah Barlak | Gülnur Kuşdemir | Rasim Gumus | Abdulkadir Şahin | Betül Gündoğdu | Ömer Faruk Karatas | Arzu Tatar

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Biochemistry and Cell Biology (Other) | Otorhinolaryngology

Dergi:

The European Research Journal Vol.9 Issue 3, pp.517-528

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284929

pISSN:

2149-3189